The effect of varicocele on seminal plasma and serum inhibin-B levels in adolescent and adult men

Başar, M. Murad; Kısa, Üçler; Tuglu, Devrim; Kaçmaz, Murat; Başar, Halil

doi:10.1007/s11255-009-9605-2

Cited by 11 publications

(8 citation statements)

References 26 publications

(36 reference statements)

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“…In the present study, we found a good response after varicocelectomy in the semen parameters in all patients with TMCs > 5 x10 6 and the greatest improvement was found in patients in Group I, who had the greatest preoperative TMCs. On the other hand, patients with severe oligozoospermia and azoospermia showed a bad response.…”

Section: Discussionsupporting

confidence: 66%

“…Therefore, according to these results, we could assume that an increase in the TMCs after varicocelectomy is an indicator of pregnancy rate improvement. After varicocelectomy TMCs increased more than 18x10 6 in all our patients provided the preoperative TMCs were more than 5x10 6 and the pregnancy rate reached 34.4%. These findings were comparable to previously reported results (24).…”

Section: Discussionmentioning

confidence: 53%

“…The greatest increase in motility rate after surgery was noted in group I (17.2 ± 1.4x10 6 ), while patients in group III had the lowest increase in motility rate (7.9 ± 1.8x10 6 ). The difference was statistically significant (p < 0.05).…”

Section: Resultsmentioning

confidence: 88%

“…These include hypoxia, stasis, testicular venous hypertension, elevated testicular temperature, increase in spermatic vein catecholamine, and increased oxidative stress (5). However, there have still been some undefined mechanisms of varicocele since some of the patients with varicocele have normal semen parameters (6). The most common indication for treatment of varicocele is still the male subfertility.…”

Section: Introductionmentioning

confidence: 99%

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Does the duration of infertility affect semen parameters and pregnancy rate after varicocelectomy?: a retrospective study

et al. 2011

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Objectives:The most common indication for treatment of varicocele is still male subfertility. The aim of this study was to explore the effect of infertility duration on semen parameters and spontaneous pregnancy rate after varicocelectomy. Materials and Methods:The medical records of 183 infertile patients with clinical varicocele were retrospectively reviewed. The patients were divided into three groups according to the duration of infertility (group I, 1-3 years, group II, 3-6 years and group III, > 6 years). Total sperm motility counts (TMCs) before and after varicocelectomy and spontaneous pregnancy rate among these groups were statistically compared. Results: The greatest changes, regarding preoperative and postoperative TMCs and spontaneous pregnancy rate were noticed between group I and III. Preoperative TMCs in group I and III was 15.2 ± 1.2, 7.8 ± 1.4, respectively (p < 0.05). Postoperative TMCs in group I and III was 33.7 ± 2.5, 25.2 ± 1.9, respectively (p < 0.05). An overall spontaneous pregnancy rate of 34.4% was achieved after inguinal varicocelectomy. The greatest spontaneous pregnancy rate was achieved in Group I (37.3%), and the lowest pregnancy rate in Group III (26.3%) (P < 0.05). Conclusions: Surgical varicocelectomy improves the total sperm motility counts especially in patients who have a TMCS more than 5 million and improves the spontaneous pregnancy rates. The improvement in the spontaneous pregnancy rates after varicocelectomy correlates negatively with the duration of infertility. Therefore, duration of infertility should be considered in treating a patient with a varicocele as a cause of infertility.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Does the duration of infertility affect semen parameters and pregnancy rate after varicocelectomy?: a retrospective study

et al. 2011

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“…Because levels of inhibin B have also been found to increase or decrease non-specifically in some adolescents and adults, with or without surgical correction, there is poor evidence to support its clinical application (De Sanctis et al, 2007;Di Bisceglie et al, 2007;Ozden et al, 2008;Basar et al, 2010). For example, one analysis of variance study, between 50 men with varicocoele, 50 adolescents with varicocoele and 50 fertile adults without scrotal pathology, found no correlation of serum and seminal plasma inhibin-B levels between groups (Basar et al, 2010).…”

Section: Predictors Of Testicular Injury/indicators Of Surgerymentioning

confidence: 99%

Adolescent varicocoele management controversies

2012

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SUMMARYVaricocoele is defined as excessive dilatation of the pampiniform venous plexus of the spermatic cord. Varicocoele frequently appears during early puberty and is recognized to be the most common surgically correctable cause of male infertility. However, the actual incidence in adolescents, pathophysiology and the association with male factor infertility all remain somewhat controversial. The most accurate diagnostic technique for identifying young men who will benefit from surgical treatment has yet to be established. Observations of testicular asymmetry and deteriorating semen quality helped establish current guidelines and recommendations for surgical treatment. Further studies, comparing observation with surgical intervention, are needed to refine the current indications for varicocoele repair in the adolescent male.

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Varikozele bei Jugendlichen

Czeloth

Kälble

Kliesch

2013

Urologe

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Testicular varicocele is present in 15 % of adolescent boys. The very impact of this pathology and who will be at risk of developing into infertility remains unclear. Research on the pathophysiology, results of surgical or radiological interventions and potential predictors for long-term impairment of spermatogenesis and thus fertility is still ongoing. Indications for treatment are mainly based on differences in testicular volumes as semen parameters are most often not available; however, whether testicular volume is a valuable prognostic parameter for later fertility remains questionable. Approximately 50 % of adolescent patients with varicocele experience spontaneous increase of testicular volume without any intervention.

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The effect of varicocele on seminal plasma and serum inhibin-B levels in adolescent and adult men

Abstract: While varicocele affects different mechanisms in the regulation of spermatogenesis in testes, serum and seminal plasma inhibin-B have not any role in decreased spermatogenesis in varicocele.

Cited by 11 publications

References 26 publications

Does the duration of infertility affect semen parameters and pregnancy rate after varicocelectomy?: a retrospective study

Does the duration of infertility affect semen parameters and pregnancy rate after varicocelectomy?: a retrospective study

Adolescent varicocoele management controversies

Varikozele bei Jugendlichen

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