The study sought to identify the conditions and factors that generate acute stress among the workers in the public service with particular emphasis on workers at A.M.E Zion Hospital in the Offinso North District and the extent to which it impacts on effective service delivery and performance. The in-depth semi-structured interviews were employed to obtain data. To this end, a case study methodology design was used. In all, 25 health workers were interviewed at the hospital facility, 5 at the Ante Natal Center, 6 at Reproductive child health clinic and 14 at Labour ward. Workers (nurses) were chosen for the study according to their convenience to the researcher. Qualitative data analysis was employed in order to make meaning out of the information collected. The study found out that the stress related factors among the workers were the workload, role ambiguity, role insufficiency, work family relations, adverse working conditions, career development, time pressure, individual factors. Organizational adjustment, changing global scene and working under two perceived supervisors. The physiological stress related effects also included the feeling of anxiousness, irritation and depression. Whiles being irritated, their working relations with both clients and colleagues begin to change negatively especially towards innocent clients; also, excessive sweating which is a sign of stress and fatigue makes the workers uncomfortable to continue working and subsequently loses interest to work and sometimes have trouble concentrating. These factors have affected the workers in several ways including reduced productivity, low employee morale to work and poor working relations. The proposed recommendations include electronic folder management system, an enhanced staff strength with proper motivation of the staff.