The Effects of Antidepressants on Obstructed and Unobstructed Gait in Healthy Elderly People

Draganich, Louis F.; Zacny, James P.; Klafta, Jerome M.; Karrison, Theodore

doi:10.1093/gerona/56.1.m36

Cited by 37 publications

(22 citation statements)

References 22 publications

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“…[19][20][21][22][23][24]). Lamoureux et al [21] studied the relationship between lower limb muscle strength and the obstructed gait in older adults and found a significant correlation.…”

Section: Introductionmentioning

confidence: 99%

Comparisons of the lower limb kinematics between young and older adults when crossing obstacles of different heights

2006

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“…[19][20][21][22][23][24]). Lamoureux et al [21] studied the relationship between lower limb muscle strength and the obstructed gait in older adults and found a significant correlation.…”

Section: Introductionmentioning

confidence: 99%

Comparisons of the lower limb kinematics between young and older adults when crossing obstacles of different heights

2006

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“…Several studies have documented that there is a relation between falling and the number of drugs used (15,16). Drugs with central nervous system (CNS) side effects, such as benzodiazepines, antidepressants, neuroleptics, anticonvulsants (15,16) and opioids (17) are known to increase the risk of fractures and fall-related injuries. Frequently the CNS effects of opioids happen starting opioid therapy or during substantial dose escalation.…”

Section: Risks Of Opioids Treatmentmentioning

confidence: 99%

Implications of analgesics use in osteoporotic-related pain treatment: focus on opioids

Vellucci

Mattia

Celidonio

et al. 2016

ccmbm

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SummaryBone loss is asymptomatic and will progress without pain and other symptoms until the occurrence of a fracture. The occurrence of a breaking bone induce acute pain determined and supported by a mechanical, inflammatory and neuropathic component. Very often the acute component evolves in a chronic musculoskeletal component. Overall objectives of the analgesic therapy can be summarized in pain relief, improving sleep, improve mobility, reduce anxiety, emotional component and depression. Osteoporosis is predominantly a condition of the elderly, more likely to have coexisting cardiovascular disease and age-related decline in renal function, receiving treatment for one or more comorbid conditions, taking multiple medications. Analgesic treatment with NSAIDs has negative effects on skeletal health and healing of the injured skeleton and increase risk of adverse events especially in older patients. Despite all opioids therapy represents a mainstay in the treatment of patients with moderate to severe pain, it can induce an endocrinopathy, which may affect bone metabolism. The negative effects of opioids on hormonal axis are not the same for all molecule and the choice of drug can be crucial in the treatment of patients with chronic pain.

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“…Safe and consistent obstacle negotiation requires compensatory locomotor adaptation regulated by CNS (Chen et al, 1991(Chen et al, , 1997Patla et al 1996;Draganich et al, 2001;Chou et al, 2003;Hahn & Chou, 2003;McKenzie & Brown, 2004;Lwet al, 2006).…”

Section: Elderlymentioning

confidence: 99%

Locomotor Adjustments Made by Toddlers While Stepping Over Obstacles

Zhang¹,

Gordon²,

Robertson³

et al. 2007

Journal of Biomechanics

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The Effects of Antidepressants on Obstructed and Unobstructed Gait in Healthy Elderly People

Abstract: The results for amitriptyline suggest that the subjects slowed their obstacle crossing speeds as a result of reduced CNS integrative capacities. Neither paroxetine nor desipramine significantly affected gait, psychomotor function, or mood.

Cited by 37 publications

References 22 publications

Comparisons of the lower limb kinematics between young and older adults when crossing obstacles of different heights

Comparisons of the lower limb kinematics between young and older adults when crossing obstacles of different heights

Implications of analgesics use in osteoporotic-related pain treatment: focus on opioids

Locomotor Adjustments Made by Toddlers While Stepping Over Obstacles

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