The Effects of Artery-Ligating and Artery-Preserving Varicocelectomy on the Ipsilateral Testes in Rats

Testicular immunohistochemical and Ultrastructural changes associated with chronic cholestasis in rats: Effect of ursodeoxycholic acid

“…Oxidative stress, mediated by the toxic hydrophobic bile acids and lipid peroxidation degradative products, provokes a defensive proliferative response by the myoid cells to form a barrier to toxic substances [36]. Such thickening results in the impairment of the transportation of oxygen, metabolites and hormones to the germinal epithelium [37], and end in testicular dysfunction [38,39]. The thickening of the basement membrane was reported in other models of testicular injury [36,40,41].…”

Testosterone and Varicocele

“…Multiple groups have recapitulated a dilated pampiniform plexus with subsequent development of infertility and decreased steroidogenesis in various animal models. [52][53][54][55][56][57][58] These studies afford a control group that is often subjected to sham procedures, thereby providing a strong level of evidence. One of the first notable investigations that addressed androgen production in the setting of varicocele was conducted by Rajfer and colleagues.…”

“…In this regard, technique may prove meaningful based on the results of Zheng and colleagues. 56 The investigators of this study evaluated artery-preserving versus artery-ligating varicocelectomy in an animal model. Their results demonstrated substantially lower values of intratesticular testosterone when the testicular artery was not spared.…”

The impact of varicocele and varicocele repair on serum testosterone

“…Another translational study by Zheng et al [18] addresses the impact of varicocele repair on serum testosterone levels. In this animal model, 50 adolescent SpragueDawley rats were divided into four groups: experimental 228 Reproductive endocrinology…”