The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial

El-Aal, A. Abd; El-Ghffar, Eman A. Abd; Ghali, Asmaa Abu; Zughbur, Mohammed R.; Sirdah, Mahmoud M.

doi:10.1016/j.dsx.2018.03.013

Cited by 59 publications

(38 citation statements)

References 28 publications

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“…In agreement with the present study, a 4‐month magnesium supplementation to prediabetic patients with hypomagnesemia significantly decreased FPG, insulin and triglycerides, and significantly increased HDL‐cholesterol levels . Moreover, a 3‐month supplementation with vitamin E and/or vitamin C to male individuals with T2DM which were under metformin treatment led to a significant reduction in FPG, insulin levels and HOMA‐IR, and a significant rise in QUICKI . Moreover, coadministration of magnesium and vitamin E supplements to obese rat reduced triglycerides levels better than vitamin E alone .…”

Section: Discussionsupporting

confidence: 91%

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Afzali

Kashi

Momen‐Heravi

et al. 2019

Wound Repair Regeneration

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This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Compared with the placebo, taking magnesium plus vitamin E supplements reduced ulcer length (β [difference in the mean of outcomes measures between treatment groups] −0.56 cm; 95% CI, −0.92, −0.20; p = 0.003), width (β −0.35 cm; 95% CI, −0.64, −0.05; p = 0.02) and depth (β −0.18 cm; 95% CI, −0.33, −0.02; p = 0.02). In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −13.41 mg/dL; 95% CI, −20.96, −5.86; p = 0.001), insulin (β −1.45 μIU/ml; 95% CI, −2.37, −0.52; p = 0.003), insulin resistance (β −0.60; 95% CI, −0.99, −0.20; p = 0.003) and HbA1c (β −0.32%; 95% CI, −0.48, −0.16; p < 0.003), and a significant elevation in insulin sensitivity (β 0.007; 95% CI, 0.003, 0.01; p < 0.001) compared with the placebo. Additionally, compared with the placebo, taking magnesium plus vitamin E supplements decreased triglycerides (β −10.08 mg/dL; 95% CI, −19.70, −0.46; p = 0.04), LDL-cholesterol (β −5.88 mg/dL; 95% CI, −11.42, −0.34; p = 0.03), high sensitivity C-reactive protein (hs-CRP) (β −3.42 mg/L; 95% CI, −4.44, −2.41; p < 0.001) and malondialdehyde (MDA) (β −0.30 μmol/L; 95% CI, −0.45, −0.15; p < 0.001), and increased HDL-cholesterol (β 2.62 mg/dL; 95% CI, 0.60, 4.63; p = 0.01) and total antioxidant capacity (TAC) levels (β 53.61 mmol/L; 95% CI, 4.65, 102.57; p = 0.03). Overall, magnesium and vitamin E co-supplementation for 12 weeks to patients with DFU had beneficial effects on ulcer size, glycemic control, triglycerides, LDL-and HDL-cholesterol, hs-CRP, TAC, and MDA levels.The diabetic foot ulcer (DFU) is a chronic consequence of diabetes mellitus which mainly caused by neuropathy, different grades of ischemia, and infection that coincide with poor glycemic control and diminished neutrophil function. 1 The mortality rate among diabetic patients with DFU is higher than twofold compared with nonulcer patients. 2 Based on the previous evidence, the effective management of diabetes and timely treatment of foot ulcer are implicated for decrease the morbidity and mortality of DFU. 3 The nutritional status of diabetic patients correlates with the severity of ulcer and play an important role in the reversing of wound risk. 4 According to the prior studies, the alternation of magnesium metabolism is a common feature in diabetic patients which interference with glycemic control and contributes to impaired insulin sensitivity and chronic inflammatory status. 5In addition, observational evidence shown that there is an inverse association between magnesium levels and the occurrence of foot ulcers, nephropathy and retinopathy. 6 Similarly, it is repo...

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Section: Discussionsupporting

confidence: 91%

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Afzali

Kashi

Momen‐Heravi

et al. 2019

Wound Repair Regeneration

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“…Of note, "multifactormulti treatments" might be more effective since there might be an additional or a synergistic benefit from two agents with acceptable safety and efficacy, for example the combination of treatments (traditional treatment plus antioxidants treatment) to achieve better effects than antioxidants only. Interestingly, a recent trial showed that middle-aged type 2 diabetic patients who received metformin treatment plus vitamin E and/or vitamin C had significantly improvement of glucose measures as well as lipid profiles compared to patients with metformin treatment alone, indicating that antioxidants use might be an adjuvant therapy in the management in type 2 diabetic patients (El-Aal et al, 2018). But the combination use still requires additional efforts.…”

Section: Remarks and Conclusionmentioning

confidence: 99%

Ageing, age-related diseases and oxidative stress: What to do next?

Luo

Mills

Cessie

et al. 2020

Ageing Research Reviews

350

202

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Although vitamins E is considered relatively safe compared to other fat-soluble vitamins (Tappel, 1972), mortality progressively increased for approximately greater than 150 IU/d which lower than the tolerable upper intake level for vitamin E, which is currently designated at 1,000 mg of any form of supplementary α-tocopherol per day (corresponding to 1,100 IU of the synthetic vitamin E per day or 1,500 IU of natural vitamin E per day) (Lim et al., 2005). In general, Vitamin E are used as drug for treatment some clinical problems as muscular dystrophies and some nervous disease (Bicknell, 1940), male infertility (Keskes-Ammar et al., 2003), nervous disease (Muller et al., 1983), cardiovascular disease (Lee et al., 2005), lowering blood triglyceride (Engelhard et al., 2006), improvement in insulin action and in diabetic patients (El-Aal et al., 2018; Panda et al., 2018; Pavithra et al., 2018), inhibition of platelets adhesion (Steiner, 1991) and aging (Chen et al., 2005; Mocchegiani et al., 2014). Many physicians use vitamin E randomly for patients (Vivekananthan et al., 2003).…”

Section: Introductionmentioning

confidence: 99%

Study of the toxic effect and safety of vitamin E supplement in male albino rats after 30 days of repeated treatment

El-Hak

ELaraby

Hassan

et al. 2019

Heliyon

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The aim of these investigations was to study vitamin E supplement effect in male albino rats after 30 days of repeated treatment. Four groups of six male rats were orally administered distilled water (control), 500, 1000 and 2000 mg/kg body weight vitamin E daily for 30 days. The impact of the treatment on percent body weight and mortality was determined and compared to the control group. Some hematological analysis, biochemical parameters and histological examination of different body organs were assessed. The rats treated with different doses of vitamin E supplement showed no deaths recorded in 30 days. The treatment with higher dose Vitamin E supplementation" caused significant alteration at the hematological, biochemical and histological level. Therefore, oral administration of vitamin E supplement in rats for 30 days was not safe for the liver and kidney and in the other hand, safe for the testes therefore that side effect on the liver and kidney should be considered when recommended vitamin E for therapeutic purpose. Care should be taken in taking high doses of vitamin E.

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The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial

Cited by 59 publications

References 28 publications

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Ageing, age-related diseases and oxidative stress: What to do next?

Study of the toxic effect and safety of vitamin E supplement in male albino rats after 30 days of repeated treatment

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