The effect of pyridazine compounds on the cardiovascular system

Asif, Mohammad; Singh, Anita; Siddiqui, Anees A.

doi:10.1007/s00044-011-9835-6

Cited by 51 publications

(39 citation statements)

References 72 publications

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“…Pyridazine derivatives (especially pyridazin-3-ones) have been considered as a magic moiety (wonder nucleus), 36 which posses almost all types of biological activities, 37 among others cardiovascular, 38 antimicrobial, 39 and analgesic. 40 …”

Section: Discussionmentioning

confidence: 99%

Reactivity of 1,2,3-triazole-substituted 1-azabutadienes (vinamidines)

Bátori¹,

Bokotey²,

Messmer³

2012

Arkivoc

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Section: Discussionmentioning

confidence: 99%

Reactivity of 1,2,3-triazole-substituted 1-azabutadienes (vinamidines)

Bátori¹,

Bokotey²,

Messmer³

2012

Arkivoc

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“…Moreover, there has been growing interest in the synthesis of biologically active pyridazine derivatives in the last decade . Furthermore, many organic compounds containing pyrimidine nuclei are highly efficient towards various microorganisms such as anti‐inflammatory and antimicrobial activities , where a number of pyridazine derivatives have interesting pharmacological and anticancer activities . On the other hand, many fats and oils are used to produce customized products, which are useful for synthesis of environmentally friendly and new compounds .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Surface, and Antimicrobial Activity of Hydrophobically Thiadiazole, Pyridazine, and Pyrimidine Systems Based on Surface Active Agents

Althagafi

El‐Sayed

2018

Journal of Heterocyclic Chem

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A series of hydrophobically thiadiazole, pyridazine, and pyrimidine were synthesized with surface and biological activities from cheap, available, and safe raw materials such as fatty acids. Thus, diazotizations of thiadiazole derivative 2 and malononitrile resulted a hydrazone derivative 3, which was used to construct various biologically active compounds with low toxicity, good solubility and biodegradation, surface properties with biological activity. The results revealed that these substances have the ability to reduce the surface tension, reduce the wetting time, varying degrees of foam and emulsifying stability, which makes use in the different industries. As well as their biodegradability, which confirms that these compounds are environmentally friendly to humans and the environment. Furthermore, the effect of these compounds against certain microorganisms has been studied and shown to be highly effective against the activity of these organisms.

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“…Pyridazine derivatives and its condensed systems phthalazines, are well known scaffolds in medicinal chemistry [3,4], possessing a large variety of biological activities such as antihypertensive [5], diuretic [6], antiplatelet [7], cardiotonic [8], anticancer [9], anti-HIV [10], anti-inflammatory [11], antimicrobial (antibacterial, antifungal, anti-tuberculosis) [12,13], so on. Synthesis of functionalized acetophenone derivatives is an important goal for organic synthesis, these derivatives and particulary dihydroxyacetophenone, exhibiting interesting biological properties, these including antimicrobial [14] and anticancer activities [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and In vitro Analysis of Novel Dihydroxyacetophenone Derivatives with Antimicrobial and Antitumor Activities

Zbancioc¹,

Tuchiluş²,

Rotinberg³

et al. 2014

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Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave (MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.

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The effect of pyridazine compounds on the cardiovascular system

Cited by 51 publications

References 72 publications

Reactivity of 1,2,3-triazole-substituted 1-azabutadienes (vinamidines)

Reactivity of 1,2,3-triazole-substituted 1-azabutadienes (vinamidines)

Synthesis, Surface, and Antimicrobial Activity of Hydrophobically Thiadiazole, Pyridazine, and Pyrimidine Systems Based on Surface Active Agents

Synthesis and In vitro Analysis of Novel Dihydroxyacetophenone Derivatives with Antimicrobial and Antitumor Activities

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