The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

et al. 2017

Ital J Med

Self Cite

This experimental study examined the effect of the antioxidant drug U-74389G, on a rat model and particularly in a renal ischemia-reperfusion protocol. The effects of that molecule were studied biochemically using blood mean urea levels. Forty rats of mean weight 231.875 g were used in the study. Urea levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted urea levels by 11.35%±2.73% (P=0.0001). Reperfusion time non-significantly increased the predicted urea levels by 2.26%±3.29% (P=0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted urea levels by 6.31%±1.70% (P=0.0005). U-74389G administration whether it interacted or not with reperfusion time had significant decreasing effect on the urea serum levels, reflecting a respective renal function augmentation.

Section: This Basic Experimental Research Was Licensed Bymentioning

confidence: 99%

The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats

Tsompos

et al. 2017

Ital J Med

Self Cite

“…7 days pre-experimental normal housing included ad libitum diet in laboratory. Prenarcosis of animals preceded of continuous intra-experimental general anesthesia [3][4][5][6], oxygen supply, electrocardiogram and acidometry. Post-experimental euthanasia did not permitted awakening and preservation of the animals.…”

Section: Animal Preparationmentioning

confidence: 99%

The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats

Tsompos¹,

et al. 2016

Acta Medica Bulgarica

Summary. This experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in a liver ischemia -reperfusion protocol. The effects of that molecule were studied biochemically using blood mean albumin levels. 40 rats of mean weight 231.875 g were used in the study. Albumin levels were measured at 60th min of reperfusion (groups A and C) and at 120th min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration signifi cantly decreased the predicted albumin levels by 3.63% ± 0.87% (p = 0.0001). Reperfusion time non-signifi cantly increased the predicted albumin levels by 0.72% ± 1.04% (p = 0.4103). However, U-74389G administration and reperfusion time together signifi cantly decreased the predicted albumin levels by 2.02% ± 0.54% (p = 0.0005). U-74389G administration whether it interacted or not with reperfusion time has signifi cant decreasing short -term effects on albumin levels. It seems that the antioxidant capacity is associated with albumin catabolism.

“…That care included normal 7 days pre-experimental housing in laboratory with ad libitum diet. Furthermore, it used preceded prenarcosis and non stop general anesthesia [1][2][3][4], electrocardiogram, acidometry and oxygen supply. Finally it did not permit post-experimental preservation of the rodents.…”

Section: Animal Preparationmentioning

confidence: 99%

The acute effect of erythropoietin on mean corpuscular volume levels during hypoxia-reoxygenation injury in rats

Tsompos¹,

et al. 2016

JCB

Abstract. OBJECTIVE:This experimental study examined the effect of erythropoietin (epo) in a rat model and particularly in a hypoxia-reoxygenation (HR) protocol. The effect of epo was studied hematologically using the blood mean corpuscular volume (MCV) levels. MATERIALS AND METHODS: 40 rats of mean weight 247.7±34.991 g were used in the study. MCV levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reoxygenation. Epo was administered only in groups C and D. RESULTS: Epo administration increased non-significantly the predicted MCV levels by 0.56% ± 0.66% (p = 0.3549). The reperfusion time decreased non-significantly the predicted MCV levels by 0.55% ± 0.65% (p = 0.3721). Epo administration and reperfusion time together did also not induce an increase of the MCV levels (0.30% ± 0.39%; p = 0.4430). CONCLUSIONS: Epo administration, reperfusion time and their interaction had no short -term effect on MCV within the time of 2 hours.