The effect of raisins on biomarkers of endothelial function and oxidant damage; an open-label and randomized controlled intervention

Kanellos, P.; Kaliora, Andriana C.; Protogerou, Athanase D.; Tentolouris, Nikolaοs; Perrea, Despina; Karathanos, Vaios Τ.

doi:10.1016/j.foodres.2017.09.061

Cited by 25 publications

(60 citation statements)

References 24 publications

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“…Some recent studies have suggested that biomarkers could be modified by environmental factors such as the type of food [22]. However, to the best of our knowledge, there is no study assessing the effect of environmental factors on VEGF and PDGF.…”

Section: Discussionmentioning

confidence: 99%

Intraplatelet Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor: New Biomarkers in Carcinoembryonic Antigen-Negative Colorectal Cancer?

Chater

Bauters

Beugnet

et al. 2018

Gastrointest Tumors

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Background/Aim: Colorectal cancer (CRC) is associated with high incidence and mortality rates. Carcinoembryonic antigen (CEA), a prognostic biomarker for recurrent CRC following curative resection, suffers from low sensitivity, especially in early-stage screening. Intraplatelet angiogenesis regulators (IPAR), such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), have been identified as important regulators of tumor growth in CRC. The aim of this study was to confirm the higher preoperative level of IPAR (VEGF and PDGF) in CRC patients compared to controls and to measure IPAR in CEA-negative CRC patients. Methods: The data and blood of 30 CRC patients and 30 presumably healthy controls were prospectively analyzed and compared. Results: We confirmed elevated preoperative intraplatelet VEGF and PDGF levels in CRC patients compared to controls. Importantly, IPAR were significantly elevated even in CEA-negative CRC patients. Conclusion: Elevated preoperative intraplatelet VEGF and PDGF levels in CRC patients suggest new possibilities for postoperative monitoring in CRC patients, especially when CEA is negative.

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Section: Discussionmentioning

confidence: 99%

Intraplatelet Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor: New Biomarkers in Carcinoembryonic Antigen-Negative Colorectal Cancer?

Chater

Bauters

Beugnet

et al. 2018

Gastrointest Tumors

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“…However, some other studies indicated that consuming 60 g of grape powder rich in polyphenols for 10 weeks had no significant effect on healthy participants with obesity (56) . Furthermore, taking 90 g of raisins (containing 138•5-221•5 mg polyphenols) per d for 4 weeks had no significant effect on CRP levels (57) . Other studies also found no significant effect of grape polyphenols on CRP levels (58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74) .…”

mentioning

confidence: 88%

“…We assessed quality of our included studies according to the Cochrane risk of bias tool (Table 2). Six of our included studies described random sequencing generation (57,62,63,69) but a lack of information was found in this regard in the other studies. Allocation concealment was performed in four studies (57,62,63,69) .…”

Section: Quality Assessment Of Studiesmentioning

confidence: 99%

“…A total of 668 participants were investigated in these studies: 469 individuals in the intervention and 429 people in the control groups. Regarding the place of studies, seven studies were conducted in Europe (51,57,61,62,64,71,72) , three in Australia (58,63,69) , five in America (56,(65)(66)(67)70) and two studies were carried out in Asia (68) and Africa (59) . All studies were randomised controlled trials with parallel or crossover design.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…All studies were conducted within 4-24 weeks and the doses of grape polyphenols were from 22•4 mg/d to 2000 mg/d. In addition, grape products containing polyphenols were administered in several forms of GSE (58,59,61,65) , grape powder (56,67,68,70) , red wine (51,63,64,69,72) , raisins (57) , grape juice (66) , grape extract (71) and grape polyphenols (62) .…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Sarkhosh-Khorasani

Hosseinzadeh

2020

Br J Nutr

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Although grape polyphenols can decrease chronic inflammations, their effect on C-reactive protein (CRP) levels is still controversial. So, this meta-analysis was conducted to investigate the effect of grape products containing polyphenols on CRP concentrations. In order to collect the relevant randomized controlled trials (RCTs), the data bases of PubMed, Scopus, Web of Science, and Google Scholar were searched up to March 30, 2020. The random-effects model, standardized mean difference, and 95% confidence interval were applied in data analysis. Meta-analysis was conducted over 17 eligible RCTs containing a total of 668 participants. The study registration number is CRD42018110169. Based on the results, grape products containing polyphenol decreased the CRP levels significantly (SMD = -0.229; 95% CI: -0.41, -0.05; P = 0.013). The sensitivity analysis was performed by removing each individual study and the results did not change. According to the subgroup analysis, higher doses of grape polyphenols (˃ 500 mg/d) and longer intervention periods (≥ 12 wk) had significant effects on CRP levels. Furthermore, grape polyphenols significantly reduced the CRP levels in patients with a clinical condition. In the same vein, grape seed extract and other grape products, such as grape extract, juice, and raisin, decreased the CRP levels significantly. According to the meta-regression results, the CRP level depends on the dose and duration of the grape polyphenols supplementation. Based on the findings, grape products containing polyphenols had a significant effect on CRP levels. Further well-designed and long-term clinical trials are highly recommended to achieve more comprehensive and accurate results.

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Effects of grape products on inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

Ghalishourani

Farzollahpour

Shirinbakhshmasoleh

et al. 2021

Phytotherapy Research

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This systematic review and meta‐analysis of randomized controlled trials (RCTs) were conducted to determine the effects of grapes and grape products on inflammation and oxidative stress among adults. PubMed, Scopus, ISI Web of Science, and Cochrane Library databases were searched up to July 2020 to identify RCTs investigating the effects of grape and grape products on inflammatory and oxidative stress markers. Weighted mean differences (WMD) were pooled using a random‐effects model. Of the 8,962 identified studies, 24 RCTs (27 arms) were included in the statistical analysis. Grape products significantly reduced serum C‐reactive protein (CRP) levels (WMD: −0.35 mg/L; 95% CI: −0.62, −0.09, p = .008), but they had no significant effect on serum tumor necrosis factor‐alpha (TNF‐α) (WMD = −1.08 pg/ml; 95% CI: −2.29, 0.11, p = .07), interleukin‐6 (IL‐6) (WMD = 0.13 pg/ml; 95% CI: −0.35, 0.60, p = .60), total antioxidant capacity (TAC) (WMD = 0.15; 95% CI: −0.35, 0.65, p = .54), or malondialdehyde (MDA) (WMD = 0.14; 95% CI: −0.64, 0.92, p = .72). The analysis indicated possible decreasing effects of grapes and grape products on CRP, but they might not be able to change IL‐6, TNF‐α, TAC, and MDA concentrations. Nonetheless, further studies are warranted before definitive conclusions may be reached.

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The effect of raisins on biomarkers of endothelial function and oxidant damage; an open-label and randomized controlled intervention

Cited by 25 publications

References 24 publications

Intraplatelet Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor: New Biomarkers in Carcinoembryonic Antigen-Negative Colorectal Cancer?

Intraplatelet Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor: New Biomarkers in Carcinoembryonic Antigen-Negative Colorectal Cancer?

The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Effects of grape products on inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

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