Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

Parsa, Hossein; Saravani, Hengameh; Sameei-Rad, Fatemeh; Nasiri, Marjan; Farahaninik, Zahra; Rahmani, Amirhossein

doi:10.21315/mjms2017.24.3.4

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…In the literature, normal saline had already been reported to reduce adhesion formation in an experimental adhesion model [16]. On the other hand, several studies reported that there is no influence of saline on PPA prevention [18,19]. Normal saline is also commonly used in surgical practice for intra-operative lavage to remove contaminants and debris in order to prevent PPA.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Extractum Cepae, Heparin Sodium, and Allantoin in Experimental Peritoneal Adhesion

et al. 2020

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The purpose of the study is to investigate the effects of extractum cepae (EC), heparin sodium (HS), and allantoin (AA) on postoperative peritoneal adhesion (PPA) prevention. Forty-eight rats were allocated into six groups (n = 8). PPA was performed by Harris method. In group 1, no additional procedure was done. Abdominal cavity was washed with normal saline in group 2, EC in group 3, HS in group 4, AA in group 5, and EC-HS-AA mixture (EHA-m) in group 6. On the 21st postoperative day, PPA was scored with Nair adhesion score and examined for fibrosis histopathologically and hydroxy-proline levels (OHP) biochemically. Macroscopically, PPAwas decreased in groups 2, 4, and 6 compared to groups 1, 3, and 5 (p < 0.05) and decreased in group 2 compared to other groups (p < 0.05). Histopathologically, fibrosis was decreased in groups 2, 4, and 6 compared to other groups and decreased in group 2 compared to other groups (p < 0.05). Tissue OHP level was decreased in groups 2, 3, 4, and 5 compared to groups 1 and 6 (p < 0.05). Tissue OHP level was decreased in group 6 compared to group 1, but the difference was not statistically significant. PPA formation decreases with normal saline, HS and EHA-m, whereas increases with EC and AA both macroscopically and microscopically. Although HS and EHA-m seem to have adhesion prevention effect, washing the intestines with saline seems to be more effective.

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Section: Discussionmentioning

confidence: 99%

The Effect of Extractum Cepae, Heparin Sodium, and Allantoin in Experimental Peritoneal Adhesion

et al. 2020

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“…The ethanol extract of the plant has shown antibacterial effects against a number of grampositive (Listeria monocytogens, Staphylococcus aureus, and Staphylococcus epidermidis) strains [11]. Several studies have reported that Persica mouthwash has anti-plaque, anti-bleeding, anti-ulcer [12], analgesic and antimicrobial effects with no side effects from chemical mouthwashes [13]. Octacosanol, 1triacantanol, β-sitosterol, and β-sitosterol-3-O-β-Dglucopyranoside were isolated from the stem of the plant through phytochemical investigations [14].…”

Section: Introductionmentioning

confidence: 99%

The Difference in Mouthwash Side Effects of Persica and Chlorhexidine for Preventing Ventilator-induced Pneumonia among Patients Admitted to the Intensive Care Unit

Kiabi,

Baradari,

Kiasari

et al. 2023

TOPHJ

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Background: Pneumonia is a common cause of morbidity and mortality in ICU patients under mechanical ventilation. In recent years the use of herbal mouthwashes, due to antimicrobial effects and fewer side effects, has been studied in reducing the incidence of ventilator-associated pneumonia (VAP). In this study, the effect of Persica mouthwash in the prevention of VAP in ICU patients was compared with chlorhexidine. Methods: This study is a double-blind, randomized clinical trial among ICU patients under mechanical ventilation. Fifty patients were divided into two groups, the control group used 10 ml Chlorhexidine 2.0%, and the intervention group used 10cc Persica as a mouthwash. The incidence of pneumonia, mortality, length of hospital stays, mechanical ventilation duration, CPIS (Clinical Pulmonary Infection Score), and SOFA (sequential organ failure assessment) score and complications were evaluated among the two groups. Results: The incidence of pneumonia, mortality, SOFA score, and CPIS in the two groups were not significantly different. Length of stay in the ICU and mechanical ventilation duration were also not significantly different in the two groups, p>0.05. Side effects with chlorhexidine were significantly more often than Persica (44% vs. 8%) p=0.008. Conclusion: The incidence of early pneumonia in patients with no baseline pneumonia did not differ with Persica and Chlorhexidine mouthwash. At the same time, the incidence of side effects caused by the use of Persica was significantly less. Clinical Trial Registrations No.: RCT2017022032676N1.

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“…Frequent exposure to environments contaminated with these gases leads to cell damage, increased cell proliferation, hyperplasia, and ultimately tumor growth 21 . Studies have shown that inhaling more than 10 ppm of nitric oxide and more than 15 ppm of halothane and enluran can impair the functioning of the nervous system 22 , 23 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biochemical parameters in operating room staff exposed to radiation and anesthetic gases

Rezaei,

Salehi Zahabi,

darvishi

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Exposure to ionizing radiations and other hazardous agents such as anesthetic gases pose serious risks to the health of healthcare workers. This study aimed to evaluate the changes in blood and biochemical parameters of the operating room staff exposed to ionizing radiations and remnants of anesthetic gas. Methods: This cross-sectional study was performed at (XXX). The control group was selected from different parts of the hospital that were not exposed to ionizing radiations and anesthetics, including office, services, and treatment. The case group included all operating room personnel. Hematopoietic parameters such as complete blood count and WBC differential, parameters of liver function such as serum activity of liver enzymes (ALT, AST, ALP, LDH) and serum bilirubin levels, fasting blood sugar, serum lipid profile, level of vitamin D and magnesium were measured for the exposed and referent subjects. Additionally, a checklist was used to gather data regarding the occupational variables and medical histories of the studied subjects. Results: The mean values of Hb, Hct, Vitamin D, and MCHC, as well as the RBC count, were significantly lower in the exposed individuals than in the referent subjects. In contrast, the proportion of smokers was significantly higher in the exposed group than in the referent group. No significant differences were noted between exposed and unexposed groups as far as other parameters were concerned. However, no significant differences were noted between case and control groups as far as other measured parameters were concerned. Likewise, no significant differences were noted between exposed and referent groups as far as blood types, history of underlying diseases, work history, working hours per month, number of morning and evening shift hours, type of diet, consumption of high-fat diet a day before blood sampling, x-ray in the recent year, history of radiotherapy and therapeutic agents use was concerned. Conclusions: Exposure of operating room staff to ionizing radiations and waste anesthetics gases is associated with subtle, sub-clinical pre-pathologic decreases in some hematopoietic parameters such as hemoglobin, hematocrit and MCHC levels, RBC count as well as Vitamin D levels.

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Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

Cited by 7 publications

References 20 publications

The Effect of Extractum Cepae, Heparin Sodium, and Allantoin in Experimental Peritoneal Adhesion

The Effect of Extractum Cepae, Heparin Sodium, and Allantoin in Experimental Peritoneal Adhesion

The Difference in Mouthwash Side Effects of Persica and Chlorhexidine for Preventing Ventilator-induced Pneumonia among Patients Admitted to the Intensive Care Unit

Evaluation of biochemical parameters in operating room staff exposed to radiation and anesthetic gases

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