Synthesis, Surface, and Antimicrobial Activity of Hydrophobically Thiadiazole, Pyridazine, and Pyrimidine Systems Based on Surface Active Agents

Abstract

A series of hydrophobically thiadiazole, pyridazine, and pyrimidine were synthesized with surface and biological activities from cheap, available, and safe raw materials such as fatty acids. Thus, diazotizations of thiadiazole derivative 2 and malononitrile resulted a hydrazone derivative 3, which was used to construct various biologically active compounds with low toxicity, good solubility and biodegradation, surface properties with biological activity. The results revealed that these substances have the ability to reduce the surface tension, reduce the wetting time, varying degrees of foam and emulsifying stability, which makes use in the different industries. As well as their biodegradability, which confirms that these compounds are environmentally friendly to humans and the environment. Furthermore, the effect of these compounds against certain microorganisms has been studied and shown to be highly effective against the activity of these organisms.

Serendipitous Formation of 2H-Pyrazolo[3,4-d]pyridazin-7(6H)-ones from 3-Arylsydnones

“…Pyrazole and their derivatives possess a wide range of bioactivities. − Pyridazine and their analogues were thought worthwhile to study because they are available as a number of marketed drugs such as Hydralazine, Minaprine, and Cefozopran . It has also been reported that pyridazine derivatives display anticancer, anti-HIV, antihypertensive, antimicrobial, and antifungal activities. − …”