Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder

Kerling, Arno; Kück, Momme; Tegtbur, Uwe; Grams, Lena; Weber-Spickschen, S; Hanke, Alexander; Stubbs, Brendon; Kahl, K.G.

doi:10.1016/j.jad.2017.03.034

Cited by 74 publications

(38 citation statements)

References 28 publications

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“…The BDNF level of patients with depression has been found to be significantly reduced in several studies [116, 117]. Additionally, a reduced BDNF receptor TrkB level in the brain has also been reported [118].…”

Section: Antidepressant Drugs For Treating Chronic Pain-induced Dementioning

confidence: 99%

The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain

et al. 2017

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Chronic pain, as a stress state, is one of the critical factors for determining depression, and their coexistence tends to further aggravate the severity of both disorders. Unfortunately, their association remains unclear, which creates a bottleneck problem for managing chronic pain-induced depression. In recent years, studies have found considerable overlaps between pain- and depression-induced neuroplasticity changes and neurobiological mechanism changes. Such overlaps are vital to facilitating the occurrence and development of chronic pain and chronic pain-induced depression. In this review, we summarized the role of neuroplasticity in the occurrence and development of the two disorders in question and explored individualized application strategies of analgesic drugs and antidepressants that have different pharmacological effects in the treatment of chronic pain-induced depression. Therefore, this review may provide new insights into the understanding of association between chronic pain and depression.

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Section: Antidepressant Drugs For Treating Chronic Pain-induced Dementioning

confidence: 99%

The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain

et al. 2017

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“…Contrarily, in another study the effect of exercise was larger in plasma samples than in serum samples [10]. Serum BDNF increased after longitudinal aerobic exercise [11,12] and showed an association with thyroid hormone concentrations during antidepressant treatment [13], while plasma BDNF did not [11,13]. Even opposite effects of interventions on BDNF concentrations in serum and plasma have been reported: surgical stress increased plasma BDNF but decreased serum BDNF [14].…”

Section: Introductionmentioning

confidence: 99%

Stability of BDNF in Human Samples Stored Up to 6 Months and Correlations of Serum and EDTA-Plasma Concentrations

Polyakova

Schlögl

Sacher

et al. 2017

IJMS

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Brain-derived neurotrophic factor (BDNF), an important neural growth factor, has gained growing interest in neuroscience, but many influencing physiological and analytical aspects still remain unclear. In this study we assessed the impact of storage time at room temperature, repeated freeze/thaw cycles, and storage at −80 °C up to 6 months on serum and ethylenediaminetetraacetic acid (EDTA)-plasma BDNF. Furthermore, we assessed correlations of serum and plasma BDNF concentrations in two independent sets of samples. Coefficients of variations (CVs) for serum BDNF concentrations were significantly lower than CVs of plasma concentrations (n = 245, p = 0.006). Mean serum and plasma concentrations at all analyzed time points remained within the acceptable change limit of the inter-assay precision as declared by the manufacturer. Serum and plasma BDNF concentrations correlated positively in both sets of samples and at all analyzed time points of the stability assessment (r = 0.455 to rs = 0.596; p < 0.004). In summary, when considering the acceptable change limit, BDNF was stable in serum and in EDTA-plasma up to 6 months. Due to a higher reliability, we suggest favoring serum over EDTA-plasma for future experiments assessing peripheral BDNF concentrations.

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“…Penelitian Firth et al, (2018) metode Systematic Reviews and Meta-Analyses (PRISMA) terhadap 6 penelitian yang berjumlah 390 lansia, setelah diberikan perlakuan aerobik selama 6 minggu lansia tidak mengalami peningkatan volume hippocampus (g = 0,146, 95% CI: -0,011 -0,303 ; p = 0,07). Penelitian Kerling et al (2017) metode Systematic Reviews and Meta-Analyses (PRISMA) standard terhadap 14 penelitan yang berjumlah 737 orang berusia 24-76 tahun yang diberikan olahraga aerobik dan non aerobik dengan frekuensi 2-5 kali seminggu selama 3 bulan -24 bulan. Hasil penelitian menunjukkan melalui pemeriksaan struktural Magnetic Resonance Imaging (MRI), olahraga aerobik meningkatkan volume hippocampus, meningkatkan konsentrasi BDNF serum dan mempertahankan kemampuan kognitif.…”

Section: Pembahasanunclassified

The Effect of Moringa oleifera (Lam) Leaf Extracts on Growth of Chicken Embryo Induced by Alkohol

Wardani

Suryono

2019

NLJ

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Physical activity in the elderly will improve cognitive function. Biomolecular changes to see an increase in elderly cognitive function are characterized by an increase in the expression of plasma protein Brain Derived Nerve Factor (BDNF). Efforts to improve cognitive function can be done in Indonesian Cardio Gymnastic Serie-I. In this study the aim was to analyze the influence of Indonesian Cardio Gymnastic Serie-I three times a week for 6 weeks to Plasma Protein Expression of BDNF in Elderly. This study used a pre-experiment with the design of one group pre and post test for 27 samples of healthy elderly aged >60 years and routinely conduct Indonesian Cardio Gymnastic Serie-I 3 times a week for 6 weeks. To determine BDNF levels taken from elderly plasma blood then measured using the Enzime Link Immunosorbent Assay method. To analyze the influence of Indonesian Cardio Gymnastic Serie-I to plasma protein expression of BDNF, a paired t-test was used so that the mean differences between before and after gymnastics were known. There were differences in the mean BDNF plasma protein expression before and after Indonesian Cardio Gymnastic Serie-I (2174.52 ± 700.79 VS 1981.17 pg/mL, p = 0.40; p >0.05) with the mean difference was 192.69 which means Indonesian Cardio Gymnastic Serie-I 3 times a week for 6 weeks had no influence to plasma protein expression of BDNF because the level has decreased by 91.14% after exercising. ABSTRAKAktivitas fisik yang aktif pada lansia akan meningkatkan fungsi kognitif. Perubahan biomolekuler untuk melihat peningkatan fungsi kognitif lansia ditandai dengan peningkatan ekspresi protein plasma Plasma Brain Derived Nerve Factor (BDNF). Upaya untuk meningkatkan fungsi kognitif dapat dilakukan senam jantung sehat seri-I. Dalam penelitian ini bertujuan untuk menganalisis pengaruh senam jantung sehat seri-I 3 kali seminggu selama 6 minggu terhadap ekspresi protein plasma BDNF lansia. Penelitian ini menggunakan pre-eksperimen dengan rancangan one group pre and post test terhadap 27 sampel lansia sehat yang berusia >60 tahun dan rutin melakukan senam jantung sehat seri-I 3 kali seminggu selama 6 minggu. Untuk mengetahui kadar BDNF diambil dari darah plasma

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Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder

Abstract: Exercise training given as adjunct to standard guideline based treatment appears to have additional effects on BDNF serum concentrations in people with MDD. Our results add further evidence to the beneficial effects of exercise in the treatment of MDD.

Cited by 74 publications

References 28 publications

The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain

The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain

Stability of BDNF in Human Samples Stored Up to 6 Months and Correlations of Serum and EDTA-Plasma Concentrations

The Effect of Moringa oleifera (Lam) Leaf Extracts on Growth of Chicken Embryo Induced by Alkohol

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