The Effect of the Antioxidant Drug “U-74389G” on Creatine Phosphokinase Levels during Ischemia Reperfusion Injury in Rats

Abstract

This experimental study examines the effect of the antioxidant drug "U-74389G" on rat model, particularly in an ischemia-reperfusion (IR) protocol. The effects of this molecule were biochemically studied using mean creatinine phosphokinase (CPK) levels in blood. Materials and Methods: Forty rats with a mean weight of 231.875 g were used in the study. CPK levels were measured at 60 min (groups A and C) and at 120 min of reperfusion (groups B and D); A and B were groups without U-74389G administration, but C and D were groups with U-74389G administration. Results: U-74389G administration significantly increased CPK levels by 35.34%+17.20% (p=0.0260). Reperfusion time nonsignificantly increased CPK levels by 13.17%+18.05% (p=0.4134). However, U-74389G administration and reperfusion time together non-significantly increased CPK levels by 18.52%+9.44% (p=0.0770). Conclusion: U-74389G administration significantly increased CPK levels for a short term; however, these levels could not be restored, and the restoration capacity increases along with reperfusion time.

The Acute Effect Of The Antioxidant Drug “U-74389g” On Platelet Distribution Width During Hypoxia Reoxygenation Injury In Rats

“…The U-74389G dose was 10 mg/Kg body mass of animals. The detailed anesthesiologic technique following prenarcosis, is described in related references [3][4][5]. Then the protocol of HR was executed.…”

“…This agent has been proved to prevent permeability alterations in brain endovascular cells monolayers [2]. A more generalized numeric evaluation of the U-74389G efficacy was tried to be outcome by a meta-analysis of 13 published seric variables, for the same experimental endpoints (Table 1) [3][4][5]). This study is accordant with a recent trend of testing many other similar antioxidant molecules [6].…”

The Effect of Erythropoietin on Total Protein Levels during Ischemia Reperfusion Injury in Rats

“…Perhaps, a longer study time or a higher Epo dose may reveal more significant results aligned with bibliography. This information must be into consideration upon laboratory investigation of neurologic diseases in case of being co-treated by Epo [21][22][23][24][25][26].…”

The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

“…The detailed anesthesiologic technique is described in related references. [15][16][17] Oxygen supply, electrocardiogram and acidometry were continuously provided during whole experiment performance. The protocol of HR was followed.…”