2015
DOI: 10.1002/adhm.201500201
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Abstract: Abdominal wall hernia is a recurrent issue world-wide and requires the implantation of over 1 million meshes per year. Because permanent meshes such as polypropylene and polyester are not free of complications after implantation, many mesh modifications and new functionalities have been investigated over the last decade. Indeed, mesh optimization is the focus of intense development and the biomaterials utilized are now envisioned as being bioactive substrates that trigger various physiological processes in ord… Show more

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Cited by 30 publications
(33 citation statements)
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References 274 publications
(345 reference statements)
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“…Commonly used mesh prosthetic materials, such as polypropylene (PP), polyethylene-terephthalate (PET), and ePTFE, produce varying FBRs due to differing physiochemical properties on the surface of the implant [31]. Alternatively, biologically derived meshes are capable of displaying diminished FBR, particularly in the long term, due to their improved integration with neo-tissue and the presence of bioactive signals and growth factors within the bio-derived materials [33]. Moreover, researchers have deduced relationships between prosthesis design and host response that may act to counter some of the adverse reactions produced from the materials inherent chemical properties.…”
Section: Introductionmentioning
confidence: 99%
“…Abdominal adhesions are estimated to occur in 90% of all abdominal wall repair procedures and involve irregular fibrous strands that attach between tissues and organs within the abdominal cavity and the prosthesis [39]. The adhesions formed within the abdominal cavity progress to the formation of collagen dense extra-cellular matrix (ECM) which effectively closes the gap between internal viscera and prosthetic [33]. The occurrence of adhesions in hernia repair is predicated around the introduction of foreign bodies to injured peritoneal surfaces within the abdominal cavity [8, 40, 41].…”
Section: Introductionmentioning
confidence: 99%
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