The effect of surface modification of TiMg composite on the in-vitro degradation response, cell survival, adhesion, and proliferation

Ibrahim, Ahmed Mohamed Hassan; Takáčová, Martina; Jelenska, Lenka; Csáderová, Lucia; Balog, Martin; Kopáček, Juraj; Švastová, Eliška; Krížik, Peter

doi:10.1016/j.msec.2021.112259

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…Rough implant surfaces are more prone to osteosynthesis than smooth implant surfaces because rough implant surfaces exhibit higher osteogenic activity, such as cell adhesion, cell proliferation, and calcium nodule deposition . Surface roughness with an Ra value between 20 nm and 10 μm has been demonstrated in studies to substantially affect the biocompatibility of implant materials and the initial adherence of cells. , Furthermore, after chitosan modification, the contact angle of PEEK-CS was decreased. With a smaller contact angle, PEEK-CS is more hydrophilic than bare PEEK.…”

Section: Resultsmentioning

confidence: 99%

“…43 Surface roughness with an Ra value between 20 nm and 10 μm has been demonstrated in studies to substantially affect the biocompatibility of implant materials and the initial adherence of cells. 44,45 Furthermore, after chitosan modification, the contact angle of PEEK-CS was decreased. With a smaller contact angle, PEEK-CS is more hydrophilic than bare PEEK.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Dual-Functional Polyetheretherketone Surface with an Enhanced Osteogenic Capability and an Antibacterial Adhesion Property In Vitro by Chitosan Modification

et al. 2022

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A chitosan layer was covalently bonded to a polyetheretherketone (PEEK) surface using a simple facile selfassembly method to address inadequate biological activity and infection around the implant. The surface characterization, layer degradation, biological activity, and antibacterial adhesion properties of chitosan-modified PEEK (PEEK-CS) were studied. Through chitosan grafting, the surface morphology changed, the surface roughness increased, and the contact angle decreased significantly. PEEK-CS boosted cell adhesion, proliferation, increased alkaline phosphate activity, extracellular matrix mineralization, and expression of osteogenic genes. PEEK-CS demonstrated less adhesion to Porphyromonas gingivalis as well as less bacterial adhesion to P. gingivalis and Streptococcus mutans. According to our findings, chitosan modification significantly improved the osteogenic ability and antibacterial adhesion of PEEK in vitro.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Dual-Functional Polyetheretherketone Surface with an Enhanced Osteogenic Capability and an Antibacterial Adhesion Property In Vitro by Chitosan Modification

et al. 2022

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“… 53 , 54 Substrate morphology significantly influences cell adhesion to the substrate and intercellular interactions, thereby regulating cell adhesion and arrangement behaviors. 55 First, nanographene is intrinsically nonflat and has nanoscale ripples and folds on the surface. The particular surface morphology of nanographene may be responsible for the adhesion of cells.…”

Section: Discussionmentioning

confidence: 99%

Selective Polyetheretherketone Implants Combined with Graphene Cause Definitive Cell Adhesion and Osteogenic Differentiation

Su¹,

Zhang²,

Tan³

et al. 2022

IJN

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Introduction Polyetheretherketone (PEEK) has good biosafety and chemical stability for bone repair. However, PEEK is biologically inert and cannot promote bone apposition. This study investigated whether graphene-modified PEEK (G-PEEK) could improve cell adhesion and osteogenic differentiation. Methods G-PEEK was prepared by melted blending and was characterized. In vitro, the biocompatibility of G-PPEK and the ability to promote cell adhesion and osteogenic differentiation in rabbit bone marrow mesenchymal stem cells (rBMSCs) were examined using live and dead cell double staining, the cell counting kit-8 (CCK-8) assay, immunofluorescence and quantitative real-time PCR (qRT‒PCR). An in vivo rabbit extra-articular graft-to-bone healing model was established. At 4 and 12 weeks after surgery, CT analysis and histological evaluation were performed. Results In vitro, G-PEEK significantly improved the adhesion and proliferation of rBMSCs, with good biocompatibility. In vivo, G-PEEK promoted new bone formation at the site of the bone defect. Conclusion G-PEEK showed excellent osteogenesis performance, which promises new applications in implant materials.

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“…The modified warm compaction method for producing of Ti and Ti composites was developed by Balog et al for the dental [20,33,34] and by Sugar et al for biomedical applications [35][36][37]. The Ti powder/ Ti composites were pre-compacted by cold isostatic pressing (CIP) at 200 MPa.…”

Section: Methodsmentioning

confidence: 99%

Surface treatment of Ti and Ti composites using concentrating solar power and laser

Kováčik

Emmer²,

Rodríguez³

et al. 2023

European Mechanical Science

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Titanium and its composites are widely used in implants of bones and teeth. Besides mechanical properties also surface characteristics are very important in these biomaterials. Very important are properties such as surface topography, roughness, chemistry, and surface energy, wettability, and Ti oxides or Ti nitride layers thickness. The concentrated solar power was used successfully to nitride Ti Grade 2 and powder metallurgical Ti prepared from hydrogenated dehydrogenated Ti powder. The nitriding experiments were performed under nitrogen atmosphere at different temperatures and time in SF40 (40kW horizontal solar furnace) at PSA, Spain. Concentrated solar energy has been shown to be an economical alternative to conventional gas nitriding techniques in electric furnaces, CVD, PVD, plasma nitriding, or laser treatments. It has been observed that the solar process represents a significant reduction of the heating time to several minutes (up to 5 minutes at temperature range 500-1000 °C), a clean and non-polluting high-temperature process. The formation of continuous and homogeneous surface layers of TiN, Ti2N and their mixture according to the nitriding temperature was investigated using X-ray diffraction and electron microscopy. Laser surface treatment is of great significance in modifying surface morphology and surface and near-surface region microstructures. Effects of lase treatment parameters on machined surface morphology, surface roughness and chemistry are analyzed in this study and discussed from the point of view of application in dental implantology. The current advances of our research group in application of laser-treated powder metallurgy prepared Ti-based materials are analyzed and discussed.

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The effect of surface modification of TiMg composite on the in-vitro degradation response, cell survival, adhesion, and proliferation

Cited by 9 publications

References 34 publications

Dual-Functional Polyetheretherketone Surface with an Enhanced Osteogenic Capability and an Antibacterial Adhesion Property In Vitro by Chitosan Modification

Dual-Functional Polyetheretherketone Surface with an Enhanced Osteogenic Capability and an Antibacterial Adhesion Property In Vitro by Chitosan Modification

Selective Polyetheretherketone Implants Combined with Graphene Cause Definitive Cell Adhesion and Osteogenic Differentiation

Surface treatment of Ti and Ti composites using concentrating solar power and laser

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