The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice

Lindenschmidt, Robert C.; Tryka, A. Francine; Goad, Mary E.P.; Witschi, Hanspeter

doi:10.1016/0300-483x(86)90116-2

Cited by 170 publications

(84 citation statements)

References 13 publications

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“…5,16,20,21) Although there are some synthetic antioxidant compounds, such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), which are commonly used in processed foods, it has been reported that these compounds may have side effects. [22][23][24][25][26][27][28] In addition, it has been suggested that there is an inverse relationship between dietary intake of antioxidant-rich foods and the incidence of a number of human diseases. 29,30) Therefore, research into the determination of natural antioxidant sources is important.…”

mentioning

confidence: 99%

Antioxidant Properties of Some Medicinal Plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae)

Mavi

Terzi

Ozgen

et al. 2004

Biological & Pharmaceutical Bulletin

110

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are various forms of activated oxygen and nitrogen, which include free radicals such as superoxide ions (O 2 · Ϫ ), hydroxyl (OH · ) and nitric oxide radicals (NO · ), as well as non-free-radical species such as hydrogen peroxide (H 2 O 2 ) and nitrous acid (HNO 2 ). [1][2][3] In living organisms ROS and RNS can form in different ways. Normal aerobic respiration, stimulated polymorphonuclear leukocytes and macrophages, and peroxisomes appear to be the main endogenous sources of most of the oxidants produced by cells. [4][5][6] Exogenous sources of free radicals include tobacco smoke, ionising radiation, organic solvents and pesticides.7-10) Free radicals can cause lipid peroxidation in foods that leads to their deterioration. 11)Oxidation does affect not only lipids. ROS and RNS may cause DNA damage that could lead to mutation. 12,13) In addition, ROS and RNS have been implicated in more than 100 diseases, including malaria, acquired immunodeficiency syndrome, heart disease, stroke, arteriosclerosis, diabetes and cancer.6,14-16) When produced in excess, ROS can cause tissue injury, whilst, tissue injury can itself cause ROS generation.12) Nevertheless, all aerobic organisms, including human beings, have antioxidant defenses that protect against oxidative damage and numerous damage removal and repair enzymes to remove or repair damaged molecules. 8,[17][18][19] However, the natural antioxidant mechanisms can be inefficient, hence dietary intake of antioxidant compounds becomes important. 5,16,20,21) Although there are some synthetic antioxidant compounds, such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), which are commonly used in processed foods, it has been reported that these compounds may have side effects. [22][23][24][25][26][27][28] In addition, it has been suggested that there is an inverse relationship between dietary intake of antioxidant-rich foods and the incidence of a number of human diseases. 29,30) Therefore, research into the determination of natural antioxidant sources is important.In this study, it is aimed to determine the antioxidant activity (AA) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (DPPH-RSA), reducing powers (RP) and amount of total phenolic compounds (APC) of the some medicinal plants which have been used especially in Eastern Turkey. (AEF 21172). Activity studies were performed on decoctions (5%) and/or methanolic extracts (5%) of used parts of plants in the treatment. Extraction solvents and parts of plants were chosen by taking consideration the usage form of plants by public. Methanol extract was evaporated and then lyophilized, water extract was directly lyophilized. In the AA and DPPH-RSA studies, different concentration ranges were studied and data of 50, 100, 250 and 500 mg/l concentrations were given in all figures. MATERIALS AND METHODS Collection of Plants, Identification and ExtractionDetermination of Antioxidant Properties The in vitro antioxidant activit...

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mentioning

confidence: 99%

Antioxidant Properties of Some Medicinal Plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae)

Mavi

Terzi

Ozgen

et al. 2004

Biological & Pharmaceutical Bulletin

110

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“…Hence, it has been suggested that there is an inverse relationship between dietary intake of antioxidants and the incidence of the diseases related to oxidative stress (Rice-Evans et al, 1997; Lu and Foo, 2000). Although synthetic antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG) are commonly used for food processing, their toxic properties and unwanted side effects limit their widespread use (Lindenschmidt et al, 1986;Kehrer and DiGiovanni, 1990). For this reason, there has been a particular interest in the potential health benefits of natural antioxidants in medicinal and aromatic plants.…”

Section: Introductionmentioning

confidence: 99%

Investigation Of Antioxidant Potentials Of Solvent Extracts From Different Anatomical Parts Of <i>Asphodeline Anatolica</i> E. Tuzlaci: An Endemic Plant To Turkey

Zengin

2014

Afr. J. Trad. Compl. Alt. Med.

157

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Background: The genus Asphodeline (Liliaceae) is represented in Turkey by 20 taxa, which are traditionally used for medicinal purposes in Anatolia. Materials and Methods:In this study, we tested the phytochemical content and antioxidant effect of different solvent extracts obtained from different anatomical parts of Asphodeline anatolica. The different extracts of each plant parts were tested for antioxidant activity using different chemical assays. The total antioxidant components were also calculated. Results: Generally, acetone extracts produced the seed and root exhibited significantly higher antioxidant activity with high antioxidant components. Total phenolic content of extracts were significantly correlated with antioxidant potentials (except for, metal chelating activity). Conclusion: On the basis of the results obtained, A. anatolica extracts should be regarded as a valuable source of natural antioxidants for food and therapeutic applications.Key words: Asphodeline, Antioxidant activity, Free radical scavenging, Phenolics, Solvent extracts, Turkey. IntroductionFree radicals, especially reactive oxygen species (ROS), are highly unstable molecules; react with various organic substrates such as lipids, proteins, carbohydrates and DNA. The excessive production of free radicals is called "oxidative stress" and can result in serious diseases including cancer, atherosclerosis, rheumatoid arthritis and neurodegenerative diseases (Arouma, 2010). Defense against oxidative stress is therefore very important in preventing the development of diseases mentioned. Antioxidants are vital substances which possess the ability to protect the body from the damage caused by these radicals (Silva et al., 2005). Hence, it has been suggested that there is an inverse relationship between dietary intake of antioxidants and the incidence of the diseases related to oxidative stress (Rice-Evans et al., 1997;Lu and Foo, 2000). Although synthetic antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG) are commonly used for food processing, their toxic properties and unwanted side effects limit their widespread use (Lindenschmidt et al., 1986;Kehrer and DiGiovanni, 1990). For this reason, there has been a particular interest in the potential health benefits of natural antioxidants in medicinal and aromatic plants. In fact, many functional phytochemicals such as phenolics, flavonoids and carotenoids possessed powerful antioxidant activities (Wang et al., 2013) The genus Asphodeline belongs to the Liliaceae family and is present in south-west of Asia, Middle-Eastern countries and Mediterranean region. The genus comprises of 14 species worldwide. In Turkey, this genus represented by 20 taxa and 11 of them are endemic to Turkey (Mathews and Tuzlaci, 1984;Tuzlaci, 1987). The high number of endemics shows that Turkey is one of the gene centre of this genus. The Asphodeline species are known as çiriş plants and are abundant especially in the mountains and steppes of inner Anatolia regio...

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“…Z uwagi jednak na nieufność konsumentów wobec wielu substancji dodatkowych obecnych w żywności, producenci coraz częściej zastępują je przeciwutleniaczami pochodzenia naturalnego [9,27]. Są one bardziej akceptowane, gdyż kojarzy się je z pozytywnym oddziaływa-niem na organizm człowieka [13].…”

Section: Wprowadzenieunclassified

Evaluation of Antimicrobial and Antioxidant Activity of Sage in Meat Product

Hać‐Szymańczuk¹,

Cegiełka²

2015

zntj

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t r e s z c z e n i e Celem pracy było określenie wpływu dodatku szałwii lekarskiej (Salvia officinalis L.) na jakość mikrobiologiczną oraz przebieg procesów utleniania lipidów w produkcie wytworzonym z mięsa wieprzowego, po 1, 5 i 10 dniach przechowywania w warunkach chłodniczych (4 -6 ºC). Szałwia jest rośliną przyprawową dodawaną m.in. do żywności z uwagi na właściwości przeciwutleniające i przeciwbakteryjne. Do produktów mięsnych dodawano szałwię w postaci suszonej przyprawy (0,5 %) i ekstraktów: wodnego (2,0 %) oraz 40-i 70-procentowego alkoholowego (2,0 %). Zakres badań mikrobiologicznych obejmował oznaczenie ogólnej liczby drobnoustrojów, drobnoustrojów psychrotrofowych, bakterii z rodziny Enterobacteriaceae oraz enterokoków. Ponadto oznaczono wskaźnik TBA.Stwierdzono, że najsłabszym działaniem przeciwdrobnoustrojowym charakteryzował się susz z szał-wii, ponieważ w produkcie z jego udziałem oznaczono większą liczbę drobnoustrojów psychrotrofowych, z rodziny Enterobacteriaceae oraz enterokoków w porównaniu z pozostałymi produktami. Ekstrakty z szałwii, zarówno wodne, jak i alkoholowe, skutecznie hamowały wzrost większości oznaczanych drobnoustrojów w porównaniu z produktem kontrolnym, co stwierdzono w czasie całego okresu przechowywania zapakowanych próżniowo produktów. Ponadto wykazano, że szałwia, niezależnie od rodzaju preparatu, może być stosowana w celu spowolnienia procesów oksydacji lipidów w produktach z rozdrobnionego mięsa wieprzowego. Świadczyły o tym wartości wskaźnika TBA, które po 10 dniach przechowywania produktów z dodatkiem szałwii były co najmniej trzykrotnie niższe niż w produkcie kontrolnym.

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The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice

Cited by 170 publications

References 13 publications

Antioxidant Properties of Some Medicinal Plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae)

Antioxidant Properties of Some Medicinal Plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae)

Investigation Of Antioxidant Potentials Of Solvent Extracts From Different Anatomical Parts Of <i>Asphodeline Anatolica</i> E. Tuzlaci: An Endemic Plant To Turkey

Evaluation of Antimicrobial and Antioxidant Activity of Sage in Meat Product

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