The Effectiveness of Olive Oil in Controlling Morning Inflammatory Pain of Phalanges and Knees Among Women With Rheumatoid Arthritis: A Randomized Clinical Trial

Hekmatpou, Davood; Mortaji, Sepideh; Rezaei, Masoud; Shaikhi, Millad

doi:10.1097/rnj.0000000000000162

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Several studies have previously assessed the role of olive oil, olives, and nuts, alone or as components of the Mediterranean diet, in RA disease activity [ 20 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Except for one Iranian trial dealing with the efficacy of topical olive oil in controlling pain through skin absorption [ 42 ], the remaining trials considered a supplementary herbal formulation of olive oil, fig and olive fruits, together with routine DMARDs regimen (vs. routine DMARDs regimen alone) [ 43 ], or a combination of fish oil omega-3 fatty acids (3 grs/day) and 9.6 mL of olive oil (vs. fish oil omega-3 fatty acid (3 grs/day) or a soy oil placebo), in addition to the usual medication [ 41 ]. Indirect information on the potentially beneficial effects of olive oil may be obtained from trials investigating the effect of fish oil on RA disease activity [ 34 , 35 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Olive Oil and Nuts in Rheumatoid Arthritis Disease Activity

et al. 2023

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Few observational studies investigated the relationship between single food groups and disease activity in rheumatoid arthritis (RA). Within a recent Italian cross-sectional study (365 patients, median age: 58.46 years, 78.63% females), we focused on two food groups, olive oil and nuts, representing vegetable sources of fatty acids. Disease activity was measured with Disease Activity Score on 28 joints based on C-reactive protein (DAS28-CRP) and the Simplified Disease Activity Index (SDAI). Robust linear and logistic regression models included tertile-based consumption categories of each food group and several confounders. Stratified analyses were performed by disease severity or duration. Higher consumption of both food groups exerted a favorable effect on disease activity, significant only for olive oil (Beta: −0.33, p-value: 0.03) in the linear regression on the overall sample. This favorable effect was stronger in the more severe or long-standing forms of RA (p-value for heterogeneity <0.05, especially for disease severity). Significant ORs were as low as ~0.30 for both food groups, strata (i.e., more severe and long-standing RA), and disease activity measures. Mean DAS28-CRP significantly decreased by ~0.70 for olive oil and ~0.55 for nuts in the two strata; mean SDAI significantly decreased by 3.30 or more for olive oil in the two strata. Globally, the beta coefficients doubled, and the ORs halved (in absolute values) for both food groups, reaching significance in 12 of the 16 available models fitted to the more severe or long-standing RA strata. More compromised forms of RA may benefit from increasing consumption of olive oil, olives, and nuts.

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Section: Discussionmentioning

confidence: 99%

Olive Oil and Nuts in Rheumatoid Arthritis Disease Activity

et al. 2023

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“…A 2016 Cochrane systematic review on topical NSAIDs for chronic musculoskeletal pain was included [ 16 ]. This review was updated with an additional 42 studies: 14 compared to placebo [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ], four compared to oral NSAIDs [ 84 , 85 , 86 , 87 ], five compared to topical NSAIDs [ 88 , 89 , 90 , 91 , 92 ], and 19 compared to other topical drugs [ 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 ].…”

Section: Resultsmentioning

confidence: 99%

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Shi

Shao

et al. 2023

JCM

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(1) Background: Topical non-steroidal anti-inflammatory drugs (NSAIDs) are one of the primary drugs for treating musculoskeletal pain. However, there are currently no evidence-based recommendations about drug selection, drug administration, drug interactions, and use in special populations or other pharmacology-related content of such medications. To this end, the Chinese Pharmaceutical Association Hospital Pharmacy Professional Committee developed multidisciplinary guidelines on using topical NSAIDs to treat musculoskeletal pain. (2) Methods: The guidelines development process followed the World Health Organization guideline development handbook, the GRADE methodology, and the statement of Reporting Items for Practice Guidelines in Healthcare. The guideline panel used the Delphi method to identify six clinical questions to be addressed in the guidelines. An independent systematic review team conducted a systematic search and integration of evidence. (3) Results: Based on the balance between the benefits and harms of an intervention, the quality of the evidence, patient preferences and values, and resource utilization, the guideline panel developed 11 recommendations and nine expert consensuses on using topical NSAIDs to treat acute and chronic musculoskeletal pain. (4) Conclusions: Based on the effectiveness and overall safety of topical NSAIDs, we recommend patients with musculoskeletal pain use topical NSAIDs and suggest high-risk patients use topical NSAIDs, such as those with other diseases or receiving other concurrent treatments. The evidenced-based guidelines on topical NSAIDs for musculoskeletal pain incorporated a pharmacist perspective. The guidelines have the potential to facilitate the rational use of topical NSAIDs. The guideline panel will monitor the relevant evidence and update the recommendations accordingly.

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“…also, in the stusy Nakhostin-Roohi showed TOO can reduse female athletes Anterior Knee Pain [27]. In a study by Hekmatpou et al [28] which examined the effect of Olive Oil on knee pain in women with Rheumatoid Arthritis, it was shown that olive oil reduced pain in these patients [28]. Priyanga et al [29] study, which aimed to compare the effect of olive oil and heat treatment on pain in patients with knee pain, showed that the group using olive oil had less pain than the heat treatment group [29].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Topical Olive Oil on the Pain Intensity among Patients with Knee Osteoarthritis

Ghaysouri

Iri

Meisami

et al. 2021

JPRI

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Given the importance of relieving pain and disability experienced by the patients, the present study aimed to study the Effects of topical olive oil on the pain intensity among patients with knee osteoarthritis. The patients were randomly assigned into the experimental (28 patients) and control groups (27 patients). Firstly, in tropical olive oil (TOO) group, a high-quality olive oil, branded as Famila was used and in the control group, Diclofenac gel was applied. In experimental groups, 5 drops of herbal oils were applied to the knee thrice a day at morning, noon and evening and the knees were covered with a nylon sheet for more absorption. The patients were followed up for 4 weeks and their capability and pain intensities were evaluated prior the study, during the first week, the second week and the fourth week with Visual Analogue Scale. Data were analyzed using descriptive and analytical tests by SPSS V. 16 software. According to the findings, also the Mean (SD) pre-intervention Pain score in experimental group A was 8.10(0.91), which decreased to 1.78(0.78) after the intervention and in the control group from 8.55(0.69) to 3.85(0.98). Due to the greater effect of olive oil compared to Diclofenac gel on reducing pain of patients with KOA, it is recommended that patients use olive oil. Further studies are also recommended.

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The Effectiveness of Olive Oil in Controlling Morning Inflammatory Pain of Phalanges and Knees Among Women With Rheumatoid Arthritis: A Randomized Clinical Trial

Abstract: In comparison with other medical ointments for RA, olive oil has lower expenditure and is findable in many homes.

Cited by 7 publications

References 17 publications

Olive Oil and Nuts in Rheumatoid Arthritis Disease Activity

Olive Oil and Nuts in Rheumatoid Arthritis Disease Activity

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

The Effects of Topical Olive Oil on the Pain Intensity among Patients with Knee Osteoarthritis

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