The Effects of Curcumin Nanoparticles Incorporated into Collagen-Alginate Scaffold on Wound Healing of Skin Tissue in Trauma Patients

Abstract

Wound healing is a biological process that is mainly crucial for the rehabilitation of injured tissue. The incorporation of curcumin (Cur) into a hydrogel system is used to treat skin wounds in different diseases due to its hydrophobic character. In this study, sodium alginate and collagen, which possess hydrophilic, low toxic, and biocompatible properties, were utilized. Collagen/alginate scaffolds were synthesized, and nanocurcumin was incorporated inside them; their interaction was evaluated by FTIR spectroscopy. Morphological studies investigated structures of the samples studied by FE-SEM. The release profile of curcumin was detected, and the cytotoxic test was determined on the L929 cell line using an MTT assay. Analysis of tissue wound healing was performed by H&E staining. Nanocurcumin was spherical, its average particle size was 45 nm, and the structure of COL/ALG scaffold was visible. The cell viability of samples was recorded in cells after 24 h incubation. Results of in vivo wound healing remarkably showed CUR-COL/ALG scaffold at about 90% (p < 0.001), which is better than that of COL/ALG, 80% (p < 0.001), and the control 73.4% (p < 0.01) groups at 14 days/ The results of the samples’ FTIR indicated that nanocurcumin was well-entrapped into the scaffold, which led to improving the wound-healing process. Our results revealed the potential of nanocurcumin incorporated in COL/ALG scaffolds for the wound healing of skin tissue in trauma patients.

2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform

“…To reveal the best model for the curcumin release process from the PHEMA/G/A/TiO 2 hybrid scaffolds, the sum of the squared residuals (SSRs) and Akaike Information Criterion (AIC) was calculated and analyzed using four release kinetic models ( Table 2 ). The model with the smallest AIC value best describes the curcumin release phenomenon from the hybrid scaffolds [ 69 , 70 , 71 , 72 , 73 ]. Obtained AIC values indicated that Peppas–Sahlin and Peppas–Sahlin when m = 0.5 models best describe the curcumin release mechanism from obtained hybrid scaffolds.…”

Superior in vivo Wound-Healing Activity of Mycosynthesized Silver Nanogel on Different Wound Models in Rat

“…It is reported that collagen plays a key role in wound healing, which promotes the healing activity (Mobaraki et al, 2021 ). In our study, gel with AgNPs having the concentrations of 0.5 and 1 mg g −1 was found to be effective for incision wound healing.…”

“…At present, a number of NPs have been used in wound healing, such as polylactic-co-glycolic acid (PLGA)-curcumin NPs (Mobaraki et al, 2021 ), mucoadhesive NPs with enoxaparin (Yan et al, 2020 ), calcium-based NPs (Subramaniam et al, 2021 ), magnetic NPs (Noh et al, 2019 ), titanium dioxide NPs (Nikpasand and Parvizi, 2019 ), and copper NPs (Alizadeh et al, 2019 ).…”

Antibacterial and wound healing applications of curcumin in micro and nano-scaffolds based on chitosan, cellulose, and collagen

“…However, hydrophobicity, low stability properties in physiological fluids as well as side effects including diarrhea, nausea, and reduction in cell proliferation, increased apoptosis, focal necrosis in the liver, as well as decreased body weight in a high dose of curcumin, can be major complications to achieve an efficient drug formulation (19,20). In addition to secondary metabolites of medicinal plants (21)(22)(23), natural polymers such as chitosan, cellulose, and collagen can increase the bioavailability and biodegradability of curcumin in micro and nanoformulations (24)(25)(26). Additionally, these polymers or their derivatives can contribute positively to the wound healing phase involving hemostasis, inflammation (inflammatory response, immune recruitment, and pathogen removal), proliferation, and maturation (Figure 2) (27,28).…”