The Acute Effect Of The Antioxidant Drug “U-74389g” On Platelet Distribution Width During Hypoxia Reoxygenation Injury In Rats

Abstract

Background: Platelet activation causes morphologic changes of platelets, including both the spherical shape and pseudopodia formation increasing platelet distribution width (PDW), ascribed to platelet anisocytosis. Furthermore, coagulation is activated in vaso-occlusive situations, increasing PDW. Early diagnosis of progressive activation of coagulation or any factor declining PDW levels, can prevent these thromboembolic diseases successfully. The probable beneficial effect of the molecule "U-74389" was studied hematologically using blood mean platelet distribution width PDW) levels. Methods: 40 rats of mean weight 231.875g were used in the study. PDW levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D) with administration of the drug U-74389G in groups C and D. Results: U-74389G administration kept significantly increased the PDW levels by 1.79%±0.76% (p=0.0314). Reoxygenation time non significantly declined the PDW levels by 0.745%±0.81% (p=0.3280). However, U-74389G administration and reoxygenation time together kept significantly increased the PDW levels by 0.96%±0.46% (p=0.0396). Conclusion: U-74389G administration whether it interacted or not with reoxygenation time borderline declines from significant to non significant the PDW levels, within short-time study period of 2 hours. This finding has huge clinical interest in coagulopathy prevention or reversion.

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