The Effect Of Roselle Extract (Hibiscus sabdariffa Linn.) On Blood Glucose Level And Total Antioxidant Level On Diabetic Rat Induced By Streptozotocin

Zakaria, Fransiska Rungkat; Prangdimurti, Endang; Damanik, Rizal

doi:10.9790/3013-0401008016

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…Oral administration of H. sabdariffa extract, as well as Glibenclamide significantly decreased blood glucose levels in a dose dependent manner. Our results were in line with several studies using H. sabdariffa extract to manage blood glucose level in rats [17,29,30]. To assess pancreas capacity to produce insulin after treatment with H. sabdariffa extract in alloxan-induced diabetic rats, OGTT was determined at the end of study.…”

Section: Discussionsupporting

confidence: 89%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

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Plants are known to possess relatively high efficacy in the treatment of several chronic diseases with fewer adverse effects. In the recent years, numerous medicinal plants have been reported to be effective in treating diabetes. Hence, the present study aims to evaluate the antidiabetic property of hydroalcoholic extract of Hibiscus sabdariffa (HS) calyces in diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg/kg, b.w), in male Wistar rats. Diabetic rats were administered daily oral doses of HS (100, 200 and 400 mg/kg body weight) and Glibenclamide (10 mg/kg) for 21 days. Then, blood glucose levels, oral glucose tolerance test and lipid profiles were determined. Treatment with HS resulted in a significant dose dependent reduction of blood glucose levels accompanied by a significant improvement in body weight. The extract also enhanced the glucose tolerance and significantly decreased cholesterol, triglycerides, and low-density lipoproteins levels while the high-density lipoproteins level significantly increased. From the results obtained, it can therefore be concluded that Hibiscus sabdariffa has an antidiabetic effect in alloxan-induced diabetic rats.

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Section: Discussionsupporting

confidence: 89%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

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“…Roselle has been proven to rich in nutrients like vitamins and polyphenol that might promote antioxidant properties (Jabeur et al, 2017;Riaz and Chopra, 2018). The roselle calyxes extract was found to promote health benefit as an anticancer and capable of reducing the chronic disease for instance hypertension, diabetes mellitus and cardiovascular disease (McKay et al, 2010;Akim et al, 2011;Mardiah et al, 2014;Formagio et al, 2015). Thus, it demonstrated that roselle juice could be an excellent carrier in developing functional beverages with GA as a prebiotic source.…”

Section: Introductionmentioning

confidence: 99%

Effect of gum arabic (Acacia senegal) addition on physicochemical properties and sensory acceptability of roselle juice

Azlan¹,

Hamzah²,

Majid³

2019

Food Res.

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Roselle has a brilliant red colour, high in vitamins and has a unique flavour that makes it suitable for juice production. Meanwhile, Gum Arabic (GA) is the edible dried exudate attained from stem and branch of Acacia senegal that contains high dietary fibre which can serve as prebiotic. Therefore, the application of GA into roselle juice might promote health benefits to consumers. GA is categorised as hydrocolloid and its application might affect important properties and acceptability towards the product. Hence, this study was conducted to investigate the effect of different concentrations of Gum Arabic (GA, Acacia senegal) addition (0%, 2%, 4% and 6%) on physicochemical properties and sensory acceptability of roselle juice. Increasing the GA concentration resulted in increased pH, total soluble solids, viscosity and turbidity values of roselle juice (p<0.05). However, the addition of GA had reduced the total anthocyanin content in roselle juice. For colour analysis, the addition of GA significantly (p<0.05) reduced the redness (a*) and yellowness (b*) properties. There was no significant difference in all attributes for sensory evaluation except for colour attribute. In conclusion, the addition of GA up to 6% into roselle juice caused an increase in pH, total soluble solids, viscosity and turbidity, but no effect to the sensory attributes.

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“…Aqueous extracts of red and white roselle were reported to reduce hyperglycemia through the inhibition of α-amylase and α-glucoside in an in vitro study as the enzymes responsible for carbohydrate hydrolysis, thus attenuating the occurrence of chronic diseases, mainly DM and CVDs [ 78 ]. Moreover, according to a study by Mardiah and colleagues [ 79 ], roselle aqueous extract given to type I diabetic rats at a dose of 288 mg/200 g body weight daily for 20 days reduced blood glucose due to the improvement of the number of β cells producing insulin in pancreatic cells. A study by Ajani et al [ 12 ] proved that roselle aqueous extract was able to reduce the percentage of glucose in the blood in type I diabetic models given 200 and 500 mg/kg of the extract for 28 days.…”

Section: Roselle In the Attenuation Of Cardiovascular Diseases Risk F...mentioning

confidence: 99%

Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors

Sapian,

Ibrahim Mze,

Jubaidi

et al. 2023

Pharmaceuticals

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Cardiovascular diseases (CVDs) represent a broad spectrum of diseases afflicting the heart and blood vessels and remain a major cause of death and disability worldwide. CVD progression is strongly associated with risk factors, including hypertension, hyperglycemia, dyslipidemia, oxidative stress, inflammation, fibrosis, and apoptosis. These risk factors lead to oxidative damage that results in various cardiovascular complications including endothelial dysfunctions, alterations in vascular integrity, the formation of atherosclerosis, as well as incorrigible cardiac remodeling. The use of conventional pharmacological therapy is one of the current preventive measures to control the development of CVDs. However, as undesirable side effects from drug use have become a recent issue, alternative treatment from natural products is being sought in medicinal plants and is gaining interest. Roselle (Hibiscus sabdariffa Linn.) has been reported to contain various bioactive compounds that exert anti-hyperlipidemia, anti-hyperglycemia, anti-hypertension, antioxidative, anti-inflammation, and anti-fibrosis effects. These properties of roselle, especially from its calyx, have relevance to its therapeutic and cardiovascular protection effects in humans. This review summarizes the findings of recent preclinical and clinical studies on roselle as a prophylactic and therapeutic agent in attenuating cardiovascular risk factors and associated mechanisms.

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The Effect Of Roselle Extract (Hibiscus sabdariffa Linn.) On Blood Glucose Level And Total Antioxidant Level On Diabetic Rat Induced By Streptozotocin

Abstract: : Roselle (Hibiscus sabdariffa Linn.)

Cited by 8 publications

References 29 publications

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Effect of gum arabic (Acacia senegal) addition on physicochemical properties and sensory acceptability of roselle juice

Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors

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