The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers

Abstract

Acute doses of DZP significantly impaired the harsh-braking performance as compared to acute doses of TSP. These findings suggest that TSP may be used more safely in patients' driving activities.

Early effect of NEURAPAS®balance on current source density (CSD) of human EEG

“…But, due to the combination of three plant-derived extracts the effects cannot be attributed to one of them. However, it is important to note, that at least no interference with cognitive performance could be seen as reported repeatedly during the use of other synthetic preparations like benzodiazepines as anti-anxiety drugs or serotonin-reuptake inhibitors for treatment of depression [1]. With respect to the rationale of combining the three extracts a more potent neuroactivity of the triple combination compared to Hypericum alone and the additive effects of Passiflora and Valeriana suggested a synergy between constituents of these herbal extracts as derived from in vitro experiments with multielectrode neurochips [22].…”

“…Under theses circumstances patients need help. Broad use of synthetic drugs like benzodiazepines or serotonin reuptake inhibitors is for example accompanied by serious side effects like cognitive impairment in the case of benzodiazepines [1] or heart and circulation problems in the case of reuptake inhibitors [2]. An alternative solution can be provided by administration of natural remedies.…”

Effects of ketamine on psychomotor, sensory and cognitive functions relevant for driving ability

“…Trailmaking B, a task commonly used to evaluate executive functions in various clinical situations, is a well-studied predictor of unsafe driving [139][140][141] and participant performance is significantly altered by ketamine administration. Moreover, the Wisconsin Card Sorting Test, [143][144][145].…”

Лечение Тревожно-Депрессивных Расстройств В Соматической Практике: Назначение Комбинации Экстрактов Зверобоя И Валерианы

“…Для лечения краткосрочных тревожных расстройств применяются бета-блокаторы и бензодиазепины, тогда как для терапии хронических состояний -селективные ингибиторы обратного захвата серотонина (СИОЗС), селективные ингибиторы обратного захвата серотонина и норадреналина (СИОЗСН) и ингибиторы моноамин-оксидазы (МАО). Однако эти препараты часто имеют выраженные побочные эффекты в виде изменений когнитивной сферы (в случае применения бензодиазе-пинов [1]) или проблем с сердечно-сосудистой системой (в случае применения ингибиторов обратного захвата серотонина [2]). Кроме того, нельзя не учитывать от-ношение пациентов к назначаемым препаратам, т.к.…”