1974
DOI: 10.1016/0002-9394(74)90474-7
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The Effect of Tobramycin on Rabbit Eyes

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Cited by 15 publications
(3 citation statements)
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“…Furthermore, netilmicin ophthalmic solution (NETTACIN eye drops 0.3%), is also formulated and available in some countries as a preservative-free solution, thus lacking the detrimental effects of preservatives on the ocular surface (16)(17)(18)(19)(20). However, netilmicin, as with all other aminoglycosides (33)(34)(35)(36), does not easily penetrate the corneal epithelial barrier because of its hydrophilic properties and, consequently, effective concentrations of the drugs cannot be attained in the anterior chamber by topical administration. For all these reasons, netilmicin may be considered as an "ideal" antibiotic for the treatment of external eye disease; however, its influence on epithelial proliferation and integrity is at present unknown.…”
Section: Discussionmentioning
confidence: 96%
“…Furthermore, netilmicin ophthalmic solution (NETTACIN eye drops 0.3%), is also formulated and available in some countries as a preservative-free solution, thus lacking the detrimental effects of preservatives on the ocular surface (16)(17)(18)(19)(20). However, netilmicin, as with all other aminoglycosides (33)(34)(35)(36), does not easily penetrate the corneal epithelial barrier because of its hydrophilic properties and, consequently, effective concentrations of the drugs cannot be attained in the anterior chamber by topical administration. For all these reasons, netilmicin may be considered as an "ideal" antibiotic for the treatment of external eye disease; however, its influence on epithelial proliferation and integrity is at present unknown.…”
Section: Discussionmentioning
confidence: 96%
“…Subconjunctival aminoglycosides and other antibiotics have been known to penetrate into aqueous or corneal tissuell5ll9,120 [134][135][136] and reported to have a clinically therapeutic effect in experimental bacterial keratitis. 101,103,106,107,112 However, the quantitative microbiologic effect of subconjunctival aminoglycosides has been unclear, and their relative efficacy and value have been questioned, compared with fortified topical regimens. 110,119'122,123 Also, their role as therapy adjunctives to an intensive topical regimen has been unclear.…”
Section: Subconjunctival Therapymentioning
confidence: 99%
“…aeruginosa (Purnell and McPherson, 1974), it rapidly penetrates the eye. And since it is now available as an injectable solution (Nebcin@*), we decided to test both its efficacy and its toxicity when used to treat Pseudomonas-infected rabbit eyes, and to compare these effects with those of gentamicin.…”
mentioning
confidence: 99%