The effect of rutin on ovarian ischemia-reperfusion injury in a rat model

Naykı, Cenk; Naykı, Ümit; Çimen, Ferda Keskin; Külhan, Mehmet; Yapça, Ömer Erkan; Kurt, Nezahat; Ozbek, Aslı Bilgin

doi:10.1080/09513590.2018.1450378

Cited by 42 publications

(41 citation statements)

References 39 publications

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“…Histopathological signs of hemorrhage, dilated congested blood vessels, PMNL infi ltration, and degenerated follicles in the ovarian tissue of the IRG group were also observed in this study. Same histopathological changes in rat ovaries related to I/R injury were shown in previous studies (10,37,38). Lutein also ameliorated these histopathological changes in the ovaries of the rats from LIRG group in this study and when compared to the IRG group, we observed normal appearance except for dilated congested blood vessels.…”

Section: Discussionsupporting

confidence: 87%

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The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

Turkler¹,

Kulhan²,

Ata³

et al. 2018

BLL

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OBJECTIVES: The aim of our study is to investigate biochemical and histopathological effects of lutein on the ovarian ischemia-reperfusion (I/R) injury in rats. BACKGROUND: Reactive oxygen species and cytokines have a very important role in the pathogenesis of I/R injury. Lutein and its derivatives may show an anti-infl ammatory effect in relation to the decrease in infl ammatory cytokines and increase in antioxidant enzymes. METHODS: Wistar albino female rats were randomly divided into three groups before surgery as follows: I/R group (IRG; n = 6), 1 mg/kg lutein + I/R group (LIRG; n = 6), and a healthy control group scheduled for a sham operation (SG; n = 6). The condition of ovarian ischemia was created by vascular clips. After two hours, the ovary was reperfused. Then, cyclooxygenase-1, cyclooxygenase-2, malondialdehyde and total glutathione levels were examined in ovary tissues of rats. RESULTS: As the results of our study demonstrated, in ovarian tissues of animals after I/R, there was an increase in the levels of malondialdehyde and cyclooxygenase-2, while total glutathione and cyclooxygenase-1 were decreased. At the same time, it has been observed however that these ratios are reversed in the LIRG group (p < 0.05). CONCLUSION: Lutein ameliorates the I/R-induced ovarian injury in rats by its antioxidative and anti-infl ammatory activities (Fig. 2, Ref. 39). Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 87%

“…The purpose of COX-1 is to protect the normal cell activity and cytoprotective activity in tissues. On the other hand, COX-2 rapidly increases in pathological conditions and induces the synthesis of proinfl ammatory PGs (10).…”

Section: Introductionmentioning

confidence: 99%

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

Turkler¹,

Kulhan²,

Ata³

et al. 2018

BLL

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“…The twisting or torsion of the ovary is a relatively common gynecological emergency especially in 1st three decades of life, which denotes the bending of the ovary and fallopian tube around the broad ligament . Clinical presentation is sometimes confounded by non‐specific symptoms such as abdominal pain, nausea and vomiting that leads to late or missed diagnosis .…”

Section: Introductionmentioning

confidence: 99%

Adalimumab mitigates ovarian ischemia–reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation

Beyazıt

Bűyűk

Türkön

et al. 2018

J of Obstet and Gynaecol

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Aim: Ovarian torsion is a rare but an important reason of acute lower abdominal pain in women and associated with serious morbidity and mortality, if not treated promptly. The aim of this study was to evaluate the effects of an antitumor necrosis factor-α antibody on ovarian torsion in a rat model of ischemiareperfusion (I/R) injury. Methods: Forty female Wistar Albino rats were used in the present study. The rats were randomly divided into four groups: group I (sham), group II (I/R), group III (I/R + isotonic saline) and group IV (I/R + adalimumab). The I/R model was induced by torsion of both ovaries. Immunohistochemical staining for interleukin-1β (IL-1β), nuclear factor-κB (NF-κB), and inducible nitric oxide synthase was performed. Tissue and serum oxidative stress markers in conjunction with apoptotic index (AI) with the terminal deoxynucleotidyl transferase dUTP nick end labeling method were also calculated. Results: Tissue total oxidant status, oxidative stress index and nitric oxide values were significantly decreased, and tissue total antioxidant status was found to be increased in group IV. Inflammation, vascular congestion and hemorrhagia were significantly lower in adalimumab-treated group. Serum oxidative stress markers and tissue malondialdehyde levels did not differ in study groups. The AI was significantly increased in groups 2 and 3. Adalimumab treatment significantly decreased the AI. Conclusion: Adalimumab therapy in rats attenuated I/R induced ovarian injury, possibly suppressing inflammation, inhibiting oxidative stress, and altering apoptotic pathways.

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“…It was reported that rutin provides a protective effect with an antioxidant activity in different organ tissues. In addition, the protective effect of rutin on tissues has been associated with the inhibition of TNF-a and IL-1b production [39]. It has been noted that rutin prevents MDA, MPO, TNF-a and IL-1b levels to increase in blood serum by cisplatin and tGSH level to decrease and preserves the tissue from oxidative and proinflammatory damage [30].…”

Section: Il-1b and Tnf-a Levels In Bladder Tissuementioning

confidence: 99%

Effect of rutin on oxidative and proinflammatory damage induced by cisplatin in blood serum, ureter, bladder and urethra in rats

Hirik

Bozkurt

Keskin

et al. 2020

Biotechnology & Biotechnological Equipment

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Rutin (Vitamin P1) is an antioxidant and anti-inflammatory flavonoid. This study examined the effect of rutin on the potential of cisplatin to cause oxidative and proinflammatory damage in blood serum, ureter, bladder and urethra in rats. Animals were divided into four groups: (i) healthy (HG), (ii) 50 mg/kg of rutin þ 5 mg/kg of cisplatin (C þ R50), (iii) 100 mg/kg of rutin þ 5 mg/kg of cisplatin (C þ R100) and (iv) only cisplatin (CG). Rutin and distilled water were applied once a day for eight days. Cisplatin was injected intraperitoneally at a dose of 5 mg/kg for eight days, once every two days. Finally, animals were sacrificed by high-dose anesthesia after blood samples were taken. Ureter, bladder and urethra tissues were removed and malondialdehyde (MDA), myeloperoxidase (MPO), total glutathione (tGSH), superoxide dismutase (SOD) interleukin beta (IL-1b) and tumor necrosis factor alpha (TNF-a) levels were measured. The results showed that the levels of MDA, MPO, IL-1b and TNF-a in the blood serum of the CG group increased significantly (p < 0.0001) and the tGSH and SOD levels decreased compared to the HG. Rutin administration reversed the effect as seen in C þ R50 and C þ R100 groups. However, there was no statistically significant difference in the levels of MDA, MPO, tGSH, SOD, IL-1b and TNF-a in ureter, bladder and urethra tissue (p > 0.05).This suggests that cisplatin produces oxidative stress in the blood serum but not in the ureter, bladder and urethra tissues. It was observed that rutin prevented the cisplatin-related oxidative and proinflammatory damage in the blood serum.

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The effect of rutin on ovarian ischemia-reperfusion injury in a rat model

Cited by 42 publications

References 39 publications

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

Adalimumab mitigates ovarian ischemia–reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation

Effect of rutin on oxidative and proinflammatory damage induced by cisplatin in blood serum, ureter, bladder and urethra in rats

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