The effects of chlorine gas on the lungs of rats without spontaneous pulmonary disease

Bell, Deirdre P.; Elmes, P. C.

doi:10.1002/path.1700890132

Cited by 23 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The granulomatous lesions in the lungs of some of the conventional rats were similar in appearance to those caused by the fungus Abscidia in the lungs of ordinary rats which had been exposed to chlorine gas (Bell & Elmes, 1965). In this study the granulomas contained giant cells but fungal mycelium was not present.…”

Section: Dlsease In CD and Conventionalsupporting

confidence: 62%

See 1 more Smart Citation

Disease in a Caesarian-Derived Albino Rat Colony and in a Conventional Colony

Bell

1968

Lab Anim

Self Cite

View full text Add to dashboard Cite

A small caesarian-derived colony of albino rats was established in 1960 and has been maintained apparently free of specific pathogens by a simple and inexpensive method. The prevalence of disease, parasite infestations and other abnormalities has been compared in the caesarian-derived colony with rats of the same strain kept under conventional conditions. The investigation has shown that rats of the caesarian-derived colony were free from chronic respiratory disease, lice, worms in the urinary bladder, tape-worms, bartonellosis, salmonellosis, labyrinthitis and various minor infections, all of which were prevalent in rats kept under conventional conditions. Animals of both colonies were subject to a low incidence of tumours, which were of various types in the caesarian-derived rats but mainly mammary carcinomas in the controls. A haemorrhagic hepatic disease occurred for a short time in both colonies. The most prevalent congenital abnormality was one associated with hydronephrosis, pyelonephritis and a haemorrhagic renal disease; both colonies had a similar prevalence of these lesions. Occasional cases of hydrocephalus, situs inversus, cleft lip and cleft palate, microphthalmia and absent organs were observed in both colonies. The study has indicated that there are considerable advantages in using caesarian-derived rats in preference to conventional stock in experimental work.

show abstract

Section: Dlsease In CD and Conventionalsupporting

confidence: 62%

“…The fixation and staining techniques reported earlier (Bell & Elmes, 1965) have been used for all of the lung tissue. Any other tissues which appeared abnormal were fixed in Carnoy's fluid.…”

Section: Post-mortem and Histological Methodsmentioning

confidence: 99%

Disease in a Caesarian-Derived Albino Rat Colony and in a Conventional Colony

Bell

1968

Lab Anim

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the proliferation of fibroblasts and deposition of collagen appear limited to subchronic cadmium studies utilizing rodents. The presence of spontaneous pulmonary disease in rats alters the expression of the lesion resulting from inhalation exposure to chlorine (Elmes and Bell, 1963;Bell and Elmes, 1965) and silica dust (Eden and von Seeback, 1976;Chiappino and Vigliani, 1982). Whether spontaneous pulmonary disease alters the pathology induced by inhaled cadmium awaits further experimentation.…”

Section: Discussionmentioning

confidence: 97%

Pulmonary changes resulting from subchronic exposure to cadmium chloride aerosol

Kutzman

Drew

Shiotsuka

et al. 1986

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

Fischer-344 rats were exposed to 0.0, 0.3, 1.0, or 2.0 mg Cd/m3 as CdCl2 aerosol for 6 h/d, 5 d/wk, for 62 exposure days. Exposure to 2.0 mg Cd/m3 resulted in rapid weight loss, and all of the animals died within the first 45 exposure days. As a group, female rats survived significantly longer than the males. Exposure to Cd resulted in dose-dependent increases in lung weight. The increased weight was the result of additional tissue mass rather than edema. Both connective-tissue components, elastin and collagen, were significantly increased in the 1.0-mg/m3 group when these components were expressed on the basis of dry weight. Dose-dependent changes at the terminal bronchioles consisted of hyperplasia and flattening of type II cells, inflammation, and the proliferation of fibroblasts. Exposure to Cd also resulted in the development of intralymphatic microgranulomas in the perivascular and peribronchiolar lymphoid tissues.

show abstract

“…In contrast, it has been shown in experiments using air pollution models that the extent of other kinds of lung damage from inhaled agents might be affected by the state of infection of the animal used (Bell and Elmes, 1965;Creasia, Nettesheim, and Hammons, 1973;Rylander and Bergstr6m, 1973).…”

Section: Discussionmentioning

confidence: 99%