The effect of synthesis parameters on morphology and diameter of electrospun hydroxyapatite nanofibers

Faridi‐Majidi, Raheleh; Nezafati, Nader; Pazouki, Mohammad; Hesaraki, Saeed

doi:10.1007/s41779-017-0028-8

Cited by 17 publications

(7 citation statements)

References 48 publications

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“…These nanofibers act as nuclei for the crystallization process 33 . This is confirmed by high surface area nanometric and submicrometric fibers used in place of commonly agglomerated powders 12,[35][36][37][38] .…”

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confidence: 61%

Calcium phosphate submicrometric fibers produced by solution blow spinning

et al. 2019

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The purpose of this work was to produce submicrometric hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) biphasic fibers by means of solution blow spinning (SBS). This method was chosen due to its lower cost and higher production rate than those of electrospinning, which is normally employed in ceramic fiber production. The fibers thus obtained were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The in vitro bioactivity and cytotoxicity of the fibers were also investigated. The XRD patterns indicated the formation of biphasic HA/βTCP fibers. SEM analysis revealed an interconnected cylindrical morphology with the presence of beads. Fiber diameters in the submicrometric range varied from 374 to 451 nm. TGA results indicated that organic losses occurred solely below 600ºC. All the fibers were non-cytotoxic, presenting an inhibitory concentration (IC) of > IC50. All the samples successfully formed acicular apatite layers when immersed in SBF, indicating a high potential for in vivo bone bioactivity.

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confidence: 61%

Calcium phosphate submicrometric fibers produced by solution blow spinning

et al. 2019

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“…Electrospun n‐HAs were prepared according to our recent work . In brief, Ca–P sol was prepared by mixing certain solutions of calcium nitrate tetrahydrate (Ca(NO 3 ) 2 ·4H 2 O, Germany, Merck, 102120) and triethyl phosphate (C 6 H 15 O 4 P, Germany, Merck, 821141) and subsequently stirring them for 24 h. Polyvinylpyrrolidone (PVP) solution with a concentration of 15% (w/v) was added to the sol with a volume ratio Ca–P sol to PVP solution of 1:3.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and characterization of a novel freeze‐dried silanated chitosan bone tissue engineering scaffold reinforced with electrospun hydroxyapatite nanofiber

Nezafati

Faridi‐Majidi

Pazouki

et al. 2019

Polymer International

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Novel chitosan scaffolds containing different weight ratios of electrospun hydroxyapatite nanofibers (n-HAs) were fabricated. The fibers possessed diameters in the range 110-170 nm. A fixed concentration of glycidyloxypropyl-trimethoxysilane (GPTMS) as a crosslinking agent was added to the chitosan solution (CG). The porosity percentage was increased when GPTMS and n-HAs were added to the chitosan structure. The presence of GPTMS in the chitosan structure caused a decrease in the average pore size. The pores were more irregular in shape than pure chitosan and CG scaffolds when n-HAs were added. A uniform distribution of n-HAs was seen for a chitosan-GPTMS hybrid scaffold containing 25 wt% n-HAs (CGH25) using energy dispersive X-ray spectroscopy and mapping. The best values of compressive strength and elastic modulus were achieved for CGH25. The swelling ratio was decreased on adding GPTMS to the chitosan scaffold. Different morphologies of hydroxyapatite deposits on the surface of CG and CGH25 (string-like versus needle-like precipitates) were observed after 14 days of soaking in simulated body fluid. For CGH25, the viability of MG-63 osteoblastic cells improved with respect to CG for up to 72 h of cell culture. These results reveal the potential of the chitosan-CGH25 scaffold for use in bone tissue engineering.

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“…This is how a non-woven and randomly oriented fibrous polymer network with different fiber diameters from 100 nm to several micrometers is obtained, depending on the specific polymer solution and electrospinning parameters. This method cannot control the size of the pores and their location concerning the internal channels [6,19,20].…”

Section: Literature Reviewmentioning

confidence: 99%

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Chernobrovchenko¹,

Dyadyura²,

Balynskyi³

et al. 2021

JES

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The implantation of bone substitutes depends on the material’s osteoconductive potential and the structure’s porosity Porosity is a characteristic feature of most materials. The porosity of materials has a strong influence on some of their properties, both structural and functional. An essential requirement for bone scaffolds is porosity, which guides cells into their physical structure and supports vascularization. The macroporosity should be large enough and interdependent for bone ingrowth to occur throughout the entire volume of the implant. The pore size for cell colonization in bioceramics is approximately 100 μm. Pores larger than this value promote bone growth through the material. This pore size allows the flow of growth factors and cell adhesion and proliferation, allowing the formation of new bone and developing the capillary system associated with the ceramic implant. Porosity also affects the rate of resorption of ceramics: the larger the number of micropores, the higher the dissolution rate. The investigated properties were elastic moduli, ultimate strength, compressive strength, and average apparent density. The results obtained in this work are consistent with previous studies, proving the positive role of microporosity in osseointegration and bone formation.

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The effect of synthesis parameters on morphology and diameter of electrospun hydroxyapatite nanofibers

Cited by 17 publications

References 48 publications

Calcium phosphate submicrometric fibers produced by solution blow spinning

Calcium phosphate submicrometric fibers produced by solution blow spinning

Synthesis and characterization of a novel freeze‐dried silanated chitosan bone tissue engineering scaffold reinforced with electrospun hydroxyapatite nanofiber

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

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