Hypercholesterolemia, as a Predictor Factor of Severe Acute Pancreatitis

Abstract

Dyslipidemia constitutes a well-known factor that can lead to acute pancreatitis. Hypertrigliceridemia and hypercholesterolemia are part of dyslipidemia. In a prospecitve study, we analyzed the role of hypercholesterolemia in triggering episodes of acute pancreatitis and the capacity of cholesterol blood level to predict the severity and the evolution of acute pancreatitis. In our prospective study, a preexistent cholesterol blood level above 240 mg/dl proved to be a trigger for pancreatitis and an increasing cholesterol level in evolution predicts a pancreatitis with organ failure (moderately-severe or severe).

Double-guidewire technique for selective biliary cannulation does not increase the rate of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with naïve papilla

“…Several studies also reported relationship between a high serum low-density lipoprotein cholesterol (LDL-C) level and severe acute pancreatitis. [24][25][26] One possible explanation is that oxidative stress resulting from chronic elevation of the serum LDL-C level plays an important role in pancreatic inflammation. 24,26 Thus, it may be possible that hyperlipidemia aggravates pancreatic inflammation induced by cannulation injury.…”