2014
DOI: 10.1590/s1677-5538.ibju.2014.01.16
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The effects of carvedilol on ischemia-reperfusion injury in the rat testis

Abstract: ARTICLE INFO ______________________________________________________________ ______________________Objective: To analyze the oxidative damage and histopathological alterations caused by ischemia-reperfusion (I/R) injury and ameliorative effects of carvedilol (CVD) in the rat testis. Materials and Methods: Twenty-one male rats were randomized into 3 groups as follows: Group I (n = 7); control (sham) group, Group II (n = 7); I/R group, in which I/R injury was performed by torsing the left testis 720º clockwise fo… Show more

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Cited by 24 publications
(18 citation statements)
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“…Parlaktas et al[103] investigated the antioxidant effects of carvedilol against I/R injury, and found a decrease in MDA and protein carbonyl and an increase in the level of antioxidant enzymes SOD, and GPX, but not histopathological changes against the control group. They concluded, that carvedilol may have a potential therapeutic value and improve fertility in the clinical practice in patients with TT.…”
Section: Searchmentioning
confidence: 99%
“…Parlaktas et al[103] investigated the antioxidant effects of carvedilol against I/R injury, and found a decrease in MDA and protein carbonyl and an increase in the level of antioxidant enzymes SOD, and GPX, but not histopathological changes against the control group. They concluded, that carvedilol may have a potential therapeutic value and improve fertility in the clinical practice in patients with TT.…”
Section: Searchmentioning
confidence: 99%
“…TBARS levels were studied in the homogenate and for a further extraction procedure, the supernatant was extracted in ethanol/chloroform mixture (5/3 v/v). After a second centrifugation at 3500×g for 20min 15 .…”
Section: Preparation Of Kidney Tissue Homogenatesmentioning
confidence: 99%
“…After a second centrifugation at 3500×g for 20min, the clear upper layer was taken and used for superoxide dismutase (SOD) activity determination 15 .…”
Section: Preparation Of Testicular Tissue Homogenatesmentioning
confidence: 99%