Testicular immunohistochemical and Ultrastructural changes associated with chronic cholestasis in rats: Effect of ursodeoxycholic acid

Mahmoud, Yomna I.

doi:10.1016/j.lfs.2015.05.027

Cited by 8 publications

(4 citation statements)

References 84 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microscopic examination of testes of VC rats showed epithelium of the seminiferous tubules was disorganised and germ cells were decreased. And the observations are in agreement with other investigation of human testes of VC and other models of testes (Mahmoud, 2015; Ozgur, Kaya, Doran, & Solmaz, 2003; Terquem & Dadoune, 1981). While LRHC increased the amount of germ cells and improved the structure of VC rats, which suggested LRHC contributes to the histological structure restoration of VC testis.…”

Section: Discussionsupporting

confidence: 92%

“…The thickening of lamina propria in testes of VC rats may affect transportation of oxygen, glucose, metabolites and hormones, and further result in testicular function failure. Such thickening of lamina propria was reported in other testicular injury (Mahmoud, 2015; Ozgur et al., 2003). Basal lamina is a kind of extracellular matrix (ECM) and mainly composed of laminin secreted by Sertoli cells and collagen type IV secreted by myofibroblasts and Sertoli cells.…”

Section: Discussionsupporting

confidence: 68%

See 1 more Smart Citation

Effects of liver‐regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C‐KIT pathway

Liu

Yin

et al. 2020

Andrologia

View full text Add to dashboard Cite

Varicocele is characterised by abnormal enlargement of the veins of the pampiniform plexus and is related to male infertility. Data showed that 21%-41% of men with primary infertility and 70%-81% of those with secondary infertility suffered VC (Alsaikhan, Alrabeeah, Delouya, & Zini, 2016; Dabaja, Wosnitzer, & Goldstein, 2013). It is well known that left-sided varicoceles are predominant in male, and rightsided only varicocele is exceedingly rare (Pastuszak & Wang, 2015). The opinions for the prevalence of left VC include differences in the anatomic configuration between the left and right internal spermatic vein, scrotal hyperthermia, extensive production of reactive oxygen species (ROS), testicular hypoxia and venous hypotension (Alsaikhan

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 68%

Effects of liver‐regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C‐KIT pathway

Liu

Yin

et al. 2020

Andrologia

View full text Add to dashboard Cite

show abstract

“…They reported that HEV itself does not damage the tissues or site; it is the immune system that results in these histopathological alternations in the infected tissues [41]. In chronic cholestatic liver dysfunction model induced by bile duct ligation in mice and chickens, testes showed many structural changes including tubular distortion and atrophy, associated with thick irregular boundaries, vacuolation, disorganized epithelium, and exfoliated cells [42,43]. These changes were reported to result from "the detergent-like effect of the toxic bile acids" which is known to enhance membranous lipid polarity and fluidity [44,45].…”

Section: Other Types Of Liver Fibrosismentioning

confidence: 99%

Effect of liver fibrotic changes on testicular histological structure: An updated review

Faddladdeen¹

2019

Ann Clin Anal Med

View full text Add to dashboard Cite

The liver plays a crucial role in maintaining adequate endocrine homeostasis including the endocrine function of the testis. Testicular atrophy and gonadal dysfunction have been clinically reported in advanced cirrhotic liver diseases. This study was conducted to review the effect of liver fibrotic changes induced by different agents on the structure of testis and the mechanisms underlying these effects. Chemical-induced liver fibrosis was found to have a negative impact on testicular structures. Carbon tetrachloride (CCl4) was frequently described to increase apoptosis of spermatogenic cells and reduced testicular transferrin expression through enhancing lipid peroxidation or direct toxic effect on the testis. Thioacetamide, another hepatotoxin, was reported to have harmful effects on sperm structure and function. Deltamethrin had hepatic changes that were associated with marked degeneration in rat seminiferous tubules. Cyclosporine A, an immunosuppressive drug, induced Sertoli and germ cell vacuolation besides inducing hepatic cytotoxicity. Testes of rats which chronically received alcohol, showed hypocellularity of the seminiferous tubules, degeneration of germinal epithelial and interstitial cells along with reduced sperm count and motility which was attributed to changes in the structure of the mitochondria. Portasystemic shunting and portal hypertension in rats were associated with reduced volume of germinal epithelium, reduced cell birth, reduced or complete loss of spermatogenic activity and marked increase in apoptosis. Virus-induced chronic active hepatitis was associated with sperm damage and reduced sperm quality parameters. Conclusion: Hepatic fibrotic changes induced by different injurious stimuli were found to have a harmful impact on testicular structure and function.

show abstract

“…The oxidative stress induced by cholestasis causes cell damages (Assimakopoulos et al., 2006) and has also been shown to play an essential role in the disruption of testicular tissue function and development of infertility (Asadi, Bahmani, Kheradmand, & Rafieian‐Kopaei, 2017). Histological studies have shown that cholestasis disrupts the proliferation of spermatogenic cells, leading to the deformation of seminal tubes and preventing the maturation of germ cells (Mahmoud, 2015). It has been shown that in liver disorders, the concentration of bile acid is increased and changes in the level of bile acid, which take place in cholestasis, can influence the fertility rate of individuals (Sèdes et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Investigation of cholestasis‐related changes in characteristics of spermatogonial stem cells in testis tissue of male Wistar rats

2020

View full text Add to dashboard Cite

Paternal metabolic status is an important factor in the health status of offspring. Cholestasis, as a metabolic disorder, significantly disrupts spermatogenesis. Spermatogonial stem cells (SSCs) are considered the dividing germ cells, which maintain spermatogenesis throughout the lifespan. Here, we investigated the in vivo and in vitro effect(s) of cholestasis on SSCs. Cholestasis was induced in rats by bile duct How to cite this article: Hasani Fard AH, Mohseni Kouchesfehani H, Jalali H. Investigation of cholestasis-related changes in characteristics of spermatogonial stem cells in testis tissue of male Wistar rats.

show abstract

Testicular immunohistochemical and Ultrastructural changes associated with chronic cholestasis in rats: Effect of ursodeoxycholic acid

Cited by 8 publications

References 84 publications

Effects of liver‐regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C‐KIT pathway

Effects of liver‐regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C‐KIT pathway

Effect of liver fibrotic changes on testicular histological structure: An updated review

Investigation of cholestasis‐related changes in characteristics of spermatogonial stem cells in testis tissue of male Wistar rats

Contact Info

Product

Resources

About