Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients

Lamego, Murilo Khede; Moura, Antonio Marcos de Souza; Paes, Flávia; Rocha, Nuno; Filho, Alberto Souza de Sá; Lattari, Eduardo; Rimes, Ridson; Manochio, João; Budde, Henning; Wegner, Mirko; Mura, Gioia; Arias-Carrión, Óscar; Yuan, Ti‐Fei; Nardi, Antônio Egídio; Machado, Sérgio

doi:10.2174/1871527315666151111125402

Cited by 5 publications

(3 citation statements)

References 150 publications

(191 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship among BDNF, sleep and depression has been speculated. A low neurotrophic activity is associated with a reduced number of cells in the prefrontal cortex, amygdala, and decreased hippocampal size, indicating that BDNF may play an important role in the development of depression [ 12 ]. Some authors speculate that BDNF has a potential role in the pathology and treatment of numerous psychiatric disorders [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been speculating the relationship between BDNF, sleep and depression. There is evidence that BDNF levels influence sleep patterns in individuals with depression [ 12 ]. Some authors postulate that increasing BDNF levels may improve the sleep quality of depressed subjects, and in these cases the BDNF levels make a difference in the results found in treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review

Monteiro¹,

Monteiro²,

Candida³

et al. 2017

CPEMH

Self Cite

View full text Add to dashboard Cite

The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review

Monteiro¹,

Monteiro²,

Candida³

et al. 2017

CPEMH

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been speculating the relationship between BDNF, sleep and depression. There is evidence that BDNF levels influence sleep patterns in individuals with depression (Lamego et al, 2015).…”

Section: Sleep Quality and Bdnfmentioning

confidence: 99%

Brain-derived neurotrophic factor (BDNF) levels and subjective sleep quality in the first trimester of pregnancy among Myanmar migrant workers in Samut Sakhon province, Thailand: a secondary data analysis

Kriengtuntiwong¹

View full text Add to dashboard Cite

Background: During pregnancy, mother will face many challenges in this time because so many things will change to their health, mental health, family and social. Result from these change lead pregnant woman to have mental illness both antepartum and postpartum period. Depression and poor sleep quality are common mental health problem during pregnancy, and these symptoms have effect to mother and child health. Brain-derived neurotrophic factor (BDNF) is one of the biomarkers that association with depression and sleep quality during pregnancy. Migrant people are risk group that will have treatment gap from Thailand health system. Samut Sakhon is the province that have migrant 2nd highest in Thailand after Bangkok. The objective of this study was to examine association between depression and sleep quality to BDNF level among pregnant migrant group at 1st trimester in Samut Sakhon, Thailand. Methodology: This research was a cross-sectional study which used secondary data from birth cohort study conducting between June 2018 to August 2019 on Myanmar migrants in Samut Sakhon, Thailand. A total of 108 participants was recruit to this study from data of birth cohort study that have all data to analysis. The sociodemographic data and health behavior were assessed by self-report questionnaire. Depression was assessed by Patient Health Questionnaire 9 (PHQ-9) questionnaire. Sleep quality was assessed by Pittsburgh Sleep Quality index (PSQI) questionnaire. Plasma BDNF levels were measured by enzyme-linked immunosorbent assay. Binary logistic regression to evaluate association between BDNF to depression and sleep quality. Result: From 108 participants, 36 participants (33.3%) have mild to severe depression, 31 participants (28.7%) have poor sleep quality and median range of BDNF was 6.38 ng/ml which used to separate into high (> 6.38) and low (≤6.38) BDNF group. After adjusted for confounder, we found that depression and sleep quality was significant association with BDNF level. For depression, mild to severe depression group have higher BDNF level compared to no to minimal depression group (aOR 2.972, 95% CI 1.111,7.949, p-value 0.030). For sleep quality, poor sleep quality will have lower BDNF level compared to good sleep quality (aOR 0.359, 95% CI 0.132,0.972, p-value 0.044). Conclusion: Depression and Poor sleep quality in pregnancy is associated with BDNF level. These 2 mental health problems can affect to maternal and newborn health. Thailand hospital should have system to screening depression and sleep quality in pregnancy that come for antenatal care at out patient unit.

show abstract

Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder

Kerling¹,

Kück²,

Tegtbur³

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients

Cited by 5 publications

References 150 publications

Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review

Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review

Brain-derived neurotrophic factor (BDNF) levels and subjective sleep quality in the first trimester of pregnancy among Myanmar migrant workers in Samut Sakhon province, Thailand: a secondary data analysis

Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder

Contact Info

Product

Resources

About