The effect of vitamin D on airway reactivity and inflammation in asthmatic children: A double‐blind placebo‐controlled trial

Abstract

In our small group of children with mild asthma, no difference could be demonstrated between the effect of vitamin D and placebo, despite significant increases in vitamin D blood levels. Larger interventional studies are needed to fully explore the possible effect of vitamin D in asthma.

Improved control of childhood asthma with low‐dose, short‐term vitamin D supplementation: a randomized, double‐blind, placebo‐controlled trial

“…For example, asthma that starts in adulthood differs from childhood-onset asthma in that it is often nonatopic, more severe, and associated with a faster decline in lung function (26). More recently, in Israel, vitamin D supplementation was reported to have no significant effects compared with placebo on changes of IgE, fractional exhaled nitric oxide, 20% reduction in FEV 1 , or cytokines in exhaled breath condensate (27). Again, there are several differences in study design between that RCT and our study.…”

Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma

“…44 Two recent interventional studies with vitamin D supplementation failed to show improvement in asthma control. 36,45 When vitamin D values were categorized as sufficient (Ͼ 30 ng/mL), insufficient (20 -30 ng/mL), and deficient (Ͻ 20 ng/mL), similar results were observed. Of note, serum vitamin D cutoff levels were determined for bone health use, whereas in nonbone-related conditions, there are still no optimal levels for disease prevention.…”

“…This result is supported by a large population sample (1,315 children) that failed to demonstrate significant association between serum 25-hydroxyvitamin D levels and F ENO , 29 and a recent interventional study that failed to demonstrate an effect of vitamin D administration on F ENO levels. 36 It should be noted that although F ENO is considered to be a marker of eosinophilic inflammation, its value is still under debate.…”

Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies

“…There was no change in IgE, eosinophil count, high sensitivity C reactive protein, fraction of exhaled nitric oxide levels or provocation dose of methacholine require to induce a 20% drop in FEV 1 between he vitamin D or placebo groups. Exhaled breath condensate cytokines, including IL4, IL5, IL10, IL17, and interferon gamma changed in both groups but there was no difference [11].…”