The effect of sodium salicylate on bile secretion in the dog.

Abstract

SUMMARY1. The i.v. injection of sodium salicylate (100 mg/kg) in the dog caused a rapid and maintained choleresis of the order of 300-600% of control levels.2. The total amount of salicylate excreted in bile was only 1-2 % of that injected.3. The secretion of bile salt into bile was not increased by salicylate. 4. The choleresis caused by salicylate was associated with a decrease in the concentrations of sodium and of bile salt in bile, and with an increase in the concentration of chloride; the biliary concentration of bicarbonate was either temporarily increased or unchanged.5. The choleresis could not be inhibited by the intra-portal injection of ouabain (0.1 mg/kg).6. The secretion of bromsulphthalein into bile was not potentiated by the choleresis.7. The choleretic efficiency of sodium taurocholate was not increased in the presence of salicylate.8. The injection of acetazolamide (20 mg/kg), in the presence of a salicylate choleresis, caused an increase in the osmolality of bile and an increase in biliary sodium concentration, such that the composition of bile more nearly approached that of plasma.9. The possible mechanisms underlying the choleretic effect of sodium salicylate are discussed.

Effect of Lysine Acetylsalicylate on Biliary Lipid Secretion in Dogs

“…A choleretic effect of sodium salicylate has been reported by Rutishauser & Stone (1973). In the present work it has been shown that a marked increase in bile flow can also be produced by acetylsalicylate, when administered intravenously as the water-soluble lysine derivative.…”

Effect of sodium salicylate, sodium oxalate, and sodium chloride on the micellization and adsorption of sodium deoxycholate in aqueous solutions

“…They [4] also reported first and second cmc values of mixtures of sodium dodecyl sulfate with various bile salts as these mixtures formed mixed micelles. The secretion of bile by the liver into the gallbladder is called choleresis and salicylate ion is known to have a choleretic effect in rats, dogs, and humans [5][6][7][8]. Choleretic effect refers to increasing the rate of bile flow and the mechanism by which salicylate exhibits this effect is not clearly known.…”

“…Choleretic effect refers to increasing the rate of bile flow and the mechanism by which salicylate exhibits this effect is not clearly known. It is reported [5] that the influence of salicylate anion on the bile salt micelles might be one of the reasons for its choleretic effect. Further, there are reports of bile salts affecting the colonic absorption of oxalate and inhibition of calcium oxalate precipitation by bile salts [9,10].…”

Oral acetylsalicylic acid induces biliary cholesterol secretion in the rat

“…Infusion of sodium salicylate (SA) or lysine acetylsalicylate (ASA) increased bile flow in dogs and monkeys (17)(18)(19). Bile salt secretion did not change in dogs given the salicylates (17,19), but lecithin and cholesterol secretion fell markedly in those given lysine ASA (19). Bile lipid secretion was not altered in monkeys infused with sodium SA (18).…”