The effectiveness of local anesthetics in preventing postoperative adhesions in rat models

Öztürk, Ersin; Yılmazlar, Aysun; Berhuni, Sait; Yılmazlar, Tuncay

doi:10.1007/s10151-010-0644-6

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…The quality of adhesions in the control group was significantly higher in comparison with that in the lidocaine 2% (6 mg/kg), bupivacaine and normal saline groups, and higher in the lidocaine 6 mg/kg group than in the bupivacaine group. In contrast, Ozturk et al (19) showed that the quality and quantity of adhesions in all groups were similar (P > 0.05). Perhaps one of the main reasons for this difference was the differences in dosages of the drugs.…”

Section: Discussionmentioning

confidence: 81%

“…Local anaesthetic drugs have recently been considered in this field. In a few studies using these drugs, satisfactory results have been reported (18,19). However, there is clearly a lack of adequate information in this area and further studies are needed to confirm the results and optimal usage of other drugs.…”

Section: Introductionmentioning

confidence: 85%

“…The severity of adhesions was evaluated by the presence of neovascularisations and their quality (the formation of thin or thick vessel walls). Based on studies done by Ozturk et al (19), who studied 10 rats in each group, and Yuzbasioglu et al, who studied 6 rats in each of their groups, a sample size of 10 rats in each group was chosen. To compare the differences in means between study groups, one-way ANOVA tests were performed.…”

Section: Methodsmentioning

confidence: 99%

“…Bupivacaine group: Peritoneal cavity was irrigated with 2 mg/kg of bupivacaine 0.25% (2 mg/kg, n = 10) before closing the laparotomy incision. Doses of each local anaesthetic drug were calculated according to the maximum permissible infiltration dose according to the guidelines supplied with each drug as previously described (19). Laparotomy incisions were closed using full thickness running 3.0 nylon sutures and the rats woke up spontaneously.…”

Section: Methodsmentioning

confidence: 99%

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Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

Parsa

Saravani

Sameei-Rad

et al. 2017

MJMS

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Background: Intra-abdominal adhesions are fibrous bands that develop after abdominal surgery or inflammation and cause mortality and morbidity following surgeries. This study aimed to assess the effects of bupivacaine, saline and two doses of lidocaine, after peritoneal lavage and to compare their effects in reducing abdominal adhesions in rat.Methods: In a blinded, randomised, placebo-controlled clinical trial, 50 female rats were anaesthetised and the parietal peritoneum was scratched to induce punctate bleeding. The rats were randomly assigned to five groups: saline, lidocaine 2% (3 and 6 mg/kg), bupivacaine 0.25% (2 mg/kg) and control (no irrigation). The peritoneal cavity was irrigated with the appropriate solution during laparotomy. Two weeks later, re-laparotomy was performed. The quantity, quality, severity and scores of adhesions were recorded and compared.Results: The quantity and quality of adhesions were significantly higher in the control group than in the lidocaine (6 mg/kg) and bupivacaine groups. The quality of the adhesions was higher in the normal saline group than in the lidocaine (6 mg/kg) and bupivacaine groups. The severity of adhesions between the lidocaine 3 and 6 mg/kg groups and between the lidocaine 3 mg/ kg and saline groups was lower than that in the control group.Conclusion: Using lidocaine (6 mg/kg) and bupivacaine lavage in first laparotomy reduces abdominal peritoneal obstruction because of the formation of adhesion bands.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

Parsa

Saravani

Sameei-Rad

et al. 2017

MJMS

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“…[4][5][6] Many adjuvants that prevent inflammation (steroidal and non-steroidal anti-inflammatory medications), degrade fibrin (recombinant tissue plasminogen activator [t-PA]), or act as barriers (absorbable material/ solution/gel or liquid paraffin) have been evaluated to prevent post-surgical adhesions. [7][8][9] Nevertheless, no definitive method or agent has been proven to prevent the formation of post-surgical adhesions.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of ClinOleic against post-surgical adhesions

Altınel¹,

Taşpinar²,

Özgüç³

et al. 2014

Ulus Travma Acil Cerrahi Derg

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Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

Guillaume

Teuschl

Gruber-Blum

et al. 2015

Adv Healthcare Materials

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Abdominal wall hernia is a recurrent issue world-wide and requires the implantation of over 1 million meshes per year. Because permanent meshes such as polypropylene and polyester are not free of complications after implantation, many mesh modifications and new functionalities have been investigated over the last decade. Indeed, mesh optimization is the focus of intense development and the biomaterials utilized are now envisioned as being bioactive substrates that trigger various physiological processes in order to prevent complications and to promote tissue integration. In this context, it is of paramount interest to review the most relevant bio-functionalities being brought to new meshes and to open new avenues for the innovative development of the next generation of meshes with enhanced properties for functional abdominal wall hernia repair.

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The effectiveness of local anesthetics in preventing postoperative adhesions in rat models

Abstract: Prilocaine and bupivacaine were found to decrease the severity of intra-peritoneal adhesions.

Cited by 8 publications

References 16 publications

Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

The protective effect of ClinOleic against post-surgical adhesions

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

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