Synthesis of Pyrimidine and Pyran Derivatives with the Related Systems and the Study of Their Behavior in the Liquid Solutions

Abstract

This study aims to synthesis of condensed and non‐condensed heterocyclic rings with long fatty chains as surface active biological compounds. 2‐Cyano‐3‐(dimethylamino)‐N‐octadecylacrylamide (5) was used to synthesize pyrimidine, pyran, and other condensed products by interacting with appropriate chemical reagents. These compounds were transferred to nonionic surface‐active agents by condensation with propylene oxide. The surface and biological properties showed that these compounds have a high solubility that helps them in easy absorption and adsorption with other compounds. In addition, they have a high ability to decrease the surface tension of the liquids, good wetting, and emulsification power, which can be used at different temperatures without losing their surface or biological properties and enable them for use in industrial and pharmaceutical purposes easily.

Application of 2-Aminopyridines in the Synthesis of Five- and Six-Membered Azaheterocycles

“…类似地, 含有多官能团的 α,β-不饱和酰胺化合物 [90] 也能与 2-氨基吡啶发生成环反应. 例如, 董德文课题 组 [91] 基于 2-氨基吡啶构建吡啶并[1,2-a]嘧啶的多组分反 应, 也是化学工作者们的研究热点 [92][93] , 其中一个底物 可以是酯类化合物 [94] .…”

An efficient multicomponent synthesis of 1H-pyrano[2,3-d]pyrimidine-2,4(3H,5H)-dione derivatives and evaluation of their α-amylase and α-glucosidase inhibitory activity

“…Heterocyclic compounds containing one or more functionalized units are of great significance in daily life because of their pronounced medicinal value. 1 Molecular hybridization is a new approach in rational drug designing and the development of novel molecules or prototypes in which chemical modifications made to existing pharmacophores leads to the new hybrid compounds. These can have reduced toxicity, improved physicochemical properties and biological activities, and most importantly, enhanced specificity towards the particular receptor.…”