The effect of semipurified diets containing different proportions of either casein or soybean protein on the concentration of cholesterol in whole serum, serum lipoproteins and liver in male and female rats

Terpstra, A.H.M.; Tintelen, G. van; West, C.E.

doi:10.1016/0021-9150(82)90129-0

Cited by 71 publications

(27 citation statements)

References 34 publications

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“…Furthermore, the effect of amidated pectin was less pronounced in male rats; only a moderate reduction in serum cholesterol was observed in treated animals [8]. The data of Terpstra et al [10] are consistent with these findings. In the female rats, the feeding of casein-containing diets resulted in significantly higher levels of serum cholesterol than from soybean-protein-containing diets.…”

Section: Discussionmentioning

confidence: 61%

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Comparative effect of amidated pectin and psyllium on cholesterol homeostasis in rats

et al. 2010

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Abstract:The effects of amidated pectin and psyllium on serum, hepatic and faecal cholesterol concentration were compared in female rats fed diets supplemented with palm fat and cholesterol at 50 and 10 g/kg, respectively. Control rats were fed a diet supplemented with cellulose at 60 g/kg. In treated rats, cellulose was replaced with either amidated pectin or psyllium. Amidated pectin and psyllium intake significantly decreased serum cholesterol from 3.41 µmol/ml (control) to 1.68 and 2.04 µmol/ml, respectively, and hepatic cholesterol from 31.9 µmol/g (control) to 7.2 and 9.0 µmol/g, respectively. Histology with lipid-staining Sudan Black B revealed that liver tissue from control rats was infiltrated with lipids, but staining was absent in livers of treated rats. No hepatic pathophysiology was apparent in treated rats. Amidated pectin and psyllium intake significantly increased faecal fat content. Faecal cholesterol content was significantly increased in rats that were fed amidated pectin, and non-significantly increased in rats that were fed psyllium. Body weight and food intake did not differ among treatment groups. In conclusion, amidated pectin, a novel sequestrant of sterols, demonstrated a similar effect on rat serum and hepatic cholesterol concentration to psyllium, which is a well-established hypocholesterolaemic agent.© Versita Sp. z o.o.

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Section: Discussionmentioning

confidence: 61%

“…Rats have the ability to convert excess dietary cholesterol to bile acids and, as such, are rather resistant to hypercholesterolaemic diets [9]. Female rats were chosen because female rats are more susceptible to dietary cholesterol [10].…”

Section: Introductionmentioning

confidence: 99%

Comparative effect of amidated pectin and psyllium on cholesterol homeostasis in rats

et al. 2010

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“…In the present communication we describe the effects of hypercholesterolaemic diets, generally diets enriched with cholesterol, on the density profile and the cholesterol concentration of serum lipoproteins in various experimental animals and man. Parts of this work have been published previously as aspects of studies on the effects of dietary proteins on serum cholesterol (Scholz et al, 1982;Beynen et al, 1983b;Mol et al, 1982;Terpstra et al, 1982cTerpstra et al, , 1983b.…”

Section: Methodsmentioning

confidence: 99%

“…Their age at the beginning of the experiment was 40 days. The male lean Zucker rats were fed a commercial diet with or without 1.2'~,,, (w/w) cholesterol (Terpstra et al, 1982c). One group of the genetically obese Zucker rats was fed a cholesterol-free commercial diet, whereas the other group was provided with a semipurified diet containing 50% (w/w) casein and 1.2°~, cholesterol (Terpstra et al, 1983c).…”

Section: £\Vperimenl With Ratsmentioning

confidence: 99%

Density profile and cholesterol concentration of serum lipoproteins in experimental animals and human subjects on hypercholesterolaemic diets

Terpstra

Beynen

1984

Comparative Biochemistry and Physiology Part B: Comparative Bio

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Abstract--l. The density profile of Sudan black stained serum lipoproteins was studied in human subjects and various animal species on diets supplemented with cholesterol.2. In the animals studied (rabbits, calves, mice, chickens, rats and guinea-pigs), the feeding of cholesterol resulted in an elevation of serum cholesterol levels together with marked changes in the density profile and the cholesterol concentration of the serum lipoproteins. Large differences between animal species in their response to dietary cholesterol were found.3. In a human subject, an increased concentration of serum cholesterol due to the consumption of a diet supplemented with six egg yolks per day was reflected in an elevated level of LDL cholesterol, while changes in the density profile of stained serum lipoproteins were not observed.4. In subjects with familial type IlI and type IV hyperlipoproteinaemia, marked differences in the density profile of lipoproteins were found when compared with that of normolipoproteinaemic subjects.5. The density profile of stained iipoproteins in the type Ill patients was remarkably similar to that in cholesterol-fed chickens and lean Zucker rats.

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“…However, it has been shown that feeding female rats a casein-containing diet resulted in significantly higher levels of serum cholesterol than feeding them a soybean-protein-containing diet. No such differences were observed in male rats [12]. Similarly, in experiments by Radzki et al [6], hypercholesterolaemia induction was easier in female rats.…”

Section: Introductionmentioning

confidence: 63%

Gender-based differences in the effect of dietary cholesterol in rats

et al. 2012

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Male and female rats were fed diets supplemented with cholesterol and palm fat at 10 and 50 g/kg, respectively; serum, hepatic tissue and faeces were analysed. Cholesterol supplementation significantly increased serum and hepatic cholesterol both in male and female rats. Male and female rats fed the cholesterol-containing diet differed significantly in serum cholesterol concentration (2.48 µmol/mL vs 2.92 µmol/mL), concentration of serum triacylglycerols, but not in hepatic cholesterol concentration. The serum and hepatic cholesterol concentrations correlated non-significantly in male rats (r=0.491; P=0.063) and significantly in female rats (r=0.818; P<0.001). Cholesterol supplementation non-significantly decreased relative expression of the hepatic LDL receptor gene and significantly increased relative expression of the hepatic cholesterol 7α-hydroxylase gene in rats of both genders. The faeces of control rats contained similar amounts of cholesterol and bile acids. Cholesterol supplementation increased cholesterol concentration 10 times in the faeces of male rats and 12 times in faeces of female rats. The corresponding increases of bile acid concentration were much lower (83% in male rats and 108% in female rats). It can be concluded that the effects of cholesterol supplementation were more pronounced in female than in male rats.

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The effect of semipurified diets containing different proportions of either casein or soybean protein on the concentration of cholesterol in whole serum, serum lipoproteins and liver in male and female rats

Cited by 71 publications

References 34 publications

Comparative effect of amidated pectin and psyllium on cholesterol homeostasis in rats

Comparative effect of amidated pectin and psyllium on cholesterol homeostasis in rats

Density profile and cholesterol concentration of serum lipoproteins in experimental animals and human subjects on hypercholesterolaemic diets

Gender-based differences in the effect of dietary cholesterol in rats

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