Vitamin D Deficiency in Patients with Diabetes in French Guiana: Epidemiology and Relation with Microvascular and Macrovascular Complications

Girard, Elise; Bukasa-Kakamba, John; Fahrasmane, Aniza; Adenis, Antoine; Massicard, Mickael; Alsibai, Kinan Drak; Toffol, Bertrand De; Bekima, Raissa; Thelusme, Liliane; Okambabelle, Diana; Demar, Magalie; Aurelus, Jean M.; Sabbah, Nadia

doi:10.3390/nu13124302

Cited by 10 publications

(5 citation statements)

References 52 publications

(58 reference statements)

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“…[20,21,23,26,27,28,29,30,31,33,34] In several of them, there was also mention of an elevated risk of developing proliferative diabetic retinopathy. [26 ,27 ,31, 33, 34] However, according to a study conducted by Elise Girard et al, patients with DR had a higher median vitamin D concentration compared to those without DR. [22] In yet other studies, the results indicate that vitamin D concentration does not have an impact on the occurrence of the disease. [18] Despite discrepancies in some of the cited studies, we can conclude that lower vitamin D concentrations are likely associated with a more frequent occurrence of the mentioned retinal diseases.…”

Section: Discussionmentioning

confidence: 76%

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Association between deficient levels of vitamin D and the occurrence of selected retinal diseases

Żmijewska,

Maleszewska,

Sztybór

et al. 2024

J Educ Health Sport

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Introduction and Purpose: Vision originates in the eye's retina, a complex structure essential for processing visual information. The connection between nutritional inadequacy, particularly vitamin deficiencies, and overall health, including ocular health, has long been acknowledged. Recent studies highlight the potential impact of vitamin D, a crucial nutrient, on retinal health. The aim is to investigate the association between low levels of vitamin D and retinal diseases like age-related macular degeneration (AMD) and diabetic retinopathy (DR), and to evaluate the potential benefits of vitamin D supplementation or lifestyle changes for at-risk patients. Description of the State of Knowledge: AMD, a significant cause of blindness in the elderly, involves factors like oxidative stress and inflammation. Various stages of AMD require different treatments, with limited options for advanced stages. DR, a complication of diabetes, leads to conditions such as retinal ischemia and neovascularization. Both conditions are potentially influenced by vitamin D levels. Studies show mixed results regarding the impact of vitamin D on these diseases. Some suggest lower levels may increase risk, while others report no significant effect or even contradictory findings. Conclusions: While some studies indicate a potential association between low vitamin D levels and the occurrence of retinal diseases, discrepancies exist in the findings. Lower vitamin D concentrations may be linked to a higher frequency of AMD and DR, but the evidence is not consistent across all studies. Therefore, a more in-depth exploration of this subject is warranted to draw conclusive insights. It is crucial to consider supplementation or dietary changes in cases of vitamin D deficiency, given its potential impact on systemic health.

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Section: Discussionmentioning

confidence: 76%

“…Nevertheless, individuals with diabetic retinopathy exhibited significantly higher median vitamin D concentrations compared to those without retinopathy, with levels of 31 ng/ml versus 26 ng/ml, respectively. [22]…”

Section: Age-related Macular Degenerationmentioning

confidence: 99%

Association between deficient levels of vitamin D and the occurrence of selected retinal diseases

Żmijewska,

Maleszewska,

Sztybór

et al. 2024

J Educ Health Sport

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“…We have no clear explanation of why our U-shaped results are different from the more linear observations in Guadeloupe. Perhaps the high frequency of micronutrient deficiencies in French Guiana is such that some frequent deficiencies would be corrected by air particles (for example, airborne particles may contain Vitamin D and carotenoids, which may be absorbed through the lungs), but this is quite speculative (23)(24)(25)(26)(27)(28). The computation of the populationattributable fractions of the greatest values for different measures of exposure showed they ranged from 5.7% to 21.6%, depending on the outcome and the chosen exposure variable.…”

Section: Discussionmentioning

confidence: 99%

Desert dust episodes during pregnancy are associated with increased preterm delivery in French Guiana

Nacher,

Leneuve,

Basurko

et al. 2024

Front. Public Health

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Preterm deliveries are a major multifactorial public health problem in French Guiana. Desert dust episodes have been associated with preterm delivery in Guadeloupe, a territory with similarities to French Guiana. We thus tried to replicate this finding in the context of French Guiana. A retrospective ecological cohort study combined daily PM10 concentration measurements during pregnancy and term at delivery extracted from French Guiana’s computerized pregnancy delivery registry. Daily PM10 concentrations during the course of pregnancy were analyzed as mean concentrations and as the proportion of intense dust episodes (≥55 μg PM10/m3). These exposure variables were studied in relation to the outcome of preterm delivery. Overall, 3,321 pregnant women with complete daily PM10 measurements were included, of whom 374 (11.26%) delivered prematurely. Among preterm deliveries, 168 (44.9%) were spontaneous deliveries and 206 (55.1%) were induced. Rank-sum tests showed that, for spontaneous and induced spontaneous deliveries, both mean PM10 concentrations and proportions of intense desert dust episodes were significantly greater among preterm births than among term births. Although the proportion of intense desert dust episodes during pregnancy was significantly associated with spontaneous preterm deliveries, the relation was U-shaped, with an adjusted odds ratio (AOR) = 2 (95%CI = 1.2–3.1) for lowest values relative to median values and AOR = 5.4 (95%CI = 3.2–8.9) for the highest values relative to median values. Similarly, the proportion of intense desert dust episodes during pregnancy was also significantly associated with induced preterm deliveries in a U-shaped manner (AOR = 2.7 (95%CI = 1.6–4.5) for the lowest relative to median values and AOR = 6.8 (95%CI = 3.9–11.9) for the highest relative to median values). Although in our study the relation between PM10 concentrations appeared non-linear, the highest mean concentrations and intense desert dust episodes were indeed associated with both spontaneous and induced preterm delivery.

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“…Vitamin D deficiency is an independent risk factor for diabetic peripheral neuropathy (DPN) [39]. Maintaining adequate vitamin D status is critical in the prevention of diabetic microvascular complications [40 ▪ ,41]. Hypovitaminosis D could lead to neuropathic changes particularly on the lower limb nerves even in the early stages in pediatric type 1 diabetes mellitus (T1DM) [42].…”

Section: Vitamin Dmentioning

confidence: 99%

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen,

Song

2023

Current Opinion in Neurology

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Purpose of review Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, highlighting their pathophysiological and therapeutic roles. Recent findings The importance and clinical manifestations and implications of the vitamins and vitamin deficiencies are further demonstrated in peripheral neuropathy and the associated diseases. Vitamin deficiency is common in various severe and complex diseases such as diabetes, chemotherapy, acute nutritional axonal neuropathy, dermatitis, complex regional pain syndrome, postherpetic neuralgia, carpal tunnel syndrome, and so forth and some rare clinical case reports. There is evidence that deficiencies of almost all vitamins are associated with diabetic neuropathy. Vitamin supplementation may serve as an effective therapeutic strategy. Summary The vitamins play critical roles in maintaining physiological functions, and vitamin deficiencies cause peripheral neuropathy with various severe and complex diseases. The therapeutic benefits of vitamins and further understanding of the mechanisms for vitamin treatment effects should be emphasized and highlighted. More clinical trials are needed to establish optimal treatment strategies for vitamins in the various neuropathies. A large range of people/patients screening for vitamin deficiencies may be considered in order to provide early diagnosis and timely medical assistance.

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Vitamin D Deficiency in Patients with Diabetes in French Guiana: Epidemiology and Relation with Microvascular and Macrovascular Complications

Cited by 10 publications

References 52 publications

Association between deficient levels of vitamin D and the occurrence of selected retinal diseases

Association between deficient levels of vitamin D and the occurrence of selected retinal diseases

Desert dust episodes during pregnancy are associated with increased preterm delivery in French Guiana

Vitamins in neuropathy: pathophysiological and therapeutic roles

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