The effects of ACTH- and vasopressin-analogues on CO2-induced retrograde amnesia in rats

Rigter, Henk; Riezen, H. van; Wied, D. de

doi:10.1016/0031-9384(74)90092-4

Cited by 218 publications

(28 citation statements)

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“…Since the memory impairments induced by physical (cerebral ischemia, brain injury) or chemical (drugs, anoxic treatment) means in the mouse one-trial passive avoidance test are improved by the administration of various drugs including cholinergic drugs such as physostigmine and oxotremorine before the retention trial (28,(35)(36)(37)(38), these memory impairments are considered to be due to disturbance of the retrieval process of memory rather than of the consolidation of memory (39). In a similar experiment in mice using a light-dark box, the shortened latency in the retention trial 24 hours after exposure to CO-, gas immediately following the acquisition trial was dose-dependently prolonged by oral administration of TA-0910 60 min before the retention trial.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog. (IV). Effects on experimental memory impairment in mice and rats.

Yamamura¹,

Kawakami²,

Nakagawa³

et al. 1991

Jpn.J.Pharmacol

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ABSTRACT-The effects of a new TRH analog, TA-0910, orally administered, on experimental memory impairments for the one-trial passive avoidance response in anoxic mice (light-dark box), active avoidance response in basal forebrain (BF)-lesioned rats (shuttle box), and delayed alternation task in scopolamine-treated rats (T-maze) were studied. In mice, TA-0910 (3 -30 mg) administered 60 min before the retention trial dose-dependently prolonged the passive avoidance response latency reduced by C02-exposure that was given immediately after the acquisition trial, but not when it was given 60 min before the acquisition or just after the anoxic treatment. In rats, TA-0910 (0.3-3 mg/kg) administered 40-60 min before the test trial, dose-dependently prevented the reduction in mean avoidance rate caused by BF-lesioning and elevated the scopolamine (0.1 mg/kg, i.p.)-induced reduction in percent correct choice level in the alternation task. TRH (30 -300 mg/kg), on the other hand, produced no improvements in any of the above tests. These results suggest that TA-0910 improves impaired memory by correcting the retrieval process of memory.Thyrotropin-releasing hormone (TRH) is a hypothalamic hormone that stimulates secretion of thyrotropin and prolactin. However, radioimmunoassay has demonstrated that twothirds of the total TRH content of the brain is distributed widely in areas other than the hypothalamus (1). Also, autoradiographic studies have revealed that TRH receptors of the brain are concentrated in the cerebral cortex and the limbic system (2, 3). Based on these findings, TRH is considered to play an important role in the brain in the maintenance of consciousness and emotional or intellectual functions (4). Moreover, Yarbrough and Pomara (5) recommended the use of TRH for the treatment of dementia of the Alzheimer type (DAT) from the functional relationship between TRH and central cholinergic nervous system and the effectiveness of TRH in the treatment of dementia of patients with amyotrophic lateral sclerosis complicated by degeneration of cholinergic nerves, and by Metcalf (6) and Griffiths (7) from the effect of TRH to improve disturbance of consciousness (8) and its antidepressant effect (9, 10).Recently, improvements in mental symptoms (such as disturbances in impressibility, emotional disturbances, reduced ability to think, deduced spontaneity, inertia, and apathy) were reported in patients with Alzheimer's disease (AD) and cerebrovascular dementia after administration of TRH (11,12). Tem-

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Section: Discussionmentioning

confidence: 99%

Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog. (IV). Effects on experimental memory impairment in mice and rats.

Yamamura¹,

Kawakami²,

Nakagawa³

et al. 1991

Jpn.J.Pharmacol

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“…This may result in a deficit in preserving the acquired responses of both active and passive avoidance behavior. DG-LVP was found to reduce CO2-induced amnesia for a passive avoidance response when administered prior to the single acquisition trial [ 14]. This also suggests that vasopressin analogues are involved in memory consolidation.…”

Section: Discussionmentioning

confidence: 76%

“…However, the possibility that these peptides influence retrieval cannot be excluded. DG-LVP had an anti-amnesic effect as well when injected prior to the retention trial [ 14]. Furthermore, vasopressin release is increased during the retention test of a passive avoidance response and the rate of increase is related to the avoidance latency of the rat [15].…”

Section: Discussionmentioning

confidence: 93%

Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain)

Bohus

Greidanus

Wied

1975

Physiology & Behavior

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165

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BOHUS, B., Tj. B. VAN WIMERSMA GREIDANUS AND D. DE WIED. Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain). PHYSIOL. BEHAV. 14(5) [609][610][611][612][613][614][615] 1975. -Behavioral and endocrine profiles were established of homozygous (HO-DI) and heterozygous (HE-DI) rats with hereditary hypothalamic diabetes insipidus in comparison to Wistar strain rats. HO-DI rats were inferior m acquiring and maintaining active and passive avoidance behavior. Behavioral deficits were most obwous in a step-through one-trial learning passive avoidance test and least in multiple trial one way active avoidance test. Plasma eortieosterone levels determined after the retention test appeared to be closely related to the passive avoidance behavior of the HO-DI rats. Passive avoidance immediately after the single learning trial was associated with elevated plasma corticosterone level; absence of avoidance and absence in plasma cortieosterone elevation was observed 24 hr after learning. These observations are compatible with the hypothesis that vasopressin is involved in the consolidation and/or retrieval of learned responses. Differences between HO-DI and Wistar rats m open field behavior, in response threshold to electric footshock, and in a number of somatic endocrine parameters are reported and discussed. Hereditary hypothalamlc diabetes msipidusVasopressln Shuttle box avoidance Pole jumping avoidance Step-through passive avoidance Plasma corticosterone response Open field Footshock responsiveness Body growth Hypophysis Adrenal Testis VASOPRESSIN or antidiuretic hormone (ADH) of posterior pituitary origin plays an important role in the organization of adaptive behavior. Removal of the posterior lobe of the pituitary gland interferes with the maintenance of a shuttle box avoidance response in the rat which can be restored by treatment with pitressin or lysine-8-vasopressin (LVP) [21]. Impaired acquisition of a similar avoidance response which occurs after hypophysectomy is ameliorated by LVP [ 6]. In the intact rat the same preparations increase resistance to extinction of both a shuttle box and pole jumping avoidance response [23,24,29] and facilitate passive avoidance behavior [2,5]. These behavioral effects of vasopressin are of a long term nature and last much longer than can be accounted for by the actual presence of the peptide in the organism [6,23,24]. The effect of vasopressin on behavior is not due to its classical endocrine activities. Desglycinamide-8-1yslne vasopressin (DG-LVP), a peptide isolated from hog pituitary material which lacks almost all antidiuretic and pressor activities [26], also stimulates avoidance acquisition in hypophysectomized rats [8], increases resistance to extinction of a pole jumping avoidance response [26], and improves passive avoidance retention in the intact rat [15]. These 609 observations together with those showing similar behavioral effects of intracerebrally and peripherally administered LVP [29] led to the hypothesis th...

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“…AVP affects memory processes by facilitating both storage and retrieval of information (Ader and De Wied, 1972;Rigter, Van Riezen, and De Wied, 1974;De Wied, 1976), whereas OXT generally has an opposite effect. This latter neuropeptide may be a naturally occurring amnesic neuropeptide (Bohus, Kovacs, and De Wied, 1978a).…”

mentioning

confidence: 99%

Neurohypophyseal peptide levels in CSF and plasma during passive avoidance behavior in rats

Mens

Egmond

Rotte

et al. 1982

Hormones and Behavior

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Levels of vasopressin (AVP), oxytocin (OXT), and neurophysin (NP) in CSF and plasma of rats were determined during acquisition and retention of passive avoidance behavior. None of the levels of neurohypophyseal peptides in CSF were changed either during the adaptation period, or during acquisition or the retention of this behavior. Moreover, no differences were found in hormone levels in CSF of the various groups of rats subjected to different shock intensities during the acquisition trial. The marked differences in individual latencies of nonavoiding rats, and the differences in latencies due to a different shock intensity applied during the learning trial were not reflected by changes in CSF hormone levels. Neither AVP nor NP levels in plasma were affected by the different shock intensities applied, when measured at 20 min after the learning trial. In contrast, a decrease in plasma OXT levels was observed after application of a shock intensity of 0.25 mA during the learning trial. During retention of the passive avoidance response plasma levels of AVP, OXT and NP were not different from the levels found in the nonshocked groups. It is suggested that under the conditions used in this study the CSF is apparently not involved in the distribution of neurohypophyseal peptides to their possible sites of behavioral action in the brain.Arginine-Svasopressin (AVP) and oxytocin (OXT) both modulate memory processes. AVP affects memory processes by facilitating both storage and retrieval of information (Ader and De Wied, 1972;Rigter, Van Riezen, and De Wied, 1974;De Wied, 1976), whereas OXT generally has an opposite effect. This latter neuropeptide may be a naturally occurring amnesic neuropeptide (Bohus, Kovacs, and De Wied, 1978a). Prom the effects of AVP in rats bearing lesions in various limbic structures as well as from the effects of locally applied vasopressin, it was suggested that AVP may act on intact midbrain limbic circuits, including

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The effects of ACTH- and vasopressin-analogues on CO2-induced retrograde amnesia in rats

Cited by 218 publications

References 20 publications

Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog. (IV). Effects on experimental memory impairment in mice and rats.

Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog. (IV). Effects on experimental memory impairment in mice and rats.

Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain)

Neurohypophyseal peptide levels in CSF and plasma during passive avoidance behavior in rats

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