The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis

Kiss, Lóránd; Für, Gabriella; Mátrai, Péter; Hegyi, Péter; Ivány, Emese; Cazacu, Irina M.; Szabó, Imre; Habon, Tamás; Alizadeh, Hussain; Gyöngyi, Zoltán; Vigh, Éva; Erős, Adrienn; Ottóffy, Máté; Czakó, László; Rakonczay, Zoltán

doi:10.1038/s41598-018-32337-x

Cited by 64 publications

(61 citation statements)

References 56 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An elevated cholesterol level at admission was not associated with increased mortality in our cohort, which is in accord with the fi ndings of some recent metaanalysis regarding triglycerides levels 18,19 .…”

Section: Methodssupporting

confidence: 93%

Hypercholesterolemia, as a Predictor Factor of Severe Acute Pancreatitis

Socea¹,

Bolocan²,

Bratu³

et al. 2018

Rev. Med. Mod.

View full text Add to dashboard Cite

Dyslipidemia constitutes a well-known factor that can lead to acute pancreatitis. Hypertrigliceridemia and hypercholesterolemia are part of dyslipidemia. In a prospecitve study, we analyzed the role of hypercholesterolemia in triggering episodes of acute pancreatitis and the capacity of cholesterol blood level to predict the severity and the evolution of acute pancreatitis. In our prospective study, a preexistent cholesterol blood level above 240 mg/dl proved to be a trigger for pancreatitis and an increasing cholesterol level in evolution predicts a pancreatitis with organ failure (moderately-severe or severe).

show abstract

Section: Methodssupporting

confidence: 93%

Hypercholesterolemia, as a Predictor Factor of Severe Acute Pancreatitis

Socea¹,

Bolocan²,

Bratu³

et al. 2018

Rev. Med. Mod.

View full text Add to dashboard Cite

show abstract

“…Obesity is another risk factor in AP; obese patients have a three-fold increased risk of mortality compared to those with a BMI < 30 [ 15 ]. High triglyceride level is also a risk factor, serum triglyceride level higher than 5.6 mmol/L significantly increases the mortality rate (OR = 2.75, 95% CI = 1.28–5.92, p < 0.01) [ 16 ]. An experimental study in rat AP model demonstrated that the presence of FLD increased pro-inflammatory cytokine production, which may worsen the course of the disease [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis

Váncsa

Németh

Hegyi

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accordance with PRISMA guidelines, we performed a systematic search in seven medical databases for cohort studies that compared the outcomes of AP for the presence of FLD or NAFLD, and we calculated pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). We included 13 articles in our meta-analysis. AP patients with FLD were more likely to die (5.09% vs 1.89%, OR = 3.56, CI = 1.75–7.22), develop severe AP (16.33% vs 7.87%, OR = 2.67, CI = 2.01–3.56), necrotizing pancreatitis (34.83% vs 15.75%, OR = 3.08, CI = 2.44–3.90) and had longer in-hospital stay (10.8 vs 9.2 days, WMD = 1.46, OR = 0.54–2.39). Patients with NAFLD were more likely to have severe AP and longer hospital stay. Both FLD and NAFLD proved to be independent risk factors of a more severe disease course (OR = 3.68, CI = 2.16–6.29 and OR = 3.39, CI = 1.52–7.56 for moderate/ severe vs. mild AP, respectively). FLD and NAFLD worsen the outcomes of AP, which suggests that incorporating FLD or NAFLD into prognostic scoring systems of AP outcomes might improve the prediction of severity and contribute to a more individualized patient care.

show abstract

“…The most common cause of APP is gallstones, followed by alcohol abuse, hypertriglyceridemia, and unknown causes [3]. Non-gallstone pancreatitis is thought to be related to more complications and a poorer prognosis, such as hypertriglyceridemia-induced AP (HTG-AP) [4].…”

Section: Introductionmentioning

confidence: 99%

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Zeng

Cai

Chen

et al. 2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background Hypertriglyceridemia-induced acute pancreatitis during pregnancy (HTG-APP) is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-APP remains unclear. Methods In the retrospective study, we collected 45 patients with HTG-APP as the HTG-APP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results MPV were significantly higher in the HTG-APP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Logistic regression analyses revealed that MPV was significantly associated with SAP (odds ratio = 2.077, 95% confdence interval, 1.038–4.154; P = 0.039). Conclusions These results may indicate an important role of mean platelet volume in evaluating the severity of HTG-APP.

show abstract

The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis

Cited by 64 publications

References 56 publications

Hypercholesterolemia, as a Predictor Factor of Severe Acute Pancreatitis

Hypercholesterolemia, as a Predictor Factor of Severe Acute Pancreatitis

Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Contact Info

Product

Resources

About