The effectiveness and safety of modest exercise in Japanese patients with chronic kidney disease: a single-armed interventional study

Hamada, Minako; Yasuda, Yoshinari; Kato, Shinichi; Arafuka, Hiroki; Goto, Motomitsu; Hayashi, Mutsuharu; Kajita, Etsuko; Maruyama, Shoichi

doi:10.1007/s10157-015-1147-6

Cited by 19 publications

(45 citation statements)

References 36 publications

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“…In the study supported by (Hamada, et al, 2016) who reported that modest physical exercise program will upgrade the physical functional status of CKD patients undergoing HD treatment and will not a reason for any functional deterioration of the renal functional tests, in addition the same authors reported that, the exercise program should be included in the routine care of stage 4, or 5 CKD patients [27]. Also (Stewart, 2017) supported that, the intradialytic exercise program may raise the efficiency of the dialysis treatment by improving the efflux of urea from the tissue to the vascular closet resulting in an increase in serum urea clearance [28].…”

Section: Discussionmentioning

confidence: 95%

Impact of Intradialytic Rehabilitation Program on General Health of Chronic Kidney Disease Patients

Elbaky¹,

Zaki²,

Amin³

et al. 2018

AJNR

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Background: CKD patients received intradialytic rehabilitation program developed improvement in their general health. Exercise also improve solute removal which increase the HD efficiency. Aim: to evaluate the impact of intradialytic rehabilitation program on general health of CKD patients. Design: Quasi experimental. Setting: The study conducted at hemodialysis unit of Minia urology hospital. Sampling: 60 patients divided in two groups 30 for each. Results: more than half of both groups were female. More than half of both group were diabetic and hypertensive. Mean age of both groups were (39.73 ± 8.17) & (40.00 ± 8.27). The 6 MWT was lower in the control group (325.3 ±24.1, 310.6 ±18.3 & 308 ±17.8) at the three observations than the study (352.3 ±46.8, 393.8 ±78.4 & 448 ±26.9). Small percentage of the rehabilitation group experienced dyspnea (16.6 % and 26 %). The study group showed improvement in mean serum creatinine (4.85± 0.54 & 4.58±0.54) than the control group (5.58± 0.68 & 5.58± 0.68). After rehabilitation program half of the study had low depression and only (13.3%) of them had high depression level. Conclusion: Intradialytic rehabilitation program for CKD patients enhance their activities of daily living abilities which improves their psychological health status.

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Section: Discussionmentioning

confidence: 95%

Impact of Intradialytic Rehabilitation Program on General Health of Chronic Kidney Disease Patients

Elbaky¹,

Zaki²,

Amin³

et al. 2018

AJNR

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“…Similarly, another study of 16 older adults with Stage 4 CKD demonstrated that 12 weeks of physical activity also improved performance on the ‘Get Up and Go’ test [ 13 ]. Six months of physical activity improved performance on the 30 second ‘Sit-to-Stand’ test in 47 persons with CKD [ 14 ]. Four studies demonstrated that a physical activity intervention of 12 or more weeks improved performance on the six meter walk test in CKD patients [ 12 – 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Chronic Kidney Disease on a Physical Activity Intervention: Impact on Physical Function, Adherence, and Safety

Liu

Milton

et al. 2016

J Clin Nephrol Ren Care

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Background Because chronic kidney disease (CKD) is associated with muscle wasting, older adults with CKD are likely to have physical function deficits. Physical activity can improve these deficits, but whether CKD attenuates the benefits is unknown. Our objective was to determine if CKD modified the effect of a physical activity intervention in older adults. Methods This is an exploratory analysis of the LIFE-P study, which compared a 12-month physical activity program (PA) to a successful aging education program (SA) in older adults. CKD was defined as a baseline eGFR < 60 mL/min/1.73 m2. We examined the Short Physical Performance Battery (SPPB) at baseline, 6 and 12 months. Secondary outcomes included serious adverse events (SAE) and adherence to intervention frequency. Linear mixed models were adjusted for age, sex, diabetes, hypertension, CKD, intervention, site, visit, baseline SPPB, and interactions of intervention and visit and of intervention, visit, and baseline CKD. Results The sample included 368 participants. CKD was present in 105 (28.5%) participants with a mean eGFR of 49.2 ± 8.1 mL/min/1.73 m2. Mean SPPB was 7.38 ± 1.41 in CKD participants; 7.59 ± 1.44 in those without CKD (p = 0.20). For CKD participants in PA, 12-month SPPBs increased to 8.90 (95% CI 8.32, 9.47), while PA participants without CKD increased to 8.40 (95% CI 8.01, 8.79, p = 0.43). For CKD participants in SA, 12-month SPPBs increased to 7.67 (95% CI 7.07, 8.27), while participants without CKD increased to 8.12 (95% CI 7.72, 8.52, p = 0.86). Interaction between CKD and intervention was non-significant (p = 0.88). Number and type of SAEs were not different between CKD and non-CKD participants (all p > 0.05). In PA, adherence for CKD participants was 65.5 ± 25.4%, while for those without CKD was 74.0 ± 22.2% (p = 0.12). Conclusion Despite lower adherence, older adults with CKD likely derive clinically meaningful benefits from physical activity with no apparent impact on safety, compared to those without CKD.

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“…Dietary change can influence on the amount of proteinuria (20,21). Excessive exercise can increase proteinuria temporarily (22), while modest exercise has a preferable effect on proteinuria in patients with stable CKD (23).…”

Section: Discussionmentioning

confidence: 99%

Influential factors on serum albumin concentration in hospitalized chronic kidney disease patients

et al. 2017

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: Background : Serum albumin concentration (SAC) is a prognostic factor that is affected by many factors such as postural change, liver function and food intake. Chronic kidney disease (CKD) patients excrete proteinuria, have low-protein diet, and receive glucocorticoid therapy. No one has evaluated the most influential factors on SAC in CKD patients. Methods : A retrospective study. Hospitalized CKD patients with less than 1 g/ gCreatinine proteinuria receiving glucocorticoid therapy (n=28), with 1 or more g/gCreatinine proteinuria not receiving glucocorticoid therapy (n=36), and with 1 or more g/gCreatinine proteinuria receiving glucocorticoid therapy (n =39) were enrolled. SAC, hemoglobin, proteinuria and blood pressure at the last outpatient check-up before hospitalization, on the second day of hospitalization, at the last laboratory examination before discharge, as well as at the first outpatient follow-up after discharge were analyzed. Results : SAC decreased on the second day of hospitalization and increased at the first outpatient follow-up significantly in all groups. Unexpectedly, the change of SAC was irrelevant to the amount of proteinuria. Conclusions : SAC was affected by not only proteinuria, but also postural change, physical activity, and food in CKD patients. SAC should be analyzed by standardizing a patient's condition during phlebotomy.

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The effectiveness and safety of modest exercise in Japanese patients with chronic kidney disease: a single-armed interventional study

Abstract: Our modest exercise program improved the physical performance of CKD patients without deterioration of renal function. These results suggest that exercise rather than excess rest should be recommended for CKD patients to avoid muscle wasting.

Cited by 19 publications

References 36 publications

Impact of Intradialytic Rehabilitation Program on General Health of Chronic Kidney Disease Patients

Impact of Intradialytic Rehabilitation Program on General Health of Chronic Kidney Disease Patients

The Effect of Chronic Kidney Disease on a Physical Activity Intervention: Impact on Physical Function, Adherence, and Safety

Influential factors on serum albumin concentration in hospitalized chronic kidney disease patients

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