The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis

Li, Xinyi; Liu, Yan; Zheng, Yan; Wang, Peiyu; Zhang, Yumei

doi:10.3390/nu10030375

Cited by 183 publications

(122 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2017, a systematic review and meta-analysis reported that the dose of vitamin D supplementation ≥ 1000 IU/day had a reducing effect on FBG levels [37]. Recently, a systematic review and meta-analysis indicated that daily doses of vitamin D ≥ 2000 IU/day had a positive impact on glycemic control [43]. In relation to calcium, it is difficult to determine the insufficiency of calcium status by biochemical methods, but suboptimal intake of calcium has been reported in different populations [44,45].…”

Section: Discussionmentioning

confidence: 99%

“…In 2015, a systematic review reported that short-term supplementation of vitamin D supplementation had a beneficial effect on glycemic control [16]. Furthermore, a recent systematic review and meta-analysis indicated that high-dose and short-term supplementation of vitamin D alone had beneficial effects on insulin resistance and FBG [43]. However, in 2017, a systematic review and meta-analysis reported that neither short-term and nor long-term vitamin D supplementation has significant effect on FBG [46].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Calcium‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2019

View full text Add to dashboard Cite

We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of calcium-vitamin D co‑supplementation on insulin, insulin sensitivity, and glycemia. A systematic search was carried out in Web of Science, PubMed, EMBASE, Scopus, and Cochrane library without any language and time restriction up to 12 August 2018, to retrieve the RCTs, which examined the effect of calcium and vitamin D co-supplementation on fasting blood glucose (FBG), insulin, HOMA-B, HOMA-IR, and QUICKI. Meta-analyses were carried out using a random effects model, and I2 indexes were used to evaluate the heterogeneity. Search yielded 2225 publications. Twelve RCTs with 4395 patients were eligible. Results demonstrated that calcium and vitamin D co‑supplementation had significantly reducing effects on FBG, HOMA-IR and circulating levels of insulin. As the subgroup analysis demonstrated, short-term (≤12 weeks) calcium and vitamin D co‑supplementation had a significant reducing effect on FBG. However, beneficial effects of calcium and vitamin D co‑supplementation on circulating level of insulin and HOMA-IR were seen in both short-term and long-term (>12 weeks) supplementations. Furthermore, we found that high doses of vitamin D and calcium co-supplementation (vitamin D≥2000 mg/day and calcium≥1000 mg/day) had significantly reducing effects on FBG, HOMA-IR and insulin. Present meta-analysis indicated the beneficial effects of high-dose and short-term combined vitamin D and calcium supplementation on insulin, insulin resistance and glycemia; however, further large-scale RCTs with adequate and multiple dosing schedules are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Calcium‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Naghmeh Mirhosseini et al found that VD supplementation may significantly reduce FBG and HbA1c and facilitate glycemic control in type 2 diabetic patients [43]. However, Li et al didn’t find that VD supplementation would improve FBG or HbA1c [44]. Our meta-analysis assessed the effects of VD supplementation on glycemic control in DN patients, and showed that levels of FBG or HbA1c were not different between the experimental and the control group.…”

Section: Discussionmentioning

confidence: 77%

Effects of Vitamin D Supplementation on Renal Function, Inflammation and Glycemic Control in Patients with Diabetic Nephropathy: a Systematic Review and Meta-Analysis

Wang

Yang

Zhou

et al. 2019

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: Vitamin D (VD) is widely recognized as renal protective. However, whether VD supplementation provides benefit to patients with diabetic nephropathy (DN) remains controversial. Here, we performed a meta-analysis to systematically evaluate the impact of VD supplementation on indexes of renal function, inflammation and glycemic control in DN patients, and to explore the potential renal protective mechanism of VD. Methods: We searched Pubmed, Embase, Cochrane Library, and three major Chinese biomedical databases (CNKI, WANGFANG and VIP) for randomized controlled trials (RCTs) examining the effects of VD or its analogs in DN patients, published between September 2007 and July 2018. Quality assessment and data extraction were performed independently by two authors, according to the Cochrane systematic review methods. Meta-analysis based on the extracted results were performed via Revman 5.2 software. Results: We included 20 RCTs representing 1,464 patients with DN in this meta-analysis. VD supplementation significantly reduced 24-hour urine protein [MD = -0.26; 95% CI (-0.34, -0.17); P < 0.00001; I² = 95%], UAER [MD = -67.36; 95% CI (-91.96, -42.76); P < 0.00001; I² = 97%], hs-CRP [MD = -0.69; 95% CI (-0.86,-0.53); P < 0.00001; I² = 0%], TNF-α [MD = -56.79; 95% CI (-77.05, -36.52); P < 0.00001; I² = 89%] and IL-6 [MD = -0.73; 95% CI(-1.03, -0.44); P < 0.00001; I² = 0%]. However, VD supplementation failed to decrease SCr [MD = -0.83; 95% CI (-3.67,2.02); P = 0.57; I² = 0%] or increase eGFR [MD = 2.13; 95% CI (-2.06, 6.32); P = 0.32; I² = 0%]. In addition, VD supplementation showed no impact on indexes of glycemic control, such as HbA1c [MD = 0.01; 95% CI (-0.09, 0.11); P = 0.84; I² = 0%] and FBG [MD = -0.05; 95% CI (-0.29, 0.20); P = 0.70; I² = 0%]. Analysis of 24-hour urine protein, SCr, eGFR, hs-CRP or HbA1c revealed no difference between subgroups based on the type of VD supplementation, including calcitriol, alfacalcidol and vitamin D3, and the dose or duration of calcitriol usage. Conclusion: In patients with DN, VD supplementation provides beneficial effects on 24-hour urine protein and inflammation indexes, but not on SCr, eGFR or glycemic control indexes. More RCTs that comprehensively evaluate the impact of VD supplementation on indexes of renal function, inflammation and glycemic control in DN atients are required in order to reach conclusive results.

show abstract

“…Other recent systemic analysis also suggested that large dosage, short-term vitamin D supplementation was most likely to yield preferred changes in vitamin D deficient, non-obese groups, Asians, especially Middle Easterners, and patients with optimal glycemic control at baseline (8) Even though Sri Lanka is a tropical country with sufficient sunlight throughout the year, vitamin D insufficiency is not uncommon among our population. But data on vitamin D status in Sri Lankans are very few.…”

mentioning

confidence: 73%

Vitamin D supplementation in patients with type 2 diabetes

Karuppiah

Pathmanathan²

2019

Sri Lanka J. Diabetes Endocrinol. Metab.

View full text Add to dashboard Cite

Vitamin D, the so called sun-shine vitamin, is a hot topic currently, with number of studies proclaiming its benefits for several non-skeletal illnesses including cancer, cardiovascular diseases, autoimmune and inflammatory diseases, dementia, and diabetes. Conversely, recent studies have been more cautious and questioning its perceived benefits (1) .Along with numerous non-skeletal effects, vitamin D has received its attention on potential pancreatic beta cell function and insulin sensitivity. Historically the role of vitamin D in diabetes was recognized by a seasonal variation in glycemic control reported in patients with diabetes being worse in the winter. This may be due to insufficient vitamin D as a result of reduced sunlight in winter. Additional evidence supported the role of vitamin D in diabetes; presence of vitamin D receptors on pancreatic β cells, expression of 1α hydroxylase activity at pancreatic β cells causing activation of vitamin D, and increased transcription of insulin receptor genes by 1,25(OH)D (2). As β-cells in the pancreas are affected via cytokine-induced apoptosis, systemic inflammation has an important role in insulin resistance and cardiovascular events in patients with diabetes. Vitamin D could decrease the effects of systemic inflammation and protect β-cells. Other proposed mechanism where vitamin D affects insulin resistance is through the renin angiotensin aldosterone system (RAAS). Low levels of 1,25(OH)2D is shown to increase angiotensin II which inhibit the action of insulin in vascular and skeletal muscle tissues, leading to impaired glucose uptake (3) . Large number of cross-sectional studies have generally reported an inverse association between vitamin D status and prevalent hyperglycemia, favouring the biological perspective, where vitamin D have both direct and indirect effects on various mechanisms related to the pathophysiology of type 2 diabetes.The study by Forouhi et al. reported that the baseline serum vitamin D levels are inversely associated with glucose and insulin levels collected 10 years later(4). Finnish cohort study also showed an inverse association between baseline serum 25(OH) D and 17-year risk of type 2 diabetes, after adjustment for confounders like obesity and low physical activity (5) . A post hoc analysis of a trial designed for bone-related outcomes, found that 700 IU/day of Vitamin D3 (combined with calcium) decreased homeostasis model assessment of insulin resistance in participants with impaired glucose tolerance but not in those with normal fasting glucose. Numerous other prospective cohort studies have also demonstrated that higher vitamin D status was associated with reduced risk of type 2 diabetes. The important role of vitamin D in the development of diabetes evidenced by these epidemiological studies prompts clinicians to prescribe more and more vitamin D supplements. Subsequently several researches on the positive preventive effect of vitamin D supplementation were widely carried out. Number of randomized controlled trials study showed t...

show abstract

The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis

Cited by 183 publications

References 39 publications

Effect of Calcium‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Effect of Calcium‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Effects of Vitamin D Supplementation on Renal Function, Inflammation and Glycemic Control in Patients with Diabetic Nephropathy: a Systematic Review and Meta-Analysis

Vitamin D supplementation in patients with type 2 diabetes

Contact Info

Product

Resources

About