2019
DOI: 10.1111/wrr.12701
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Abstract: This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Compared with the placebo, taking magnesium plus vitamin E s… Show more

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Cited by 45 publications
(45 citation statements)
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References 49 publications
(57 reference statements)
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“…In another 12-week RCT, Afzali et al (2019) studied the effects of 250 mg/day Mg oxide + 400 IU vitamin E in 57 patients with diabetic foot. The intervention group exhibited a decrease in TG ( p = 0.04) and LDL-C ( p = 0.03), as well as an increase in HDL-C ( p = 0.01) [ 96 ]. In a cross-sectional study, Brandao-Lima et al (2019) researched the impact of zinc, potassium, calcium, and Mg administration at different concentrations in 95 T2DM patients.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In another 12-week RCT, Afzali et al (2019) studied the effects of 250 mg/day Mg oxide + 400 IU vitamin E in 57 patients with diabetic foot. The intervention group exhibited a decrease in TG ( p = 0.04) and LDL-C ( p = 0.03), as well as an increase in HDL-C ( p = 0.01) [ 96 ]. In a cross-sectional study, Brandao-Lima et al (2019) researched the impact of zinc, potassium, calcium, and Mg administration at different concentrations in 95 T2DM patients.…”
Section: Resultsmentioning
confidence: 99%
“…Overall, the vast majority of the analyzed RCTs reported no variations in HDL-C (n = 19), LDL-C (n = 16), TG (n = 17), TC (n = 14), TC/HDL-C (n = 4), VLDL (n = 2), or LDL-C/HDL-C (n = 1). However, some RCTs reported elevations of the HDL-C (n = 8), apoA1 (n = 1), or HDL-C/TG (n = 1), as well as reductions in LDL-C (n = 7), TC (n = 4), TG (n = 7), TC/HDL-C (n = 2), or VLDL (n = 3) in the participants exposed to the Mg intervention [ 13 , 14 , 18 , 35 , 36 , 38 , 41 , 42 , 43 , 53 , 80 , 82 , 83 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 95 , 96 , 98 , 99 , 105 , 109 , 111 , 113 , 123 ].…”
Section: Discussionmentioning
confidence: 99%
“…The decreased wound healing rate during the second and third four weeks of the study could be due to loss of power as a result of losing participants due to the complete wound closure. The strong positive effects of supplementation can be synergistic as a result of the appropriate intake of all the nutrients together since studies on supplementing with only one or two nutrients showed less positive effects [ 10 , 16 ]. While similar treatments have been effective in other types of chronic wound healing such as pressure ulcers [ 17 , 18 ], to our knowledge, there has not been any study conducted on the effects of complete supplementation along with nutrition education on wound healing in DFU patients.…”
Section: Discussionmentioning
confidence: 99%
“…Although the high prevalence of malnutrition and its negative effects on the healing of DFU is reported in several studies [ 4 , 5 , 6 , 7 ], to our knowledge there is no study looking at the effects of complete nutrition supplementation. Studies in this field have only examined the effects of supplementing diabetic patients with arginine, glutamine, beta-hydroxy-beta-methylbutyrate (HMB), magnesium, and vitamin E [ 8 , 9 , 10 ]. Furthermore, nutrition education has rarely been incorporated in DFU studies with supplementation.…”
Section: Introductionmentioning
confidence: 99%
“…Multiple studies have reported normal tissue radioprotection and antitumor activity with the use of both tocopherols and tocotrienols [171]. Although studies regarding the use of vitamin E in diabetic wound healing and other chronic wounds have been reported, preclinical and clinical studies on the effect of RT induced changes in wound healing are sparse [172,173]. However, the mechanism of vitamin E indicates that it could be used to treat wounds following RT, including those seen in the treatment of STS.…”
Section: Vitamin Ementioning
confidence: 99%