Vitamin D deficiency and cardiovascular risk in type 2 diabetes population

Pokhrel, Sushant; Giri, Nisha; Pokhrel, Rakesh; Pardhe, Bashu Dev; Lamichhane, Anit; Chaudhary, Abhisek; Bhatt, Mahendra Prasad

doi:10.1515/biol-2021-0050

Cited by 9 publications

(8 citation statements)

References 35 publications

(38 reference statements)

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“…The literature supports the inverse relationship between AIP and vitamin D in our study. In another study, Pokhrel et al observed a significant negative correlation between vitamin D with lipid markers and atherogenic variables in a poor glycemic control diabetic population [ 53 ]. Some studies have shown that vitamin D supplementation improves dyslipidemia and atherogenic indices [ 54 ], and may be effective in preventing atherosclerosis [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Atherogenic Index of Plasma (AIP) and Its Association with Fatty Liver in Obese Adolescents

2023

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Background: The atherogenic index of plasma (AIP) is the base-10 logarithmic conversion of the triglyceride to high-density lipoprotein cholesterol ratio [AIP = log10 (triglyceride/HDL cholesterol)]. Some studies have found a link between low serum vitamin D levels, AIP, and fatty liver. This study was conducted to evaluate the relationship between AIP levels, fatty liver, and vitamin D levels in obese adolescents aged 10–17 years. Methods: This study included 136 adolescents, including 83 obese and 53 healthy controls, in the age range of 10–17 years. Thirty-nine of the obese adolescents had fatty livers. Those with ultrasonography grades 2 or 3 of fat were in the fatty liver group. The AIP value was calculated as the logarithmic conversion of the ratio (triglyceride/HDL cholesterol) at the base of 10. Vitamin D and other laboratory tests were analyzed biochemically. Statistical evaluations were made with the SPSS program. Results: The AIP, body mass index (BMI), homeostatic model assessment for insulin resistance (HOMA-IR), and insulin averages of obese adolescents with fatty liver were significantly higher than those of obese adolescents without fatty liver and the healthy control group (p < 0.05). Again, the mean AIP of obese patients without fatty liver was pointedly higher than that of the healthy control group (p < 0.05). There was a positive, moderate relationship between AIP and BMI, AIP and HOMA-IR, and AIP and insulin levels (p < 0.05), whereas there was a negative, moderate (37.3%) relationship between AIP and vitamin D (p = 0.019). Conclusion: AIP levels were higher in obese adolescents, and this increase was higher in obese adolescents with fatty liver in this study. Moreover, we detected a negative correlation between AIP and vitamin D levels and a positive correlation with BMI, insulin resistance, and insulin levels. Based on our data, we concluded that AIP can be a useful predictor of fatty liver in obese adolescents.

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Section: Discussionmentioning

confidence: 99%

Atherogenic Index of Plasma (AIP) and Its Association with Fatty Liver in Obese Adolescents

2023

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“…Vitamin D deficiency can increase the level of PTH , which can increase the risk of cardiovascular diseases such as myocardial hypertrophy and valve calcification by influencing lipid metabolism and increasing inflammation, insulin resistance, hypertension and other mechanisms [ 54 ]. A higher level of vitamin D can increase intestinal calcium absorption, inhibit the absorption of cholesterol, promote the excretion of cholesterol from feces, and reduce the formation of TG [ 55 ]. TAFA5 , CPB1 , and SLCO1B3 were the hub genes in the grey60 module.…”

Section: Discussionmentioning

confidence: 99%

WGCNA Analysis of Important Modules and Hub Genes of Compound Probiotics Regulating Lipid Metabolism in Heat-Stressed Broilers

Zhang

Jia

2022

Animals

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This study aimed to study compound probiotics’ (Lactobacillus casei, Lactobacillus acidophilus and Bifidobacterium) effects on production performance, lipid metabolism and meat quality in heat-stressed broilers. A total of 400 one-day-old AA broilers were randomly divided into four groups, each containing the same five replicates, with 20 broilers in each replicate. The control (21 °C) and experiment 2 were fed a basic corn–soybean meal diet. Experiment 1 (21 °C) and experiment 3 were fed a basic corn–soybean meal diet with 10 g/kg compound probiotics on days 7 and 28, respectively. The ambient temperature of experiment 2 and experiment 3 was increased to 30–32 °C (9:00–17:00) for 28–42 days, while the temperature for the other time was kept at 21 °C. The results showed that, compared with the control, the production performance and the content of high-density lipoprotein cholesterol in experiment 1 and triglyceride (TG) in experiment 2 increased (p < 0.05). Compared with experiment 2, TG decreased and the production performance increased in experiment 3 (p < 0.05). However, there was no significant change in meat quality indicators. Weighted gene co-expression network analysis (WGCNA) was used to analyze the intramuscular fat, abdominal fat and five blood lipid indicators. We found five related modules. Fatty acid biosynthesis, glycerolipid metabolism, and fat digestion and absorption were the pathways for KEGG enrichment. Additionally, NKX2-1, TAS2R40, PTH, CPB1, SLCO1B3, GNB3 and AQP7 may be the hub genes of compound probiotics regulating lipid metabolism in heat-stressed broilers. In conclusion, this study identified the key genes of compound probiotics regulating lipid metabolism and provided a theoretical basis for the poultry breeding industry to alleviate heat stress.

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“…Recently, the rise of serum levels of vitamin D is found to be associated with improvement of glucose tolerance and better control of diabetes; each rise of 1 ng/ml of vitamin D levels is associated with the decline of HbA1c percentage by 0.09%, signifying the key value of the rise of vitamin D in declining the risk of CVD complications in T2DM patients [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a multifunctional fat-soluble vitamin, consequences of de ciency of vitamin D might not only a ect musculoskeletal metabolism and functions, but it will modulate many other cellular events, such as immunological response, cell proliferation and di erentiation, insulin homeostasis, and metabolic functions as well [2]. us, it might play a vital role in the pathogenesis of insulin resistance, type 2 diabetes mellitus (T2DM), and cardiometabolic complications of T2DM patients [3]. By the e ect of UV light, 7-dehydrocholesterol (provitamin D 3 ) is converted into (cholecalciferol) vitamin D 3 that is transported to the liver with dietary vitamin D 2 to be hydroxylated by the enzyme P 450 vitamin D-25-hydroxylase into 25-hydroxyvitamin D. Furthermore, hydroxylation occurs in the kidney and to less extent in monocytes, placenta, and macrophages, by the enzyme (CYP27B1) 25 ere is growing evidence linking pathognomonic and molecular mechanisms of deficient vitamin D status with the development of T2DM, and it has been postulated that 1,25 dihydroxycholecalciferol or 1,25(OH) 2 D 3 may increase insulin sensitivity, thus resulting in the cellular responsiveness for transportation of glucose [5].…”

Section: Introductionmentioning

confidence: 99%

The Association between Vitamin D Hypovitaminosis and Cardiovascular Disease Risk in Saudi Diabetic Patients Type II

ALrefai

Elsalamony

Fatani

et al. 2022

Biochemistry Research International

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We evaluated the prevalence and association of Vitamin D deficiency with glycemic control and CVD risk in T2DM patients. Serum 25 (OH)D3, lipid profile, glucose panel, HbA1c, serum insulin, and HOMA-IR were assessed in 93 T2DM patients and 69 controls. 10 years and lifetime ASCVD risk scores were calculated. The levels of 25(OH)D3 were significantly low in T2DM patients compared to the control. T2DM patients with hypovitaminosis D displayed significantly increased FBG, insulin, and HOMA-IR compared to normovitaminosis. Their lifetime and 10-year ASCVD risk scores were significantly higher regardless of vitamin D deficiency levels ( P = 0.006 ; P = 0.023 ) in comparison to patients with sufficient levels of vitamin D. Among patients, the lifetime and 10 years of ASCVD risk showed a significant negative correlation with serum 25(OH)D3 and HDLc ( P = 0.037 ; 0.018) ( P = 0.0001 ), respectively, and significant positive correlation with T2DM duration, serum insulin, and HOMA-IR ( P = 0.018 ; 0.0001) ( P = 0.002 ; 0.001) ( P = 0.005 ; 0.001), respectively. The 10-year ASCVD risk exhibited a significant positive correlation with FBG ( P = 0.003 ) and HbA1c ( P = 0.009 ). T2DM duration was a predictor of vitamin D deficiency among T2DM patients (β = 0.22; CI = 0.002–0.04). There is a considerable association between lifetime and 10 years of ASCVD risk with hypovitaminosis D in T2DM, regardless of the deficiency levels which could be predicted by the diabetes duration.

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Vitamin D deficiency and cardiovascular risk in type 2 diabetes population

Cited by 9 publications

References 35 publications

Atherogenic Index of Plasma (AIP) and Its Association with Fatty Liver in Obese Adolescents

Atherogenic Index of Plasma (AIP) and Its Association with Fatty Liver in Obese Adolescents

WGCNA Analysis of Important Modules and Hub Genes of Compound Probiotics Regulating Lipid Metabolism in Heat-Stressed Broilers

The Association between Vitamin D Hypovitaminosis and Cardiovascular Disease Risk in Saudi Diabetic Patients Type II

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