Testosterone and Varicocele

Hayden, Russell; Tanrikut, Cigdem

doi:10.1016/j.ucl.2016.01.009

Cited by 35 publications

(19 citation statements)

References 64 publications

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“…However, the mean improvements were 123 ng/dL (95% CI 114.61 to 131.35) in hypogonadal (T <300 ng/dL) men and 12.73 ng/dL (−25.81 to 51.28) among eugonadal men who underwent varicocelectomy. These findings are in agreement with literature suggesting that men with low or low-normal testosterone may derive the greatest increases in testosterone from varicocelectomy 52 .…”

Section: Discussionsupporting

confidence: 92%

Extended indications for varicocelectomy

Machen

Sandlow

2019

F1000Res

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Section: Discussionsupporting

confidence: 92%

Extended indications for varicocelectomy

Machen

Sandlow

2019

F1000Res

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“…The initial studies with antioxidants were performed in VCL‐induced animal models with a summary of major results presented in Table 1. Although the antioxidant ingredients, dosages, duration of treatment, and parameters measured differed significantly from one study to another, major improvements were observed including a favorable effect on spermatogenesis, sperm count, motility, morphology and integrity of sperm DNA, enzymatic and non‐enzymatic antioxidant status of testicular tissue, and gonadotropin and testosterone levels 24,25,31‐34 . Antioxidant supplementation has also been the subject of several studies in VCL patients 31,32,35‐37 .…”

Section: Reactive Oxygen and Nitrogen Species (Ros/nos) And Vclmentioning

confidence: 99%

“…Here too, despite the great heterogeneity between clinical studies, beneficial effects were notable. Various studies have attempted to estimate the oxidative stress associated with VCL in patients as well as in animal models at the testicular and/or seminal/spermatozoa level 24,25,31‐34 . Several key markers have been evaluated, including intrinsic antioxidant systems (concentrations and activities of primary enzymatic antioxidants such as Superoxide dismutase (SOD), Glutathione peroxidases (GPxs), Catalase (CAT), Glutathione reductase (GR), and glutathione S‐transferases (GSTs), as well as non‐enzymatic primary antioxidant content (Glutathione, Thiols, Polyamines, and others small molecules exhibiting such activity, ie, Vitamins and minerals) and also some by‐products of their activities (such as H 2 O 2 ).…”

Section: Reactive Oxygen and Nitrogen Species (Ros/nos) And Vclmentioning

confidence: 99%

“…Although the exact pathogenesis of VCL is not well understood, the associated macroscopic testicular changes are well established. Several impaired biological processes associated with VCL including oxidative stress, 12,13 nitrosative stress, 14‐17 inflammation, hypoxia, 18,19 testis heat‐shock stress response, apoptosis, 20‐23 testis endocrine status, 24,25 and epigenetic alterations have been investigated over the last decade 26,27 . This review attempts to summarize the key findings reported to date in VCL patients as well as in animal models of VCL.…”

Section: Introductionmentioning

confidence: 99%

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Varicocoele and oxidative stress: New perspectives from animal and human studies

et al. 2020

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Background Varicocoele (VCL), one of the main causes of male subfertility, negatively affects testicular function. Due to limited access to human testicular tissue, animal model studies have been used to evaluate molecular and, recently, epigenetic changes attributed to pathophysiology induced by VCL. Objectives This review aims to provide an update on the latest findings regarding the link between VCL‐induced biochemical stress and molecular changes in germ cells and spermatozoa. Endocrine and antioxidant status, testicular chaperone‐specific hemostasis failure, altered testicular ion balance, metabolic disorders, and altered carbon cycling during spermatogenesis are among the many features that will be presented. Discussion Literature review coupled with our own findings suggests that ionic imbalance, hypoxia, hyperthermia, and altered blood flow could lead to severe chronic oxidative and nitrosative stress in patients with VCL leading to defective spermatogenesis and impairment of the integrity of all sperm cell components and compartments down to the epigenetic information they carry. Conclusion Since oxidative stress is an important feature of the reproductive pathology of VCL, therapeutic strategies such as the administration of appropriate antioxidants could be undertaken as a complementary non‐invasive treatment line.

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“…In the literature, several clinical studies have reported effect of varicocele on serum testosterone, and most studies reported effect of varicocele repair on serum testosterone level in general infertile men with varicocele [10][11][12]. However, very limited clinical studies have focused on the effect of varicocele repair on serum testosterone in hypogonadal men with varicocele, and only a few studies have reported effect of varicocele repair on sexual functions in the same hypogonadal population [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effect of microsurgical varicocele repair on sexual functions and testosterone in hypogonadal infertile men with varicocele

2020

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Objective: To investigate effect of microsurgical varicocele repair on sexual functions and serum total testosterone level in infertile hypogonadal men with varicocele, and also to determine factors that might predict improvement in total testosterone level after surgery. Methods: The study included 202 infertile hypogonadal men (total testosterone level of <3.5 ng/mL) with varicocele who underwent microsurgical sub-inguinal varicocele repair. Results: Mean serum total testosterone level significantly increased from 2.55 ± 0.66 ng/mL to 3.72 ± 1.34 ng/mL after varicocelectomy (p ¼ .000), and 105 patients (52%) had serum total testosterone level of !3.5 ng/mL after the surgery. Mean international index of erectile functions (IIEF-EF) score significantly increased from 27.47 ± 2.96 to 28.61 ± 2.02, post-operatively (p ¼ .000). Of the patients who had pre-operative IIEF-EF score of 26, 65.5% had IIEF-EF score of !26 after varicocelectomy. Of the patients who had pre-operative decreased libido, 86.6% had postoperative increased libido. Only older patient age was the predictor for having total testosterone level of !3.5 ng/mL after the surgery (p ¼ .031). Conclusions: Data suggest that serum total testosterone level, IIEF-EF score and sexual libido significantly increase after varicocele surgery. As the age increases, total testosterone level increased after varicocele surgery. Therefore, varicocele repair could be offered to hypogonadal men with clinically varicocele.

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Testosterone and Varicocele

Cited by 35 publications

References 64 publications

Extended indications for varicocelectomy

Extended indications for varicocelectomy

Varicocoele and oxidative stress: New perspectives from animal and human studies

Effect of microsurgical varicocele repair on sexual functions and testosterone in hypogonadal infertile men with varicocele

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