The Effect of Vitamin D Supplementation on Blood Lipids in Minorities with Type 2 Diabetes

Exebio, Joel C.; Ajabshir, Sahar; Campa, Adriana; Li, Tan; Zarini, Gustavo G.; Huffman, Fatma G.

doi:10.23937/2377-3634/1410093

Cited by 3 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were found by Exebio JC et al; a significant decrease in total cholesterol and triglycerides (P = 0.040, P = 0.037, respectively) was found after giving vitamin D supplement 6000 IU/day for six months. However, the effect of vitamin D supplementation can be mediated by other cofactors related to vitamin D metabolism, as the significance was lost after adjusting for confounders [27].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, significant improvement was noted in total cholesterol and LDL cholesterol levels (P = 0.05) in patients with T2DM [32]. Moreover, vitamin D deficiency is considered an additive factor in promoting atherosclerosis among T2DM patients [27,28]. Given the above, extensive studies exploring and investigating the association of vitamin D deficiency and its supplements among diabetic patients are required to identify its clinical significance for early management and prevention.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation of 25-Hydroxyvitamin D and Serum Lipid Levels Among Patients With Type 2 Diabetes

Elshebiny¹,

AlHewishel²,

Ghadeer³

et al. 2021

Cureus

View full text Add to dashboard Cite

Introduction Type 2 diabetes mellitus (T2DM) is a well-known health care problem. The is a growing interest in the role of vitamin D in metabolism including glucose and lipid metabolism. This study aims to investigate the possible association between 25-hydroxyvitamin D levels and serum lipid levels among patients with T2DM. Method A cross-sectional study was done at the King Faisal University Health Care Center in the Eastern Region of Saudi Arabia. Ethical approval was obtained from the Ethics and Research Committee at the College of Medicine, King Faisal University. We obtained the clinical and laboratory data of patients with T2DM by searching the electronic files of patients attending the center during the period between 2014 and 2021. Data collected included age, gender, nationality, vitamin D levels, HbA1c, and lipid levels. The chi-square and independent sample t-tests were applied when appropriate, for comparisons between groups to determine significance. A P-value of less than 0.05 was considered statistically significant. Result The study included 191 diabetic patients, 137 (71.7%) from Saudi Arabia, and 54 (28.3%) from other countries. Patient ages ranged from 21 to 100 years with a mean age of 56.2 ± 11.8 years. Cholesterol levels were observed to be high among 61 (32.3%) patients. Considering vitamin D, the average level among male patients was 26.526 ng/ml compared to 26 ng/ml% among females (P = 0.742). Conclusion Further long-term and more comprehensive randomized controlled trials are needed to make a firmer conclusion and stronger evidence on this beneficial role of vitamin D treatment on T2DM.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation of 25-Hydroxyvitamin D and Serum Lipid Levels Among Patients With Type 2 Diabetes

Elshebiny¹,

AlHewishel²,

Ghadeer³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…However, vitamin D activates lipoprotein lipase activity in adipocytes, resulting in a reduction of TG-enriched lipoprotein from the blood, thus reducing the risk of development of CVD [ 7 ]. Vitamin D receptors are present in the myocardial and vascular cells suggesting the involvement of vitamin D-mediated effect in the development of CVD [ 8 ]. Vitamin D has shown an effect in the lipid profile of the diabetic patient in some clinical research [ 5 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and cardiovascular risk in type 2 diabetes population

et al. 2021

View full text Add to dashboard Cite

This study aims to assess vitamin D deficiency-induced dyslipidemia and cardiovascular disease (CVD) risk in poor glycemic control among type 2 diabetes mellitus (T2DM) patients. This study was carried out among 455 T2DM patients involving poor glycemic control (n = 247) and good glycemic control (n = 208). Fasting plasma glucose (FPG) and HbA1c were measured to assess glycemic control. Cardiac risk ratio, atherogenic index plasma, and atherogenic coefficient were calculated to assess and compare the CVD risk in different groups. Patients with poor control had a significantly higher level of total cholesterol (TC), triglyceride (TG), and non-high-density lipoprotein lipase cholesterol (non-HDL-C), atherogenic variables, and lower level of high-density lipoprotein lipase cholesterol (HDL-C) as compared to patients with good glycemic control. We also observed significant negative correlation of vitamin D with lipid markers and atherogenic variables in poor glycemic control diabetic population. The serum vitamin D levels were inversely associated with HbA1c, FPG, TG, TC, and non-HDL-C. Furthermore, hypercholesterolemia, hypertriglyceridemia, and elevated non-HDL-C were the independent risks in hypovitaminosis D population. Vitamin D deficiency in poor glycemic control is likely to develop dyslipidemia as compared to vitamin D insufficient and sufficient groups. Thus, vitamin D supplementation and an increase in exposure to sunlight may reduce the risk of cardiovascular complications in diabetes.

show abstract

Vitamin D Deficiency in Patients with Diabetes in French Guiana: Epidemiology and Relation with Microvascular and Macrovascular Complications

et al. 2021

View full text Add to dashboard Cite

Vitamin D (VD) insufficiency is common among patients with diabetes in French Guiana. The study aimed to evaluate the prevalence of VD deficiency in the different type of diabetes encountered and to analyze the relationship between VD deficiency and diabetes complications. Methods: An observational study was conducted between May 2019 and May 2020 in French Guiana, based on data from the CODIAM study (Diabetes Cohort in French Amazonia), describing the characteristics of patients with diabetes mellitus. Among 600 patients enrolled with diabetes, 361 had an available VD assay. Results: The mean 25(OH)VD (hydroxycalciferol) level was 27.9 ng/mL. The level of VD was inversely proportional to the HbA1c (glycated hemoglobin) level. Patients with angina pectoris had a greater proportion of deficiencies VD < 20 ng/mL than those without angina. By contrast, patients with retinopathy had higher vitamin D concentrations than those without retinopathy. There was no association between vitamin D and arteriopathy, stroke, nephropathy and polyneuropathy. VD deficiency was more frequent in women, and in patients with a high school education. Conclusion: The prevalence of VD deficiency was high in patients with diabetes in French Guiana, emphasizing the importance of VD supplementation.

show abstract

The Effect of Vitamin D Supplementation on Blood Lipids in Minorities with Type 2 Diabetes

Cited by 3 publications

References 22 publications

Correlation of 25-Hydroxyvitamin D and Serum Lipid Levels Among Patients With Type 2 Diabetes

Correlation of 25-Hydroxyvitamin D and Serum Lipid Levels Among Patients With Type 2 Diabetes

Vitamin D deficiency and cardiovascular risk in type 2 diabetes population

Vitamin D Deficiency in Patients with Diabetes in French Guiana: Epidemiology and Relation with Microvascular and Macrovascular Complications

Contact Info

Product

Resources

About