Improved control of childhood asthma with low‐dose, short‐term vitamin D supplementation: a randomized, double‐blind, placebo‐controlled trial

Tachimoto, Hiroshi; Mezawa, Hidetoshi; Segawa, Takaaki; Akiyama, Nobutake; Ida, Hiroyuki; Urashima, Mitsuyoshi

doi:10.1111/all.12856

Cited by 80 publications

(109 citation statements)

References 27 publications

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“…Significant improvement of asthma control in the vitamin D group (54 children), as compared to placebo group (35 children), was observed in Japanese schoolchildren. Short-term, low-dose supplementation of vitamin D as addition to standard asthma therapy may improve asthma control in schoolchildren [24].…”

Section: Childrenmentioning

confidence: 99%

“…Interestingly, no changes in www.journals.viamedica.pl parameters of asthma in comparison to the placebo group were found [26]. Improvement in asthma control was also revealed in children supplemented with 800 IU/d vitamin D for 2 months -according to the results of the study from Japan assessing severity and frequency of asthma [24]. Moreover, vitamin D supplementation was proposed as an adjunct to standard asthma treatment [27].…”

Section: Childrenmentioning

confidence: 99%

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Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Szymczak

Pawliczak

2018

Advances in Respiratory Medicine

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Asthma -a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients. Thus, it provides positive relation between vitamin D and asthma. Increased prevalence of asthma over the past decades causes elevated interest in vitamin D supplementation that is even reported as a ,,potential therapeutic option''. Unfortunately, results of clinical trials are inconsistent and do not provide supportive information about positive role of vitamin D in asthma. Little or even no effect of supplementation of vitamin D in improvement of onset, symptoms or progression of asthma was found in comprehensive interventional studies in adults, children and pregnant woman. This review critically summarized the last years evidence of a relation between vitamin D and asthma in adults, children and pregnant women.

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Section: Childrenmentioning

confidence: 99%

Section: Childrenmentioning

confidence: 99%

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Szymczak

Pawliczak

2018

Advances in Respiratory Medicine

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“…56 Enfermedades neurológicas Suplemento de VD3 entre 800 y 1000 UI/día. que los niños eutróficos para lograr las mismas concentraciones de 25(OH)D. 17 Considerando el efecto que tiene la adiposidad sobre la biodisponibilidad de VD, los países del centro de Europa han emitido recomendaciones específicas para niños y adolescentes obesos: suplemento de 1200-2000 UI por día (30-50 μg/día) dependiendo de la gravedad de la obesidad durante otoño e invierno; sin embargo, es recomendable durante todo el año si la síntesis cutánea no es suficiente durante el verano.…”

Section: Asmaunclassified

Deficiencia de vitamina D en la práctica clínica pediátrica

2018

Arch Argent Pediatr

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“…The meta -analysis could not show a beneficial effect of vitamin D supplementation on the prevention of asthma exacerbation, fractional exhaled nitric oxide levels, FEV 1 %, or asthma symptoms. 74 A more recent meta -analysis of RCTs on the use of vitamin D supplementation in asthma 82 included 9 clinical studies, 7 of which were conducted in 435 children 76,77,[83][84][85][86][87] and 2 in 658 adults. …”

mentioning

confidence: 99%

“…79,80,82 In addition, vitamin D significantly reduced the risk of patients having at least 1 emergency visit or hospitalization for an exacerbation (OR, 0.39; 95% CI, 0.19-0.78). 77,79,80,82,84,87 These effects are mainly attributable to studies performed in adults. Therefore, generalization of these results to children should be done with caution.…”

mentioning

confidence: 99%

Vitamin D supplementation in respiratory diseases - evidence from RCT

Mathyssen¹,

Gayan‐Ramirez²,

Bouillon³

et al. 2017

Polish Archives of Internal Medicine

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Pulmonary diseases are one of the most important causes of morbidity and mortality. Although vitamin D is best known for its role in calcium, phosphorus, and bone homeostasis, it has gained attention in the recent years because of a wide range of extraskeletal effects, including its immunomodulatory and antibacterial potential. Vitamin D deficiency is highly prevalent in chronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, tuberculosis, and asthma, and several clinical studies have been conducted investigating the effect of vitamin D supplementation on disease outcomes. In this review, we searched for positive evidence on vitamin D supplementation from randomized controlled trials and elaborated on the optimal serum vitamin D levels and dosing regimens for an effective intervention. While vitamin D supplementation seems to be beneficial as an add -on treatment for adult patients with asthma and a potent intervention to reduce exacerbations in patients with COPD, there is little evidence for its therapeutic use in cystic fibrosis, pneumonia, and tuberculosis. the debate on the appropriate levels of 25(OH)D is still ongoing, most studies define the levels of less than 20 ng/ml (50 nmol/l) as deficient because they are associated with chronic diseases. 5 This is also the threshold used in most governmental guidelines for vitamin D. 16 The levels below 10 ng/ml (25 nmol/l) are considered as severe deficiency because they are associated with an increased risk of rickets or osteomalacia. It is also assumed that patients with these levels exhibit a true risk for infections and chronic diseases. 17 Other research groups reported that the serum 25(OH)D concentrations of 30 ng/ml (75 nmol/l) or even higher, as found in native populations living around the equator, are needed for optimal health. 5,10 Importance of vitamin D in pulmonary diseases Vitamin D deficiency is associated with multiple diseases such as cancer, hypertension, and autoimmune diseases, but also with several lung diseases. 5 A recent meta -analysis demonstrated that vitamin D levels are significantly lower in patients with tuberculosis (TB) compared with controls (apart from the African population). 18 About 70% to 90% of patients with TB have 25(OH)D levels below 20 ng/ml. 19,20 Janssens et al 6 demonstrated that patients with COPD had significantly lower 25(OH)D levels compared with healthy smokers and that vitamin D deficiency correlated with disease severity. While 31% of the healthy smokers were vitamin D deficient, this percentage increased gradually to 60% in stage 3 of COPD according to the Global Initiative for Obstructive Lung Disease (GOLD) to even 77% in the most severe stage of the disease.Vitamin D deficiency is also highly prevalent in CF. Up to 75% of adults and 95% of pediatric patients with CF are vitamin D deficient, [21][22][23] despite routine oral supplementation. 24 In patients with CF, vitamin D deficiency seems to be associated with a decreased pulmonary function in adult...

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Improved control of childhood asthma with low‐dose, short‐term vitamin D supplementation: a randomized, double‐blind, placebo‐controlled trial

Abstract: Low-dose, short-term vitamin D supplementation in addition to standard treatment may improve levels of asthma control in schoolchildren.

Cited by 80 publications

References 27 publications

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Deficiencia de vitamina D en la práctica clínica pediátrica

Vitamin D supplementation in respiratory diseases - evidence from RCT

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