The Effects of Aqueous and Ethanolic Extracts of Vitex doniana Leaf on Postprandial Blood Sugar Concentration in Wister Rats

Yakubu, Ojochenemi Ejeh; Nwodo, O. F. C.; Udeh, Sylvester Michael Chukwuka; Abdulrahman, Muntaka

doi:10.9734/ijbcrr/2016/12893

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…The increase of TBARS concentration in the liver can be a consequence of critical accumulation of AlCl 3 , thereby causing hepatic lipid peroxidation. This result is in agreement with previous studies [17,18] that reported significant increase in TBARS levels of AlCl 3 treated rats. However, treatment with the plant extracts show that the plant possesses the ability to ameliorate the negative effects caused by AlCl 3 -toxicity.…”

Section: Discussionsupporting

confidence: 83%

Spermatogenic and Haematological effects of Aqueous and Ethanolic Extracts of Hymenocardia acida Stem Bark on Aluminium-Induced Toxicity in Male Wistar Rats

Oe¹,

Nwodo²,

C³

et al. 2017

Insights in Biomed

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This study was designed to determine the spermatogenic and haematological effects of aqueous and ethanolic stem bark extracts of Hymenocardia acida on Aluminium chloride-induced toxicity in male wistar rats. Thirty male albino Wistar rats were used and toxicity was induced using 100 mg/kg body weight (bw) AlCl 3 . The rats were distributed into six groups of five rats each. The drug and extract administration lasted for seven days, thereafter the animals sacrificed. The results indicated that oral dose of 100 mg/kg bw extracts of H. acida did not show any significant (p>0.05) change in testosterone levels when compared with both normal and negative control. Ethanolic extract showed non-significant (p>0.05) increase on Luteinizing hormone (LH) when compared with both normal and negative control group. Administration of AlCl 3 caused a significant (p<0.05) decrease in Follicle Stimulating Hormone (FSH), while the plants extracts caused a non-significant increase when compared with the negative control. Thiobarbituric Acid Reactive Substance (TBARS) increased significantly (p<0.05) in negative control, but decreased significantly in groups treated with aqueous and ethanolic extract of H. acida when compared with the negative control. Induction of AlCl 3 -toxicity caused a non-significant (p>0.05) alterations of most of the haematological parameters evaluated, but administration of the plant extracts was able to mildly ameliorate these effects (especially on RBC and Hb). The result of this study shows AlCl 3 toxicity causes alterations of LH, FSH and TBARS, but aqueous and ethanolic stem bark extracts of H. acida may possibly ameliorate the alteration. Also, AlCl 3 -toxicity mildly influences the synthesis of certain haematological indices, but the extracts may modulate some of this interference.

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Section: Discussionsupporting

confidence: 83%

Spermatogenic and Haematological effects of Aqueous and Ethanolic Extracts of Hymenocardia acida Stem Bark on Aluminium-Induced Toxicity in Male Wistar Rats

Oe¹,

Nwodo²,

C³

et al. 2017

Insights in Biomed

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“…10 Fresh leaves of the plant are also used as a blood builder for boosting iron levels and to treat diarrhoea, anaemia and sexually transmitted diseases. 11 Previously, we reported on the antioxidant activity of Ficus burtt-davyi Hutch, the cytotoxicity of the bioactive compounds from F. burtt-davyi as well as the nutritional and the toxicological assessment of heavy metals in edible fruits of Ficus sur Forssk. [12][13][14] In this study, we report on the isolation and identification of the bioactive compounds from the fruits and leaves of F. sur.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of the bioactive compounds from the edible fruits and leaves of Ficus sur Forssk. (Moraceae)

et al. 2022

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Ficus sur Forssk. (Moraceae) is a medicinal plant species found in Africa and the leaves are used in traditional medicine as a blood builder to boost iron levels for the treatment of anaemia, skin disorders and sexually transmitted diseases. In this study, a phytochemical investigation was conducted on F. sur and the antioxidant properties of the isolates and extracts were evaluated. The major secondary metabolites that were isolated from the fruits and leaves were the triterpenoid (lupeol), sterol (β-sitosterol), phaeophytin (phaeophytin a) and flavonoid (epicatechin). The findings reveal significantly higher (p<0.05) antioxidant activity for the methanol extract of the fruits (IC50 9.06 μg/mL), which may be attributed to the higher phenolic content and presence of epicatechin. The results show the species to be rich in pharmacologically active compounds that are documented to exhibit haematinic effects, stimulate reconstruction and cell proliferation in skin, and inhibit the growth and proliferation of pathogenic agents of sexually transmitted infections. This study therefore validates the ethnomedicinal use of the plant, and its consumption could have a profound influence on nutrition and health, especially amongst indigenous people of Africa.

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Ethanol Extract of Senna occidentalis Leaves May Ameliorate Haematological Damages Induced by Diethylnitrosamine in Wistar Rats

Yakubu¹,

Nwaneri-Ch²,

Ibuzo³

et al. 2020

J. of Plant Sciences

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The Effects of Aqueous and Ethanolic Extracts of Vitex doniana Leaf on Postprandial Blood Sugar Concentration in Wister Rats

Cited by 4 publications

References 13 publications

Spermatogenic and Haematological effects of Aqueous and Ethanolic Extracts of Hymenocardia acida Stem Bark on Aluminium-Induced Toxicity in Male Wistar Rats

Spermatogenic and Haematological effects of Aqueous and Ethanolic Extracts of Hymenocardia acida Stem Bark on Aluminium-Induced Toxicity in Male Wistar Rats

Antioxidant activity of the bioactive compounds from the edible fruits and leaves of Ficus sur Forssk. (Moraceae)

Ethanol Extract of Senna occidentalis Leaves May Ameliorate Haematological Damages Induced by Diethylnitrosamine in Wistar Rats

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