The effectivity of cavity cleanser chlorhexidinegluconate 2% and saponin 0.78% of mangoosteen peel

Abstract

<jats:p>Background. Use of cavity cleanser is important before restoration the teeth to clean debris, residue of prepared dentine, blood, bacteria, collagen denaturized by teeth preparation. Nowadays, the cavity cleanser that people used still having shortcoming, one of which is the lack of ability to clean the root canal of the smear layer. Purpose. The purpose of this study examines the difference of cavity cleaner between saponin of mangoosteen peel (GarciniaMangostana L.) and chlorhexidinegluconate 2%. Method. Eighteen upper first premolar divided into 3 groups, each of them consist three tooth. Forming the preparation tooth cavity then group 1 using aquadest for control group, group 2 using chlorhexidinegluconate 2%, and group 3 using saponin of mangoosteen peel (GarciniaMangostana L.). For rating cleanliness of the tooth cavity using a scale of cleanliness conducted under Scanning Electron Microscope. Result. There was a significant difference (p &lt; 0.05) in One-Way ANOVA parametric test andpos hoc test between chlorhexidinegluconate 2 % and saponin of mangoosteen peel to the cleanliness of the tooth cavity. Conclusion.According to the result of the study, it can be concluded that saponin of mangoosteen peel (GarciniaMangostana L.) less effective for cleaning the tooth cavity than chlorhexidinegluconate 2%.</jats:p>

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“…17 Saponin juga mengandung asam karboksilat yang dapat meningkatkan kelarutan molekul dalam air. 13 Saponin bekerja sebagai pelarut organik yang akan bereaksi dengan asam lemak dan mengubahnya menjadi asam lemak (sabun) dan gliserol (alkohol), yang nantinya akan melarutkan smear layer organik dan anorganik secara bersamaan. Saponin memiliki struktur kimia berupa glikosida yang merupakan jenis senyawa polar dan triterpen yang merupakan senyawa nonpolar.…”

“…Hal ini disebabkan pembersihan smear layer dengan bahan asam dapat meningkatkan laju alir cairan yang akan masuk ke dalam tubuli dentin yang terbuka, hal ini dapat mengganggu daya adhesi karena sifat bahan resin yang hidrofobik tidak dapat beradhesi ke substrat yang bersifat hidrofilik. Hal ini Padjadjaran Journal of Dental Researchers and Students • Volume 7, Nomor 1, Bulan Februari Tahun 2023 sama dengan enelitian Siwinata dkk 13 yang menunjukkan bahwa saponin dari ekstrak mangga juga dapat membersihkan namun pembersihannya tidak sebaik chlorhexidine.…”

Antibacterial Effectiveness Test of Potato Peel Ethanol Extract (Solanum tuberosum L.) against Lactobacillus acidophilus: An In Vitro Study

“…Cavity cleanser is a material used to clean, wet, and disinfect cavities after preparation (Setianingrum et al, 2017). Cavity cleaning is done to remove debris, bacteria, and microbes that have settled on the prepared cavity walls, such as in the formed smear layer, dentinoenamel junction (DEJ), or the dentinal tubules (Setianingrum et al, 2017;Siwinata et al, 2020). An ideal cavity cleanser must have a low level of toxicity to the pulp cells without interfering with the adhesion of the restorative material (Setianingrum et al, 2017).…”

“…Chlorhexidine digluconate is considered effective as an antibacterial agent because it binds to the amino acids present in dentine and can kill bacteria within hours. The use of chlorhexidine digluconate as a cavity cleanser can reduce the risk of secondary caries and increase tooth sensitivity (Siwinata et al, 2020). Nonetheless, chlorhexidine digluconate has several limitations, including its incapability to dissolve organic tissue and its potential for causing allergies when exposed continuously for extended periods.…”

Viability Test of α-Mangostin against Oral Squamous Cell Carcinoma

“…α-Mangostin is a xanthone derivative that shows anticancer activity by stopping cell cycle and apoptosis, inhibiting cell proliferation, and reducing cancer invasion and metastasis. α-mangostin is also proven to inhibit cell viability and morphological changes in OSCC; however, the effective therapeutic concentration as an inhibitor of cell viability is still unclear (7)(8)(9). This study used in vitro culture to treat HOC313 cells with α-mangostin to evaluate the toxicity and viability of the cells.…”