Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain)

Bohus, B; Greidanus, T.B. van Wimersma; Wied, D. de

doi:10.1016/0031-9384(75)90189-4

Cited by 165 publications

(10 citation statements)

References 29 publications

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“…Administration of AVP induces a dose-dependent long lasting inhibition of extinction of active avoidance behavior and an improvement of passive avoidance behavior (Van Wimersma Greidanus and De Wied, 1977). Concerning endogenous AVP it has been shown that Brattleboro rats, homozygous for diabetes insipidus, which lack AVP completely, show disturbances in avoidance behavior (De Wied, Bohus, and Van Wimersma Greidanus, 1975;Bohus, Van Wimersma Greidanus, and De Wied, 1976;Bailey and Weiss, 1979) and similar phenomena are observed in Wistar rats treated intracere-broventricularly (i.c.v.) with AVP-antibodies in order to neutralize bioavailable AVP in the brain (Van Wimersma Greidanus, Dogterom, and De Wied, 1975;De Wied, 1975a, Bohus, Urban, Van Wimersma Greidanus, and.…”

Section: Introductionmentioning

confidence: 69%

Vasopressin levels in peripheral blood and in cerebrospinal fluid during passive and active avoidance behavior in rats

Greidanus¹,

Croiset²,

Goedemans³

et al. 1979

Hormones and Behavior

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Vasopressin (AVP) levels were measured in plasma and cerebrospinal fluid (CSF) of rats during acquisition and retention of a passive avoidance response. Only 5 min after the onset of the retention session a significantly higher level of AVP was found in plasma of animals which displayed a long latency, as compared with the levels of animals which showed a weak passive avoidance response (short latencies), or no passive avoidance behavior at all (controls). Moreover no changes in plasma AVP levels were found in plasma of rats submitted to acquisition or extinction of an active avoidance response. It is suggested that, although an elevated plasma AVP level is associated with strong retention of a passive avoidance response the peripheral circulation as well as the CSF are of minor importance for the transport of this neuropeptide to its site of behavioral action.

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Section: Introductionmentioning

confidence: 69%

Vasopressin levels in peripheral blood and in cerebrospinal fluid during passive and active avoidance behavior in rats

Greidanus¹,

Croiset²,

Goedemans³

et al. 1979

Hormones and Behavior

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“…rats in various ways, many differences possibly associated secondarily with the loss of vasopressin. These include impaired growth (Haack, Homsy, Kohrs, Mohring, Oster & Mohring, 1975), an impaired ability to learn avoidance behaviour in response to noxious stimuli (Bohus, Van Wimersma Greidanus, & De Wied, 1975) and an impaired adrenal response to stress (McCann, Antunes-Rodriguez, Nallar & Valtin, 1966). This latter impairment may be particularly relevant since glucocorticoids appear to be necessary for the normal response to stress, such as the restitution of blood volume after haemorrhage (Gann & Pirkle, 1975).…”

Section: Resultsmentioning

confidence: 99%

The cardiovascular effects of vasopressin after haemorrhage in anaesthetized rats.

Chapman¹,

Hreash²,

Laycock³

et al. 1986

The Journal of Physiology

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SUMMARY1. The cardiovascular effects of an acute haemorrhage (2 % of the body weight)were studied over a 60 min period in three groups of rats: (a) Brattleboro rats with hereditary hypothalamic diabetes insipidus (b.d.i.) lacking circulating vasopressin, (b) control rats of the parent Long Evans (l.e.) strain, and (c) l.e. rats treated with an antagonist of the vascular action of vasopressin.2. Prior to the haemorrhage there were no significant differences between the three groups of rats with respect to mean arterial blood pressure, cardiac output, stroke volume or total peripheral resistance.3. Following the haemorrhage cardiac output and stroke volume were severely reduced in all three groups of rats. Total peripheral resistance was relatively unaffected in antagonist-treated l.e. rats and b.d.i. rats, but rose substantially in response to the loss of blood in the control l.e. group. Both total peripheral resistance and mean arterial blood pressure were markedly greater in the untreated l.e. control rats than in the other two groups of animals during the first 20 min after haemorrhage.4. The mean heart rate measured in Brattleboro rats was elevated compared with that of control l.e. rats throughout the experiment and, in addition, significantly greater than that of antagonist-treated l.e. rats during the first 40 min after the haemorrhage.5. Survival rate for the b.d.i. rats following the 2 % haemorrhage was lower than that for l.e. control rats and antagonist-treated l.e. rats.6. The results indicate that the recovery of the blood pressure following an acute arterial haemorrhage is significantly influenced by vasopressin, particularly during the first 20 min, and that the predominant effect of the hormone is to increase the total peripheral resistance. The higher mortality associated with volume depletion in the b.d.i. rats is unlikely to be directly related to the absence of the vascular action of vasopressin, since administration of the vasopressin antagonist to normal l.e. rats does not reduce their survival rate.

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“…Bohns et at. [3] and de Wied et at. [9] reported that homozygous Brattleboro rats showed faster extinction performance in shuttle box and pole jump active avoidance situations as well as decreased retention in a step-through passive avoid ance task.…”

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confidence: 99%

An Inability of Subcutaneous Vasopressin to Affect Passive Avoidance Behavior

Hostetter

Jubb

Kozlowski³

1980

Neuroendocrinology

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The effects of subcutaneous injections of vasopressin on the passive avoidance behavior of rats were investigated in an extensive study. 200 male Wistar rats were tested in a step-through passive avoidance task. The animals were assigned randomly to 1 of 20 experimental groups consisting of five vasopressin injection and four shock level conditions. Each animal was trained to enter a dark compartment, then subjected to 0.25, 0.10, 0.05 mA or no foot shock for 2 sec. 60 min prior to a retention test administered 24 h after the foot shock, each animal was given a single injection of 0.30, 0.12, 0.06, or 0.03 IU of vasopressin or of saline. Time to reenter the shock compartment was tested 24 and 48 h after the foot shock. Latencies in both retention tests indicated that, although there was a significant effect of shock level on latency scores, there was no effect of vasopressin with any dose level tested. The inability to find an effect of vasopressin in this study is contrary to results of other studies. Several factors, including general reactivity of the animals or the distribution system for vasopressin in the brain, might provide the underlying reason for these dramatic differences.

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Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain)

Cited by 165 publications

References 29 publications

Vasopressin levels in peripheral blood and in cerebrospinal fluid during passive and active avoidance behavior in rats

Vasopressin levels in peripheral blood and in cerebrospinal fluid during passive and active avoidance behavior in rats

The cardiovascular effects of vasopressin after haemorrhage in anaesthetized rats.

An Inability of Subcutaneous Vasopressin to Affect Passive Avoidance Behavior

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