The Effects of Topical Olive Oil on the Pain Intensity among Patients with Knee Osteoarthritis

Ghaysouri, Abas; Iri, Golbahar; Meisami, Amirhosein; Borji, Milad; Soltany, Behrouz

doi:10.9734/jpri/2021/v33i19b31335

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Olives have extensive application in ethnomedicine. It is used to treat diabetes 17) , hypertension 18) , pain 19) , inflammation 20) , gastrointestinal diseases, rheumatism, and resolve constipation. Because of these qualities, the European Pharmacopoeia (Ph.…”

Section: Introductionmentioning

confidence: 99%

Impact of Olive Oil Constituents on C-reactive Protein: <i>In silico</i> Evidence

et al. 2022

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or inhibitory effects, which aid in developing new and efficient therapeutics as lead molecules. VS exposes vast libraries of commercially available drug-like compounds that have been computationally tested against known structural targets and those projected to bind properly in experiments 7,8) .At numerous stages of drug development, pharmaceutical companies have made significant advancements in computer-aided drug design, including identifying new hits, enhancing molecule binding affinity in hit-to-lead, and lead optimization 9) . In addition, in silico approaches are frequently used in current drug design to assist in the knowledge of drug-receptor interactions. By exposing the mechanism of drug-receptor interactions, computational methodologies have been devised in the literature to Abstract: Pain is a sensation a humans sense as a protective mechanism against physical injury. This sensation is closely related to inflammation. It ranges from mild to highly obnoxious. It is well-known that the levels of the inflammatory biomarker, C-reactive protein (CRP), increase manifold in acute inflammation and pain. Olive oil, known to have many phytochemicals, has been traditionally used to alleviate pain. Amongst major phenolic compounds in olive oil are oleuropein (OLE), hydroxytyrosol (HT), tyrosol, and oleocanthal. Whether the analgesic and anti-inflammatory properties in olive oil are due to any specific interections is not known. Therefore, this study aimed to elucidate the possible anti-inflammatory and anti-nociceptive properties in those major phenolic compounds by using molecular docking software MOE 2015, comparing the energy value and binding site of phenolic compounds to that of well-known synthetic non-steroidal anti-inflammatory drugs (NSAIDs) and phosphocholine. The docking experiment showed that all compounds could directly interact with CRP. Oleuropein had the most potent interaction with CRP (-7.7580), followed by indomethacin (-6.0775), oleocanthal (-5.5734), ibuprofen (-5.3857), phosphocholine (-4.3876), HT (-4.2782), and tyrosol (-4.2329). Interestingly, the present study found other phytochemicals in olive oil that can be exploited as potential, safe, and cost-effective lead compound(s) for analgesic and anti-inflammatory activity, as supported by its molecular docking data.

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Section: Introductionmentioning

confidence: 99%

Impact of Olive Oil Constituents on C-reactive Protein: <i>In silico</i> Evidence

et al. 2022

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Unraveling the role of natural functional oils in modulating osteoarthritis related complications

Shabbir

Mehak

Khan

et al. 2023

Critical Reviews in Food Science and Nutrition

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Evaluation of polyherbal gel for musculoskeletal injuries in industrial workers

Ain,

Khan,

Raza

et al. 2024

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BACKGROUND: Industrial workers often have musculoskeletal disorders due to the nature of their work. OBJECTIVE: The goal was to investigate the scientific use of polyherbal gel in relieving pain and stiffness due to musculoskeletal injuries and improving activities of daily living (ADLs) in industrial workers. METHODS: A pragmatic, single-blinded, randomized control study divided 200 musculoskeletal injury patients into four parallel groups (n = 50). Groups 1 and 2 were applied polyherbal gel via phonophoresis with therapeutic ultrasound and superficial massage. Groups 3 and 4 received diclofenac diethyl-ammonium 1% gel by phonophoresis and superficial massage. The Global Pain Relief Scale, Numeric Pain Rating Scale (NPRS), and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were used to measure pain, stiffness, and ADLs. Data was analyzed using one-way analysis of variance (ANOVA) and paired t-test to compare mean±SD of four independent groups before and after gel application. The confidence interval was 95%, with p < 0.05 considered significant. RESULTS: The results revealed that polyherbal gel reduced pain (NPRS, WOMAC and Global pain relief scales) more efficiently (p≤0.000) when applied with phonophoresis as compared to applied with massage and standard diclofenac (p≤0.005), furthermore, polyherbal gel when applied with phonophoresis showed more efficient results. CONCLUSION: Industrial workers with musculoskeletal injuries benefited from the use of polyherbal gel for pain and inflammation relief. The polyherbal gel is natural, cost-effective, and easy to formulate.

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The Effects of Topical Olive Oil on the Pain Intensity among Patients with Knee Osteoarthritis

Cited by 3 publications

References 17 publications

Impact of Olive Oil Constituents on C-reactive Protein: <i>In silico</i> Evidence

Impact of Olive Oil Constituents on C-reactive Protein: <i>In silico</i> Evidence

Unraveling the role of natural functional oils in modulating osteoarthritis related complications

Evaluation of polyherbal gel for musculoskeletal injuries in industrial workers

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