The Effects of Capsaicin and Vitamine E on High Fat Diet Induced Obesity, Hyperlipidemia and Oxidative Stress in Different Organs of Mice

Abstract

Obesity has become a leading global health problem and risk factor for development of a multiple organ dysfunction. The present study was aimed to determine effects of capsaicin (CAP) and Vitamine E (Vit E) on oxidative stress in certain extrahepatic tissue (kidney, heart, lung, intestine, spleen and thymus) and blood lipid levels of high fat (HF) diet mice. Fifty swiss albino mice were segregated into two groups; one fed standard diet (NC) and the other fed high-fat diet (HF) for 12 weeks. After 12 weeks, the HF group was divided into four groups according to whether they received supplements for 4 weeks: the HF group was fed high fat diet only; the HFC group given CAP (5 mg/kg, intragasticially); HFE group given Vit E (100 mg/kg, intragasticially) and HFCE group given together CAP and Vit E along with high fat diet. We inferred significant decrease in enzymatic and nonenzymatic antioxidants along with increase in kidney and heart injury markers such as urea, creatine, creatine kinase-MB (CK-MB) lactate dehidrogenase (LDH) and hyperlipidemia in high fat diet fed mice. Capsaicin and Vit E ameliorate these toxicity which might be explained partially via diminishing the generation of free radicals and hyperlipidemia. CAP and Vit E given together has been more effective on decreasing weight, fat pad gain and inflammation than the groups these supplement given separately. On the other hand, combined supplementation of CAP and Vit E showed not better effect on oxidative stress, hyperlipidemia and organ demage markers as compared to treatment alone.

Supplementation of Vitamin E 400 Iu Decreases Malondialdehyde Level of Obese Women Staff at School of Medicine Udayana University

“…On the other hand, non-enzymatic oxidative stress parameters lipid peroxidation markers MDA and protein oxidation markers level increased in these tissues. Increased MDA levels by the effects of high-fat diet were normalized in all tissues except the kidney with vitamin E [11]. This is in accordance with our results that vitamin E can decrease MDA levels in obese woman staff.…”

Protective Effect of Capsaicin against Doxorubicin Induced Cardiotoxicity in Experimental Rats

“…The decline in levels of serum biomarker findings in CAP administered animals might be due to its free radical scavenging action that reduces leakage of enzymes into bloodstream and stabilizes membrane permeability. 20 In present study, the cardiomyopathy is caused due to generation of oxygen derived free radicals. They cause direct injury to cell membranes, which disrupts cardiac membranes.…”

Isolation, characterization and hypolipidemic activity of ferulic acid in high-fat-diet-induced hyperlipidemia in laboratory rats

“…GSH is a non-enzymatic biological antioxidant which plays a significant role in quenching of free radical species (such as hydrogen peroxide, superoxide and alkoxy radicals) act as a free radical scavenger (Kandhare et al, 2014[26]). There was a subsequent increase in lipid peroxidation (MDA) with increased production of free radicals which was evident from the reduction of antioxidant status of HFD control rats (Aydin, 2015[2]; Kandhare et al, 2015[21]). Elevated MDA levels along with decreased levels of GSH and SOD mirrors with the toxic effects of ROS produced by HFD, which is consistent with previously reported observations where HFD-administration caused a marked reduction in tissue antioxidant level (Aydin, 2015[2]).…”

“…There was a subsequent increase in lipid peroxidation (MDA) with increased production of free radicals which was evident from the reduction of antioxidant status of HFD control rats (Aydin, 2015[2]; Kandhare et al, 2015[21]). Elevated MDA levels along with decreased levels of GSH and SOD mirrors with the toxic effects of ROS produced by HFD, which is consistent with previously reported observations where HFD-administration caused a marked reduction in tissue antioxidant level (Aydin, 2015[2]). Whereas, administration of FA significantly inhibited HFD induced alter oxidative stress which may be due to its antioxidant potential.…”

“…It has been reported that elevated NO production played a vital role in the induction of various diseases including hyperlipidemia (Aydin, 2015[2]). Tissue injury occurred when NO reacts with superoxide and forms peroxynitrites, and it is necessary to inhibit this NO production to ameliorate tissue injury (Kandhare et al, 2013[23], 2012[24]).…”