Influential factors on serum albumin concentration in hospitalized chronic kidney disease patients

Abstract

: Background : Serum albumin concentration (SAC) is a prognostic factor that is affected by many factors such as postural change, liver function and food intake. Chronic kidney disease (CKD) patients excrete proteinuria, have low-protein diet, and receive glucocorticoid therapy. No one has evaluated the most influential factors on SAC in CKD patients. Methods : A retrospective study. Hospitalized CKD patients with less than 1 g/ gCreatinine proteinuria receiving glucocorticoid therapy (n=28), with 1 or more g/gCreatinine proteinuria not receiving glucocorticoid therapy (n=36), and with 1 or more g/gCreatinine proteinuria receiving glucocorticoid therapy (n =39) were enrolled. SAC, hemoglobin, proteinuria and blood pressure at the last outpatient check-up before hospitalization, on the second day of hospitalization, at the last laboratory examination before discharge, as well as at the first outpatient follow-up after discharge were analyzed. Results : SAC decreased on the second day of hospitalization and increased at the first outpatient follow-up significantly in all groups. Unexpectedly, the change of SAC was irrelevant to the amount of proteinuria. Conclusions : SAC was affected by not only proteinuria, but also postural change, physical activity, and food in CKD patients. SAC should be analyzed by standardizing a patient's condition during phlebotomy.

The utility and limitation of inferior vena cava diameter as a dry weight marker

“…There is a large overlap among outpatients with optimal DW and inpatients including !50% patients without practical DW (Figure 1, Table 3, 4). In addition, basically, inpatients have different nutritional status and hemodynamics with low serum albumin and hemoglobin concentration because of the change of diet and activity compared with outpatients (17). In this study, inpatients had lower serum albumin and hemoglobin concentration than outpatients ( Table 2).…”

“…The markers of DW such as IVCdexp, CTR (1), left ventricular end-diastolic diameter (LVDd) (16), left atrial diameter (LAD) (17) were analyzed to investigate the best marker of DW in outpatients. First, IVCdexp, LVDd and LAD were related to body surface area, so that the markers were influenced by body size.…”

The association between serum albumin and LOS of patients with acute heart failure: a retrospective study based on the MIMIV-IV database

“…For AHF patients with malignancy, liver cirrhosis, nephrotic syndrome, chronic kidney disease and sepsis, these comorbidities can affect the synthesis and concentration of albumin. [21][22][23][24] In subgroup analysis, it can be found that only sepsis had an impact on the relationship between serum albumin and LOS. Sepsis is systemic infectious disease that often leads to dysfunction of various organs of the body.…”