Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma

Dabbah, Husein; Yoseph, Ronen Bar; Livnat, Galit; Bentur, Lea

doi:10.4187/respcare.03763

Cited by 15 publications

(18 citation statements)

References 46 publications

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“…In a recently concluded study aimed at assessing the correlation between vitamin D levels and asthma and allergy markers in non-obese asthmatic children currently not receiving anti-inflammatory treatment, it was found that although the median level of vitamin D was 23 ng/ml, there was no correlation between vitamin D level and airway reactivity, airway inflammation and allergy. 42 The World Allergy Organization has recently reported that based on currently available evidence, they found no support for the hypothesis that vitamin D supplementation reduces the risks of developing allergic diseases in children. The panel suggested not using vitamin D in pregnant women, breastfeeding mothers or healthy infants as a means of preventing the developing of allergic diseases.…”

Section: Childrenmentioning

confidence: 99%

“…8,13,42,43 Recently, analysis of 25(OH)D levels in preschoolers aged 1–4 years with asthma as well as healthy subjects showed a significant decrease in vitamin D serum levels of asthmatic children when compared to controls. In the vitamin D sufficient group, total number of exacerbations during the previous year was much lower compared to the vitamin D insufficient group.…”

Section: Childrenmentioning

confidence: 99%

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Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

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Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations and overall worse outcomes in patients with asthma. Given the increase in the prevalence of asthma over the last few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Several studies have found that low serum levels of vitamin D (< 20 ng/ml) are associated with increased exacerbations, increased airway inflammation, decreased lung function and poor prognosis in asthmatic patients. Results from the in vitro and in vivo studies in animals and human have suggested that supplementation with vitamin D can ameliorate several hallmark features of asthma. However, the findings obtained from clinical trials are controversial and do not unequivocally support the beneficial role of vitamin D in asthma. Largely, interventional studies in children, pregnant women and adults have primarily found little-to-no effect of vitamin D supplementation on improved asthma symptoms, onset or progression of the disease. This could be related to the severity of the disease process and other confounding factors. Despite the conflicting data obtained from clinical trials, vitamin D deficiency does influence the inflammatory response in the airways. Further studies are needed to determine the exact mechanisms by which vitamin D supplementation may induce anti-inflammatory effects. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in bronchial asthma.

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Section: Childrenmentioning

confidence: 99%

Section: Childrenmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

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“…Some studies have found association between a decreased level of vitamin D and exacerbation of symptoms in asthmatic children [4,10,19,20]. The results of the Puerto Rican children study have shown that vitamin D insufficiency may be associated with elevated odds of asthma exacerbations independently of time spent outdoors, severity and control markers of disease, atopy, African racial ancestry [21].…”

Section: Childrenmentioning

confidence: 99%

“…No relation between the level of vitamin D and airway inflammation, airway reactivity as well as allergy has been found in non-obese, not receiving anti-inflammatory treatment children with asthma [20]. The findings from meta-analysis have shown that the relation between the level of vitamin D and the incidence of asthma, asthma control and lung functions are inconclusive.…”

Section: Childrenmentioning

confidence: 99%

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Szymczak

Pawliczak

2018

Advances in Respiratory Medicine

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Asthma -a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients. Thus, it provides positive relation between vitamin D and asthma. Increased prevalence of asthma over the past decades causes elevated interest in vitamin D supplementation that is even reported as a ,,potential therapeutic option''. Unfortunately, results of clinical trials are inconsistent and do not provide supportive information about positive role of vitamin D in asthma. Little or even no effect of supplementation of vitamin D in improvement of onset, symptoms or progression of asthma was found in comprehensive interventional studies in adults, children and pregnant woman. This review critically summarized the last years evidence of a relation between vitamin D and asthma in adults, children and pregnant women.

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“…1 In children with asthma, low vitamin D levels have been associated with decreased lung function 2 and airway hyperresponsiveness (AHR), 3,4 but there are contradictory results. 1,5 In young wheezing children, vitamin D insufficiency has been linked to exacerbations requiring treatment with oral corticosteroids. 6 High-sensitivity C-reactive protein (hs-CRP) is a biomarker reflecting low-grade systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%